Results 71 to 80 of about 9,718 (271)

Stable peptide-assembled nanozyme mimicking dual antifungal actions

Nature Communications
Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic candidates against antimicrobial resistance but suffer from low efficiency and poor stability. Here, we develop peptide nanozymes which mimic the mode of action of AMPs
Ye Yuan, Lei Chen, Kexu Song, Miaomiao Cheng, Ling Fang, Lingfei Kong, Lanlan Yu, Ruonan Wang, Zhendong Fu, Minmin Sun, Qian Wang, Chengjun Cui, Haojue Wang, Jiuyang He, Xiaonan Wang, Yuan Liu, Bing Jiang, Jing Jiang, Chenxuan Wang, Xiyun Yan, Xinzheng Zhang, Lizeng Gao   +21 more
doaj   +1 more source

Antigen-labeled mesoporous silica-coated Au-core Pt-shell nanostructure: a novel nanoprobe for highly efficient virus diagnosis

Journal of Biological Engineering, 2019
Background As an emerging research area of artificial enzymes, nanozyme, the catalytic nanomaterials with enzyme-like characteristics, have attracted enormous attention in research.
Aiyun Li, Lin Long, Fengshou Liu, Jianbo Liu, Xiaochun Wu, Yinglu Ji   +5 more
doaj   +1 more source

Data-informed discovery of hydrolytic nanozymes

Nature Communications, 2022
Developing hydrolytic nanozymes remains challenging. Here the authors present a rational methodology to design hydrolytic nanozyme by developing a data-informed strategy to screen and identify potential scaffold and active sites of hydrolase-like ...
Sirong Li, Zijun Zhou, Zuoxiu Tie, Bing Wang, Meng Ye, Lei Du, Ran Cui, Wei Liu, Cuihong Wan, Quanyi Liu, Sheng Zhao, Quan Wang, Yihong Zhang, Shuo Zhang, Huigang Zhang, Yan Du, Hui Wei   +16 more
doaj   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy

Advanced Science
Mild‐temperature photothermal therapy (mPTT) is attractive for cancer treatment due to its safety and precision but is limited by heat shock protein 70 (HSP70)‐mediated thermotolerance, which allows tumor cells to survive sublethal heating.
Shuyu Wang, Shenghui Wang, Mengyuan Cao, Lulu Wang, Wei Jiang, Xiyun Yan, Ying Liu, Bing Jiang   +7 more
doaj   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

A Role for Nanoparticles in Treating Traumatic Brain Injury [PDF]

, 2019
Traumatic brain injury (TBI) is one of the main causes of disability in children and young adults, as well as a significant concern for elderly individuals.
Bony, Badrul Alam, Kievit, Forrest M.
core   +1 more source

Toward Supramolecular Nanozymes for the Photocatalytic Activation of Pt(IV) Anticancer Prodrugs [PDF]

, 2020
A supramolecular nanozyme for the photocatalytic conversion of a Pt(IV) anticancer complex to cisplatin is described herein. We employed 1.9 nm Au nanoparticles decorated with thiol ligands bearing a TACN (1,4,7-triazacyclononane) headgroup to ...
López Cortajarena, Aitziber, Mancin, Fabrizio, Martínez, Álvaro, Mazzei, Laura Filomena, Rosa Gastaldo, Daniele, Salassa, Luca, Trevisan, Lucia   +6 more
core   +2 more sources

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source