Results 31 to 40 of about 9,159 (296)

Histidine modulates amyloid-like assembly of peptide nanomaterials and confers enzyme-like activity

Nature Communications, 2023
Amyloid-like assembly is not only associated with pathological events, but also leads to the development of novel nanomaterials with unique properties. Herein, using Fmoc diphenylalanine peptide (Fmoc–F–F) as a minimalistic model, we found that histidine
Ye Yuan, Lei Chen, Lingfei Kong, Lingling Qiu, Zhendong Fu, Minmin Sun, Yuan Liu, Miaomiao Cheng, Saiyu Ma, Xiaonan Wang, Changhui Zhao, Jing Jiang, Xinzheng Zhang, Liping Wang, Lizeng Gao   +14 more
doaj   +1 more source

Ultrafast synthesis of L-His-Fe3O4 nanozymes with enhanced peroxidase-like activity for effective antibacterial applications

Frontiers in Bioengineering and Biotechnology
Background: Bacterial resistance remains a significant challenge, necessitating the development of new antibacterial strategies. This study introduces a rapidly synthesized L‐histidine‐ Fe3O4 (L‐His‐Fe3O4) nanozyme with enhanced peroxidase (POD)‐like ...
Ye Yuan, Ye Yuan, Yuan Liu, Yuan Liu, Zhipeng Shen, Huidan Wu, Lantian Meng, Xiaoxiao Guo, Bing Jiang, Bing Jiang, Ling Fang, Ling Fang   +11 more
doaj   +1 more source

Single-atom nanozymes

Science Advances, 2019
Atomically mimicking the enzyme-like active sites based on nanomaterials would develop unexpected single-atom nanozymes.
Liang Huang, Jinxing Chen, Linfeng Gan, Jin Wang, Shaojun Dong   +4 more
openaire   +2 more sources

Nanozyme-based electrochemical biosensors for disease biomarker detection

, 2020
In recent years, a new group of nanomaterials named nanozymes that exhibit enzyme-mimicking catalytic activity has emerged as a promising alternative to natural enzymes.
Farhana, Fatema Zerin, Navid Kashaninejad, Shiddiky, Muhammad JA, Yoon-Bo Shim, Muhammad J. A. Shiddiky, Kashaninejad, Navid, Firoz, Shakhawat H, Mahmudunnabi, Rabbee G, Shim, Yoon-Bo, Fatema Zerin Farhana, Shakhawat H. Firoz, Rabbee G. Mahmudunnabi   +11 more
core   +1 more source

Synergistic DNA repair inhibition and genotoxic therapy in cisplatin-resistant tumors via microneedle-based co-delivery of PROTAC and Pt(IV)

Nano Research
Cisplatin resistance in tumors is closely linked to the upregulation of the nucleotide excision repair (NER) pathway, particularly the excision repair cross-complementing-1–xeroderma pigmentosum complementation group F (ERCC1–XPF) complex.
Shenghui Wang, Runze Zhao, Mingge Hou, Xiyun Yan, Bing Jiang   +4 more
doaj   +1 more source

Recent Progress on the Applications of Nanozyme in Surface-Enhanced Raman Scattering

Chemosensors, 2022
Nanozymes are nanomaterial with natural enzyme-like activity and can catalyze specific reactions for analyte identification and detection. Compared to natural enzymes, they have several benefits, including being steady, low-cost, easy to prepare and ...
Dan Li, Ling Xia, Gongke Li
doaj   +1 more source

Nanozyme-Based Bandage with Single-Atom Catalysis for Brain Trauma

, 2019
Neurotrauma is one of the most serious traumatic injuries, which can induce an excess amount of reactive oxygen and nitrogen species (RONS) around the wound, triggering a series of biochemical responses and neuroinflammation.
Wei Long (411482), Xiaoyu Mu (552544), Lufei Ouyang (6341243), Shaofang Zhang (218367), Haile Liu (6341246), Shuangjie Liu (6564320), Junying Wang (509009), Wenting Hao (7449878), Yalong Gao (6860867), Xiao-Dong Zhang (281397), Ruijuan Yan (7332416), Qifeng Li (585722), Dong Ming (401661), Si Sun (771598), Jiang Yang (626469), Junchi Chen (7449881)   +15 more
core   +1 more source

Targeted protein degradation technologies: Emerging mechanisms and nano-based innovations

Nano Research
Targeted protein degradation (TPD) technologies have emerged as a powerful strategy for eliminating disease-causing proteins by hijacking endogenous degradation systems. Over the past decade, multiple TPD modalities—such as proteolysis-targeting chimeras
Mingge Hou, Runze Zhao, Shenghui Wang, Bing Jiang, Xiyun Yan   +4 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Probiotic-based oral vaccine mucosal delivery system enabling genetically encoded dual-antigen arrays

Nature Communications
Oral vaccines provide a non-invasive approach for cancer immunotherapy but face challenges in gastrointestinal stability, antigen presentation, and mucosal delivery. Here, we present an engineered probiotic-based oral vaccine system, Bac OR-Fn-T+phiX174,
Yale Yue, Qi Xin, Yuanyuan Zhu, Dandan Zhu, Baohua Zhang, Xiyun Yan, Bing Jiang   +6 more
doaj   +1 more source