Results 121 to 130 of about 9,718 (271)

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy

Advanced Science
Despite considerable advancements in the treatment of colorectal cancer (CRC), the overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis.
Shuohui Dong, Haolin Cao, Ye Yuan, Shuo Liang, Zhendong Fu, Wei Shi, Qian Xu, Xiang Zhao, Jingnan Shi, Xiaoxiao Guo, Kaili Guo, Sanyuan Hu, Guangyong Zhang, Lizeng Gao, Lei Chen   +14 more
doaj   +1 more source

The synergistic antibacterial effects of photothermal and enzymatic catalysis mediated by Pd/ZIF-8 nanozyme

Guangxi Yike Daxue xuebao
Objective To explore the synergistic antibacterial performance of photothermal and enzymatic catalysis mediated by Pd/ZIF-8 nanozyme, and assess its potential for biomedical applications.
Miao MO, Zhangrui HUANG, Xin ZHAO, Jingping ZHONG   +3 more
doaj   +1 more source

Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy

Advanced Science, EarlyView.
Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu, Liang Li, Siyu Pan, Yuehan Jian, Yuhan Chen, Wenjie Yang, Guang Song, Xueyang Fang, Ping'an Ma, Lijun Jiang   +9 more
wiley   +1 more source

Catalytic imaging-guided cancer therapy using non-coordinated and coordinated nanozymes [PDF]

Nanozymes with and without coordinated structures, in addition to performing enzyme-mimic activities through converting O2[rad]– to H2O2 or H2O2 into O2 and [rad]OH, are of interest in the development of diagnostic imaging and image-guided therapy ...
Cai, Yu, Falahati, Mojtaba, Haghighat, Setareh, Sharifi, Majid, ten Hagen, Timo L.M., Vahdani, Yasaman   +5 more
core   +1 more source

Nanozymes for Treating Ocular Diseases

Advanced Healthcare Materials
AbstractNanozymes, characterized by their nanoscale size and enzyme‐like catalytic activities, exhibit diverse therapeutic potentials, including anti‐oxidative, anti‐inflammatory, anti‐microbial, and anti‐angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery.
Ka‐Ying Wong, Man‐Sau Wong, Juewen Liu   +2 more
openaire   +3 more sources

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment

Military Medical Research
The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances.
Si-Jie Zhang, Ran Xu, Shao-Bin He, Rong Sun, Guan-Nan Wang, Shu-Yi Wei, Xi-Yun Yan, Ke-Long Fan   +7 more
doaj   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source