Results 51 to 60 of about 9,159 (296)

Engineering Metal‐Pocket Cooperativity in Single‐Atom COF Nanozymes for Selective Cascade Catalysis

Advanced Materials, EarlyView.
A multilevel programming strategy is developed to engineer single‐atom COF nanozymes with tunable metal centers and chiral pockets inspired by heme–pocket cooperativity. This approach enables controlled metal–pocket interplay for asymmetric cascade catalysis, delivering high activity, selectivity, and recyclability in an asymmetric oxidation–aldol ...
Ziping Li, Qijun Sun, Yawen Hao, Haotian Wen, Shery Chang, Fengwang Li, Jiangtao Xu, Kang Liang   +7 more
wiley   +1 more source

Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation [PDF]

, 2015
Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential. This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed
Manickam, Devika S., Shekhter, Anatoly B., Binevski, Petr V., Beznos, Olga V., Chesnokova, Natalia B., Guller, Anna E., Kost, Olga A., Klyachko, Natalia L., Davydova, Nina G., Kabanov, Alexander V., Nikolskaya, Irina I.   +10 more
core   +3 more sources

Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy

Nature Communications
Lysosome-targeting chimeras (LYTACs) hold therapeutic potential by degrading pathogenesis-associated proteins. However, current LYTAC systems often require considerable effort for case-by-case construction and are devoid of a convenient and efficient ...
Shuai Zhang, Yiliang Jin, Yaxin Hou, Guoheng Tang, Zhuoran Wang, Xuehui Chen, Xiyun Yan, Kelong Fan   +7 more
doaj   +1 more source

Protein‐Nanocaged Selenium Induces t(8;21) Leukemia Cell Differentiation via Epigenetic Regulation

Advanced Science, 2023
The success of arsenic in degrading PML‐RARα oncoprotein illustrates the great anti‐leukemia value of inorganics. Inspired by this, the therapeutic effect of inorganic selenium on t(8; 21) leukemia is studied, which has shown promising anti‐cancer ...
Long Fang, Ruofei Zhang, Lin Shi, Jiaying Xie, Long Ma, Yili Yang, Xiyun Yan, Kelong Fan   +7 more
doaj   +1 more source

Tri-element nanozyme PtCuSe as an ingenious cascade catalytic machine for the amelioration of Parkinson’s disease-like symptoms

Frontiers in Bioengineering and Biotechnology, 2023
Parkinson’s disease (PD), as the second most common neurodegenerative disease after Alzheimer’s, has become intractable with the increasing aging global population.
Hongdang Xu, Xin Ding, Lingrui Li, Qing Li, Zhiye Li, Hongqi Lin   +5 more
doaj   +1 more source

Nanozymes: a bibliometrics review

Journal of Nanobiotechnology
As novel multifunctional materials that merge enzyme-like capabilities with the distinctive traits of nanomaterials, nanozymes have made significant strides in interdisciplinary research areas spanning materials science, bioscience, and beyond. This article, for the first time, employed bibliometric methods to conduct an in-depth statistical analysis ...
Zihan Feng, Yuexin Guo, Yicong Zhang, Aiqin Zhang, Meng Jia, Junfa Yin, Gangyi Shen   +6 more
openaire   +3 more sources

Synthesis and Characterization of Biocompatible Manganese‐Doped Titania Nanoparticles and Its Application to Single‐Cell Nanoencapsulation

Advanced Materials Interfaces, EarlyView.
Biocompatible Mn‐doped TiO2 nanozymes integrate TiO2 stability with Mn redox activity, enabling dopamine‐mediated cell‐surface polymerization and single‐cell nanoencapsulation while maintaining high colloidal stability, low ROS generation, and excellent cellular compatibility.
Filip Kozłowski, Nayoung Kim, Hyunwoo Choi, Geoffrey Daniel, Gulaim A. Seisenbaeva, Insung S. Choi, Vadim G. Kessler   +6 more
wiley   +1 more source

Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy

, 2020
Nanozyme-based tumor catalytic therapy has attracted widespread attention in recent years. However, its therapeutic outcomes are diminished by many factors in the tumor microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H2O2 ...
Bao, Weier, Xu, Bolong, Wang, Hongyu, Qin, Meng, Wang, Weiwei, Lyu, Chengliang, Wei, Wei, Wang, Shuang, Cui, Yan, Liu, Zhen, Li, Shanshan, Liu, Huiyu   +11 more
core   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Cancer biomarker profiling using nanozyme containing iron oxide loaded with gold particles

, 2020
Nanozymes are nanomaterials with intrinsic magnetism and superparamagnetic properties. In the presence of an external magnet, nanozyme particles aggregate and redisperse without a foreign attraction.
Brown, Christopher L., Shiddiky, Muhammad JA, Brown, Christopher L, Kim, Tak H, Cock, Ian E., Cock, Ian E, Kim, Tak H., Shiddiky, Muhammad J.A., Akpe, Victor, Yamauchi, Yusuke   +9 more
core   +1 more source