Results 61 to 70 of about 9,159 (296)

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

SOD1 nanozyme salvages ischemic brain by locally protecting cerebral vasculature [PDF]

, 2015
Copper/zinc superoxide dismutase (CuZnSOD; SOD1) is widely considered as a potential therapeutic candidate for pathologies involving oxidative stress, but its application has been greatly hindered by delivery issues.
Brynskikh, Anna M., Jiang, Yuhang, S-Manickam, Devika, Kabanov, Alexander V.   +3 more
core   +1 more source

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy

Advanced Science
Mild‐temperature photothermal therapy (mPTT) is attractive for cancer treatment due to its safety and precision but is limited by heat shock protein 70 (HSP70)‐mediated thermotolerance, which allows tumor cells to survive sublethal heating.
Shuyu Wang, Shenghui Wang, Mengyuan Cao, Lulu Wang, Wei Jiang, Xiyun Yan, Ying Liu, Bing Jiang   +7 more
doaj   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source

Stable peptide-assembled nanozyme mimicking dual antifungal actions

Nature Communications
Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic candidates against antimicrobial resistance but suffer from low efficiency and poor stability. Here, we develop peptide nanozymes which mimic the mode of action of AMPs
Ye Yuan, Lei Chen, Kexu Song, Miaomiao Cheng, Ling Fang, Lingfei Kong, Lanlan Yu, Ruonan Wang, Zhendong Fu, Minmin Sun, Qian Wang, Chengjun Cui, Haojue Wang, Jiuyang He, Xiaonan Wang, Yuan Liu, Bing Jiang, Jing Jiang, Chenxuan Wang, Xiyun Yan, Xinzheng Zhang, Lizeng Gao   +21 more
doaj   +1 more source

Nanozyme-Based Colorimetric Sensors for the Detection of Urinary Biomarkers of Early Onset Diabetes and Renal Deterioration

Nanozymes are nanomaterials that possess intrinsic enzyme-mimicking catalytic activity and have the potential to be used in sensing, disease diagnosis, drug delivery, and environmental remediation applications.
Sanjana Naveen Prasad (18047617)
core   +1 more source

Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury

, 2019
Metal nanozyme has attracted wide interest for biomedicine, and a highly catalytic material in the physiological environment is highly desired. However, catalytic selectivity of nanozyme is still highly challenging, limiting its wide application.
Wei Long (411482), Jingya Wang (3409949), Xiaoyu Mu (552544), Lufei Ouyang (6341243), Yaqi Jing (3738679), Haile Liu (6341246), Yuanming Sun (357172), Haitao Dai (1529791), Junying Wang (509009), Xiao-Dong Zhang (281397), Fujuan Xu (3738682), Yonghui Li (234707), Qiang Liu (166143), Changlong Liu (1865293)   +13 more
core   +1 more source

Piezoelectric Effect Modulates Nanozyme Activity: Underlying Mechanism and Practical Application

, 2023
Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme activity by generating positive and negative charges on piezoelectric materials\u27 surfaces.
Yu, Xin, Wang, Aizhu,, Zhang, Jian,, Liu, Jing, Han, Xun,, Aizhu Wang, Jing Liu, Zhang, Jian, Zhu, Zhiling,, Ding, Long Hua,, Wang, Aizhu, Ding, Long Hua, Han, Xun, Xun Han, Zhu, Zhiling, Liu, Jing,, Longwei Wang, Jian Zhang, Zhiling Zhu, Wang, Longwei,, Xin Yu, Wang, Longwei, Longhua Ding, Yu, Xin,   +23 more
core   +1 more source