Results 141 to 150 of about 8,969 (258)

Quality by Design-Based Scale-Up and Industrial Development of Turmeric Extract-Loaded Nanostructured Lipid Carriers. [PDF]

Pharmaceutics
Jandang W, Saokham P, Prathumwon C, Okonogi S, Ampasavate C.   +4 more
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Antibacterial Activity and Safety of Oregano Oil-Lauric Acid Cationic Nanostructured Lipid Carriers in Nile Tilapia (<i>Oreochromis niloticus</i>). [PDF]

Animals (Basel)
Kumanbut R, Kamble MT, Sirimanapong W, Kitiyodom S, Yostawonkul J, Thompson KD, Pirarat N.   +6 more
europepmc   +1 more source

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, EarlyView.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

Nanoemulsions and Nanostructured Lipid Carriers Containing Polyunsaturated Fatty Acids and Peptides from Mullet (<i>Mugil liza</i>). [PDF]

ACS Omega
Quadros C, Rodrigues KP, Arrieira NM, Cabrera D, Salas-Mellado M, Michelon M.   +5 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Enhanced encapsulation and membrane retention of <i>Teleogryllus mitratus</i> protein via hydrophobic ion-pairing in nanostructured lipid carriers. [PDF]

Int J Pharm X
Inthorn J, Somwongin S, Juntrapirom S, Kanjanakawinkul W, Heinz A, Müllertz A, Rades T, Chaiyana W.   +7 more
europepmc   +1 more source

Nanostructure Lipid Carriers: A Promising Approach for Hyperlipidemia Treatment

Hyperlipidemia, characterized by elevated levels of blood lipids such as triglycerides and cholesterol, remains a major contributor to cardiovascular diseases including atherosclerosis and coronary artery disease. Although statins are the first-line therapy for managing hyperlipidemia due to their ability to inhibit HMG-CoA reductase, they are ...
openaire   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source