Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal [PDF]
International Journal of Pharmaceutics: X, 2022 Chemoresistance and hence the consequent treatment failure is considerably challenging in clinical cancer therapeutics. The understanding of the genetic variations in chemoresistance acquisition encouraged the use of gene modulatory approaches to restore
Sahar Eljack +4 more
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Design and Validation of Nanofibers Made of Self-Assembled Peptides to Become Multifunctional Stimuli-Sensitive Nanovectors of Anticancer Drug Doxorubicin [PDF]
Pharmaceutics, 2022 Self-assembled peptides possess remarkable potential as targeted drug delivery systems and key applications dwell anti-cancer therapy. Peptides can self-assemble into nanostructures of diverse sizes and shapes in response to changing environmental ...
Valentina Del Genio +8 more
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Comparison of Vibrational Spectroscopic Techniques for Quantification of Water in Natural Deep Eutectic Solvents [PDF]
Molecules, 2022 Vibrational spectroscopic techniques, i.e., attenuated total reflectance infrared (ATR-IR), near infrared spectroscopy (NIRS) and Raman spectroscopy (RS), coupled with Partial Least Squares Regression (PLSR), were evaluated as cost-effective label-free ...
Suha Elderderi +9 more
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Peptides to Overcome the Limitations of Current Anticancer and Antimicrobial Nanotherapies [PDF]
Pharmaceutics, 2022 Biomedical research devotes a huge effort to the development of efficient non-viral nanovectors (NV) to improve the effectiveness of standard therapies.
Valentina Del Genio +5 more
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Freezing Weakens the Barrier Function of Reconstructed Human Epidermis as Evidenced by Raman Spectroscopy and Percutaneous Permeation [PDF]
Pharmaceutics, 2020 The development and characterization of reconstructed human epidermis (RHE) is an active area of R&D. RHE can replace animal tissues in pharmaceutical, toxicological and cosmetic sciences, yielding scientific and ethical advantages.
Yuri Dancik +6 more
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Biomarkers in the era of targeted therapy in giant cell arteritis and polymyalgia rheumatica: is it possible to replace acute-phase reactants? [PDF]
Frontiers in Immunology, 2023 Research into giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) has become more important in the last few decades. Physicians are facing several challenges in managing the diagnosis, treatment, and relapses of GCA and PMR patients.
Guillermo Carvajal Alegria +3 more
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Nanovectorized Microalgal Extracts to Fight Candida albicans and Cutibacterium acnes Biofilms: Impact of Dual-Species Conditions [PDF]
Antibiotics, 2020 Biofilm-related infections are a matter of concern especially because of the poor susceptibility of microorganisms to conventional antimicrobial agents. Innovative approaches are needed.
Virginie Lemoine +7 more
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In vitro Label Free Raman Microspectroscopic Analysis to Monitor the Uptake, Fate and Impacts of Nanoparticle Based Materials [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 The continued emergence of nanoscale materials for nanoparticle-based therapy, sensing and imaging, as well as their more general adoption in a broad range of industrial applications, has placed increasing demands on the ability to assess their ...
Hugh J. Byrne +4 more
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Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes [PDF]
Journal of Nanobiotechnology, 2018 Background Recent advances in nanomedicine have shown the great interest of active targeting associated to nanoparticles. Single chain variable fragments (scFv) of disease-specific antibodies are very promising targeting entities because they are small ...
Christophe Alric +11 more
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Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS Regression Models [PDF]
PharmaceuticsBackground: Chinese hamster ovary (CHO) cell metabolism is complex, influenced by nutrients like glucose and glutamine and metabolites such as lactate.
Morandise Rubini +11 more
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