Results 121 to 130 of about 9,159 (296)

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Using Cu‐Based Metal–Organic Framework as a Comprehensive and Powerful Antioxidant Nanozyme for Efficient Osteoarthritis Treatment

Advanced Science
Developing nanozymes with effective reactive oxygen species (ROS) scavenging ability is a promising approach for osteoarthritis (OA) treatment. Nonetheless, numerous nanozymes lie in their relatively low antioxidant activity.
Bo Yu, Wei Sun, Juntao Lin, Chaoyu Fan, Chengxinqiao Wang, Zhisen Zhang, Yupeng Wang, Yonghua Tang, Youhui Lin, Dongfang Zhou   +9 more
doaj   +1 more source

The Oxidase Mimicking Activity of MnOx NPs/Co3O4 NPs Hybrid Nanozyme for Glucose Oxidation

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Herein, the hybrid nanozyme MnOx NPs/Co3O4 NPs on indium tin oxide coated glass substrate (ITO) was manufactured by imparting the porous morphology with its distinct merits: its surface valence states, oxygen vacancies, large surface area, and abundant ...
Bekir Çakıroğlu
doaj   +1 more source

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Biocompatible copper single-atom site nanozyme for parallel tumor therapy

Nano Research
Reasonable design and construction of artificial enzymes with excellent catalytic activity, good stability and superior biocompatibility is essential for tumor therapy.
Haining Zhou, Hui Peng, Yugui Lian, Ting Sun, Chang Su, Zhiyuan Wang   +5 more
doaj   +1 more source

Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

Advanced Science, EarlyView.
The SPG‐MpECis electrochemical POCT platform developed in this study enables direct detection of biomarkers in complex biological samples such as serum and fingerstick blood, demonstrating high concordance with results from clinical reference methods and holding broad potential for at‐home testing applications.
Menghan Li, Kai Su, Ruiwei Hu, Ke Gao, Yuanjie Liu, Lu Zhang, Ningke Fan, Yirong Chen, Wei Cheng, Shijia Ding, Haiping Wu   +10 more
wiley   +1 more source

A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy

Advanced Science
Despite considerable advancements in the treatment of colorectal cancer (CRC), the overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis.
Shuohui Dong, Haolin Cao, Ye Yuan, Shuo Liang, Zhendong Fu, Wei Shi, Qian Xu, Xiang Zhao, Jingnan Shi, Xiaoxiao Guo, Kaili Guo, Sanyuan Hu, Guangyong Zhang, Lizeng Gao, Lei Chen   +14 more
doaj   +1 more source

The synergistic antibacterial effects of photothermal and enzymatic catalysis mediated by Pd/ZIF-8 nanozyme

Guangxi Yike Daxue xuebao
Objective To explore the synergistic antibacterial performance of photothermal and enzymatic catalysis mediated by Pd/ZIF-8 nanozyme, and assess its potential for biomedical applications.
Miao MO, Zhangrui HUANG, Xin ZHAO, Jingping ZHONG   +3 more
doaj   +1 more source

Synergistic Combination of an Intelligent Nanozyme and Radiotherapy for Treating Renal Cancer

Lei Lei, Ke Wang Henan Provincial Chest Hospital, Zhengzhou, 450008, Henan, People’s Republic of ChinaCorrespondence: Ke Wang, Email 13837178129@163.comBackground: Preserving nephrons while avoiding tumor recurrence during the treatment of renal cell ...
Lei L, Wang K
core  

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source