Results 61 to 70 of about 4,959 (213)

Formulation and Evaluation of Nanosuspension Containing Poorly Water Soluble Ciclopirox Olamine as topical antifungal agent [PDF]

, 2023
Nanosuspension is a Novel concept, that administered topically can increases the residence time of drugs in stratum corneum and epidermis, while decreasing the drug\u27s absorption related side effect throughout the body.
Ritu Kumari, Nadeem Farooqui, Darshan Jamindar, Pritesh Paliwal, Nimita Manocha
core   +1 more source

Formulation and validation of Candesartan cilexetil-loaded nanosuspension to enhance solubility [PDF]

Pharmacia
The following research aimed to enhance solubility by loading candesartan cilexetil into nanosuspension. Candesartan cilexetil-loaded nanosuspension was prepared with the aid of Design-Expert® software.
Sarmad Al-Edresi, Karrar Albo Hamrah, Abulfadhel Al-Shaibani   +2 more
doaj   +3 more sources

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Ziprasidone Hydrochloride Nanosuspension for Bioavailability Enhancement: Design, Development and Evaluation [PDF]

E3S Web of Conferences
Ziprasidone hydrochloride belongs to BCS Class II since it possesses high membrane permeability along with low solubility properties. Research shows that the full available amount of a 20 mg dose reaches the body system at a rate of 60%.A research study ...
Paun Jalpa S., Tank Hemraj M., Savalia Vaibhavi B., Krishna Chaitanya J.   +3 more
doaj   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

NANOSUSPENSIONS – A REVIEW

, 2020
The interest in the preparation and application of nanometer-sized materials is increasing due to their tremendous potential as a drug delivery system with wide range of applications. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to ...
openaire   +2 more sources

A Design of Experiment (DoE) based approach for development and optimization of nanosuspensions of telmisartan, a BCS class II antihypertensive drug

Future Journal of Pharmaceutical Sciences, 2020
Background The present study was aimed to enhance the solubility and dissolution of BCS class II drug, telmisartan (TEM), by nanoformulation approach. Several attempts were made to develop a nanosuspension by bottom-up and top-down techniques.
E. Bhargav, G. Chaithanya Barghav, Y. Padmanabha Reddy, Chintamaneni Pavan kumar, P. Ramalingam, C. Haranath   +5 more
doaj   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Formulation and Evaluation of Teneligliptin Nanosuspension

, 2021
In this present study, the drug Teneligliptin is selected based on literature review for the management of Type-2 Diabetes mellitus. ❖ The drug-excipient compatibility study results showed that there is no chemical change occur between the drug and the ...
Sreekala, M G
core  

Injectable nanosuspension of docetaxel-loaded biodegradable periodic mesoporous Organosilica: A stable formulation with enhanced anticancer efficacy

Journal of Science: Advanced Materials and Devices
Current intravenous docetaxel (DTX) formulations often contain excipients like polysorbate 80 and high-dose ethanol, which are associated with severe adverse effects and compound DTX's inherent systemic toxicity. This study addresses these limitations by
Van-Ha Nguyen, Huiping Huang, Dang-Khoa Nguyen, Minh-Quan Le, Linh Ho Thuy Nguyen, Thang Bach Phan, Minh-Tri Le, Tan Le Hoang Doan   +7 more
doaj   +1 more source