Formulation of Lipid-Based Nanoparticles for Simultaneous Delivery of Lapatinib and Anti-Survivin siRNA for HER2+ Breast Cancer Treatment [PDF]
Pharmaceuticals, 2022 In this work, lipid-based nanoparticles (LBNP) were designed to combine tyrosine kinase inhibitor (TKI) Lapatinib (LAPA) with siRNA directed against apoptosis inhibitor protein Survivin (siSurvivin) in an injectable form.
Sahar Eljack +4 more
doaj +2 more sources
Combination of Nanovectorized siRNA Directed against Survivin with Doxorubicin for Efficient Anti-Cancer Activity in HER2+ Breast Cancer Cells [PDF]
Pharmaceutics, 2022 According to Globocan 2020, breast cancer is considered one of the most common cancers affecting women and is one of the leading causes of death in over 100 countries.
Sahar Eljack +7 more
doaj +2 more sources
In vitro synergistic activity of cisplatin and EGFR-targeted nanomedicine of anti-Bcl-xL siRNA in a non-small lung cancer cell line model [PDF]
International Journal of Pharmaceutics: X, 2022 Apoptosis is an important process that directly affects the response of cancer cells to anticancer drugs. Among different factors involved in this process, the BcL-xL protein plays a critical role in inhibiting apoptosis induced by chemotherapy agents ...
Phuoc Vinh Nguyen +6 more
doaj +2 more sources
Formation of miRNA Nanoprobes—Conjugation Approaches Leading to the Functionalization [PDF]
Molecules, 2022 Recently, microRNAs (miRNA) captured the interest as novel diagnostic and prognostic biomarkers, with their potential for early indication of numerous pathologies.
Iveta Vilímová +2 more
doaj +2 more sources
Estimating the Analytical Performance of Raman Spectroscopy for Quantification of Active Ingredients in Human Stratum Corneum [PDF]
Molecules, 2022 Confocal Raman microscopy (CRM) has become a versatile technique that can be applied routinely to monitor skin penetration of active molecules. In the present study, CRM coupled to multivariate analysis (namely PLSR—partial least squares regression) is ...
Hichem Kichou +9 more
doaj +2 more sources
Label-Free Quantification of Nanoencapsulated Piperonyl Esters in Cosmetic Hydrogels Using Raman Spectroscopy [PDF]
Pharmaceutics, 2023 Raman spectroscopy is a well-established technique for the molecular characterisation of samples and does not require extensive pre-analytical processing for complex cosmetic products.
Suha Elderderi +7 more
doaj +2 more sources
Confocal Raman Spectroscopic Imaging for Evaluation of Distribution of Nano-Formulated Hydrophobic Active Cosmetic Ingredients in Hydrophilic Films [PDF]
Molecules, 2021 Film-forming systems are highly relevant to the topical administration of active ingredients (AI) to the body. Enhanced contact with the skin can increase the efficacy of delivery and penetration during prolonged exposure.
Louise Van Gheluwe +10 more
doaj +2 more sources
Structural and Functional Analysis of Excised Skins and Human Reconstructed Epidermis with Confocal Raman Spectroscopy and in Microfluidic Diffusion Chambers [PDF]
Pharmaceutics, 2022 Several ex vivo and in vitro skin models are available in the toolbox of dermatological and cosmetic research. Some of them are widely used in drug penetration testing.
Dorottya Kocsis +6 more
doaj +2 more sources
Novel aspects of Raman spectroscopy in skin research. [PDF]
Exp Dermatol, 2022 Abstract The analytical technology of Raman spectroscopy has an almost 100‐year history. During this period, many modifications and developments happened in the method like discovery of laser, improvements in optical elements and sensitivity of spectrometer and also more advanced light detection systems. Many types of the innovative techniques appeared
Lunter D +5 more
europepmc +2 more sources
In Situ Water Quantification in Natural Deep Eutectic Solvents Using Portable Raman Spectroscopy [PDF]
Molecules, 2021 Raman spectroscopy is a label-free, non-destructive, non-invasive analytical tool that provides insight into the molecular composition of samples with minimum or no sample preparation.
Suha Elderderi +9 more
doaj +2 more sources