Results 81 to 90 of about 9,159 (296)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Nanozyme-Based Biofuel Cell Ingeniously Coupled with Luminol Chemiluminescence System through In Situ Co-Reactant Generation for Dual-Signal Biosensing

Classical luminol-based chemiluminescence (CL) is the process of emitting light enhanced by the addition of coreactant hydrogen peroxide (H2O2). To address the instability issue of H2O2 decomposition, herein, we proposed a nanozyme-based biofuel cell ...
Feng Li (30515), Cui Wang (141700), Yuqing Wang (110531), Panpan Gai (3697063), Junhua Liu (1570747)   +4 more
core   +1 more source

EDTAFe2+ Complex-Functionalized Fe3O4 Nanozyme as Tyrosine Hydroxylase Mimics for the Production of lDOPA

, 2022
l-3,4-Dihydroxyphenylalanine (l-DOPA) is widely used in the treatment of Parkinson’s disease. Fe3O4 magnetic nanoparticles decorated with ethylenediaminetetraacetic acid (EDTA)–Fe2+ complexes were developed as nanozymes for the biomimetic synthesis of l ...
Ling Zhang, Weikang Tang (6836333), Mengqi Han (636970), Chan Chen, Qi Shang (3044835), Qinfei Chen (12095662), Qi Shang, Wenbin Liu (174604), Mengqi Han, Qinfei Chen, Weikang Tang, Wenbin Liu, Ling Zhang (18071), Chan Chen (328692)   +13 more
core   +1 more source

Coordination‐Tuned Iridium Single‐Atom Nanozymes Boost Multienzyme Activity for Colorimetric Sensing

Advanced Science, EarlyView.
Breaking the coordination symmetry of Ir single‐atom sites through asymmetric Ir–N3S1 engineering tailors interfacial electron transfer, oxygen activation, and multienzyme‐like catalytic pathways. Operando spectroscopy and theoretical modeling uncover the atomic‐level origin of activity enhancement, providing a strategy for designing multifunctional ...
Tao Li, Xinyu Zhang, Jiashan Xia, Mengyu Wu, Cong Liu, Yapei Sun, Wanjiang Zhao, Min Qian, Wei Wang, Weixia Duan, Shangcheng Xu   +10 more
wiley   +1 more source

pH‐Activatable Pre‐Nanozyme Mediated H2S Delivery for Endo‐Exogenous Regulation of Oxidative Stress in Acute Kidney Injury

Advanced Science
Oxidative stress induced by excess reactive oxygen species (ROS) is a primary pathogenic cause of acute kidney injury (AKI). Development of an effective antioxidation system to mitigate oxidative stress for alleviating AKI remains to be investigated ...
Wei Jiang, Xinyue Hou, Yuanbo Qi, Zhigang Wang, Ying Liu, Xuejiao J. Gao, Tingting Wu, Jiancheng Guo, Kelong Fan, Wenjun Shang   +9 more
doaj   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations

Signal Transduction and Targeted Therapy
Transferrin receptor 1 (TfR1), a widely expressed type II transmembrane glycoprotein located on the plasma membrane, is well known for its established role in cellular iron uptake.
Yaxin Hou, Guoheng Tang, Qizhi Wang, Meng Zhou, Ran Xu, Xuehui Chen, Guizhi Shi, Zhuoran Wang, Xiyun Yan, Jie Zhuang, Kelong Fan   +10 more
doaj   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Emerging versatile nanozymes for the therapeutic and diagnostic applications of diseases

Journal of Translational Medicine
Nanozyme has become a new rising star in the medical field because of its high stability, strong catalysis, ease of modification and manufacturing compared with natural enzyme.
Xinhao Jin, Fangxiao Guo, Mingyang Wu, Chengxi Xu, Yiming Li, Guanhui Chen   +5 more
doaj   +1 more source