Results 131 to 140 of about 4,751 (182)

The Use of Naphthoquinones and Furano-naphthoquinones as Antiinvasive Agents

Current Medicinal Chemistry, 2019
Background: Cancer is a leading cause of mortality in the world and metastasis is to blame. A number of naphthoquinones (NQs) have shown ability to reduce cancer stemness and metastatic potential. Furano-naphthoquinones (FNQs), which is a class of NQ characterized by the incorporation of an additional furan ring, have demonstrated improved anti ...
Siu Wai Tsang, Nga Yi Tsang, Ming-Zhong Wang   +2 more
exaly   +3 more sources

Naphthoquinone metabolites of the fungi

Phytochemistry, 1998
Structures and physico-chemical properties of 100 naphthoquinone metabolites produced by filamentous fungi are reviewed. The conditions of pigment formation, biogenesis and the mechanism of biosynthesis of pigments by fungi are described. Sixty-three fungi cultures able to produce naphthoquinone are listed.
A G, Medentsev, V K, Akimenko
openaire   +2 more sources

Dihydroxyacetone Naphthoquinone Sunscreen

JAMA: The Journal of the American Medical Association, 1972
To the Editor.— During the past decade, we have successfully used a sunscreen containing dihydroxyacetone/ naphthoquinone (lawsone) for patients with all types of cutaneous photosensitivity. 1 An advantage of this sunscreen is its capacity to induce a broad "ultraviolet shield" (290 to 405 nm) in the uppermost layer of the skin.
R M, Fusaro, J A, Johnson
openaire   +2 more sources

Iodinated 1,4-naphthoquinones

Russian Chemical Bulletin, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N. V. Ivashkina, E. A. Yakovleva, I. D. Ivanchikova, A. A. Moroz, M. S. Shvartsberg   +4 more
openaire   +1 more source

Potent antitumor activity of synthetic 1,2-Naphthoquinones and 1,4-Naphthoquinones

Bioorganic & Medicinal Chemistry, 2003
Rhinacanthone (1) and two 1,2-pyranonaphthoquinones (2,3) were synthesized and found to show very potent cytotoxicity against three cancer cell lines (KB, HeLa and HepG(2)) with IC(50) values of 0.92-9.63 microM, whereas the corresponding hydroxylated derivative 4 had reduced cytotoxicity (IC(50) values of 7.61-24.13 microM).
Ngampong, Kongkathip, Boonsong, Kongkathip, Pongpun, Siripong, Chak, Sangma, Suwaporn, Luangkamin, Momad, Niyomdecha, Suppachai, Pattanapa, Suratsawadee, Piyaviriyagul, Palangpon, Kongsaeree   +8 more
openaire   +2 more sources

Organocatalytic atroposelective synthesis of naphthoquinone thioglycosides from aryl-naphthoquinones and thiosugars

Chemical Communications, 2023
A stereoselective organocatalytic strategy was developed to synthesize the axially chiral naphthoquinone thioglycosides from aryl-naphthoquinones and thiosugars. The reaction pathway involves atroposelective addition and stereoretentive oxidation.
Yuling Wu, Wu-Jingyun Zhou, Laiping Yao, Yadi Niu, Hongli Zhao, Cheng Peng, Bo Han, Wei Huang, Gu Zhan   +8 more
openaire   +2 more sources

Naphthoquinone Derivatives Targeting Melanoma

Current Topics in Medicinal Chemistry, 2023
Abstract: Cancer is responsible for high mortality rates worldwide, representing a serious health problem. In this sense, melanoma corresponds to the most aggressive type of skin cancer, being the cause of the highest death rates. Therapeutic strategies for the treatment of melanoma remain limited, with problems associated with toxicity, serious side ...
Jéssica Alves Nunes, Adrielle Firmino da Silva Nunes, Dimas José da Paz Lima, Edeildo Ferreira da Silva-Júnior   +3 more
openaire   +2 more sources

1,4-Naphthoquinone

2001
[130-15-4] C10H6O2 (MW 158.16) InChI = 1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H InChIKey = FRASJONUBLZVQX-UHFFFAOYSA-N (dienophile used to synthesize various aromatic rings via Diels–Alder or cycloaddition-type reactions;1 undergoes amination,2 allylation,3 cyclooligomerization,4 and Thiele–Winter acetoxylation to give ...
Erica Caldwell, Laurent Deloux, Morris Srebnik   +2 more
openaire   +1 more source

Tubulin‐Perturbing Naphthoquinone Spiroketals

Chemical Biology & Drug Design, 2008
Several natural and synthetic naphthoquinone spiroketals are potent inhibitors of the thioredoxin–thioredoxin reductase redox system. Based on the antimitotic and weak antitubulin actions noted for SR‐7 ([8‐(furan‐3‐ylmethoxy)‐1‐oxo‐1,4‐dihydronaphthalene‐4‐spiro‐2′‐naphtho[1″,8″‐de][1′,3′][dioxin]), a library of related compounds was screened for ...
Raghavan, Balachandran, Tamara D, Hopkins, Catherine A, Thomas, Peter, Wipf, Billy W, Day   +4 more
openaire   +2 more sources

A Second Naphthoquinone in Spinach Chloroplasts

Nature, 1964
DURING the chromatography of lipids from spinach chloroplasts we have observed a compound which appears to be a form of vitamin K which is different from the well-known vitamin K1. The latter has previously been isolated from chloroplasts1,2 and is widely distributed in green plants3.
M, MCKENNA, M D, HENNINGER, F L, CRANE
openaire   +2 more sources