Results 41 to 50 of about 1,101,713 (324)

Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

open access: yesNature Communications, 2019
There is a need to further improve the efficacy of biodegradable wafers used in surgically treated brain tumors. Here, the authors report a flexible, biodegradable wireless device capable of adhesion to surgical site for optimal drug delivery upon mild ...
Jongha Lee   +20 more
doaj   +1 more source

Curved neuromorphic image sensor array using a MoS2-organic heterostructure inspired by the human visual recognition system

open access: yesNature Communications, 2020
Designing efficient bio-inspired visual recognition system remains a challenge. Here the authors present a curved neuromorphic image sensor array based on a heterostructure of MoS2 and pV3D3 integrated with a plano-convex lens for efficient image ...
Changsoon Choi   +13 more
doaj   +1 more source

Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment

open access: yesNature Communications, 2022
Digestive surgical leaks manifesting days after a successful surgery can lead to severe complications and affect healthcare worldwide. Here, the authors address the problem holistically with a hydrogel patch capable of sealing tissues, while detecting ...
Alexandre H. C. Anthis   +11 more
doaj   +1 more source

Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform [PDF]

open access: yes, 2018
Stimuli-responsive nanoparticles hold great promise for drug delivery to improve the safety and efficacy of cancer therapy. One of the most investigated stimuli-responsive strategies is to induce drug release by heating with laser, ultrasound, or ...
Agarwal, Pranay   +7 more
core   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

Single Source Precursor-based Solvothermal Synthesis of Heteroatom-doped Graphene and Its Energy Storage and Conversion Applications

open access: yesScientific Reports, 2014
Solvothermal processes are considered efficient approaches for the gram-scale production of graphene. Further modification of graphene by chemical doping is an important approach to tailor its properties.
Bo Quan   +6 more
doaj   +1 more source

Machine Learning Classification Model to Label Sources Derived from Factor Analysis Receptor Models for Source Apportionment

open access: yesAerosol and Air Quality Research, 2023
Factor analysis (FA) receptor models are widely used for source apportionment (SA) due to their ability to extract the source contribution and profile from the data.
Vikas Kumar   +3 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Effect of crosslinker length on the elastic and compression modulus of poly(acrylamide) nanocomposite hydrogels [PDF]

open access: yes, 2017
Polymer hydrogelshave shown to exhibit improved properties upon the addition of nanoparticles; however, the mechanical underpinnings behind these enhancements have not been fully elucidated.
Asuri, Prashanth   +2 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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