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Hydrolytic Nanozymes

European Journal of Organic Chemistry, 2020
In 2004 we first reported catalytic nanoparticles, that are able to cleave phosphate diesters with very high efficiency (Angew. Chem. Int Ed, 2004, 43, 6165–6169) and dubbed them “nanozymes” for the similarity of their behavior with natural enzymes, both in terms of efficiency and mechanism of action.
Gabrielli L.   +4 more
openaire   +2 more sources

Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy.

Chemical Reviews
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) in situ, thereby inducing oxidative stress and promoting cancer cell ...
Xiuna Jia, Erkang Wang, Jin Wang
semanticscholar   +1 more source

Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles

Science China Life Sciences, 2021
The iron oxide nanoparticles (IONPs) that combine the nanozyme activity and magnetothermal properties have attracted significant interest for various biomedical applications. However, the effect of magnetic stimulation in fine-tuning the nanozyme activities remains unclear.
Yuan, He   +7 more
openaire   +2 more sources

Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing

Advances in Materials
The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory and proliferative ...
Yongsen Zhao   +10 more
semanticscholar   +1 more source

Cerium Oxide Nanozymes: Exploring Synthesis, Catalytic Activity, and Biomedical Potential.

Small
Cerium oxide (CeO2) nanozymes have emerged as a novel class of nanozyme materials distinguished by their tunable valence states (Ce3+/Ce4+) and abundant surface oxygen vacancies (OVs), demonstrating exceptional chemical stability, cost-effectiveness, and
Yuyao Cai   +11 more
semanticscholar   +1 more source

Metal-organic framework-based nanozymes for water-soluble antioxidants and Total antioxidant capacity detection: Principles and applications.

Food Chemistry
Nanozymes, engineered catalysts exhibiting catalytic properties, have emerged as key players at the interface of nanotechnology and biology, holding great promise in diverse food applications.
Sameera Sh. Mohammed Ameen, K. Omer
semanticscholar   +1 more source

Copper-Based Nanozymes: Potential Therapies for Infectious Wounds.

Small
Bacterial infections are a significant obstacle to the healing of acute and chronic wounds, such as diabetic ulcers and burn injuries. Traditional antibiotics are the primary treatment for bacterial infections, but they present issues such as antibiotic ...
Haojie Ge   +4 more
semanticscholar   +1 more source

Amalgamation of DNAzymes and Nanozymes in a Coronazyme

Journal of the American Chemical Society, 2023
Artificial enzymes such as nanozymes and DNAzymes are economical and stable alternatives to natural enzymes. By coating Au nanoparticles (AuNPs) with a DNA corona (AuNP@DNA), we amalgamated nanozymes and DNAzymes into a new artificial enzyme with catalytic efficiency 5 times higher than AuNP nanozymes, 10 times higher than other nanozymes, and ...
Li Zuo   +8 more
openaire   +2 more sources

Nanozymes for Therapeutics

2020
Free radicals (ROS, NOS, etc.) play a vital role in the pathological process of many diseases from nerve and organ injury to cancer, tissue damage, and inflammatory disorders. Though moderate amount of free radicals helps maintain the normal body function and hamper the growth of bacteria, excessive amount of radicals will induce oxidative stress ...
Wen Cao   +3 more
openaire   +1 more source

Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy.

Biomaterials
Abnormal microglial activation increases inflammation, causing significant brain damage after intracerebral hemorrhage (ICH). To aid recovery, treatments should regulate oxidative stress and inhibit the M1-like phenotype (pro-inflammation) of microglia ...
Xiu-Mei Guo   +11 more
semanticscholar   +1 more source

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