Results 111 to 120 of about 21,657 (219)

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

An adolescent hospitalised after polysubstance abuse: A case report

General Psychiatry, Volume 39, Issue 3, June 2026.
Haifeng Zhang, Jialong Yi, Xin Yu
wiley   +1 more source

Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review

European Journal of Neurology, Volume 33, Issue 6, June 2026.
This graphical abstract presents the review process (including 41 studies). It highlights the use of machine learning techniques in adults with CDH, such as unsupervised learning for phenotype discovery and supervised learning for diagnosis classification. The figure summarizes the strengths and limitations of each approach, along with key clinical and
Annina Helmy, Livia G. Fregolente, Marc von Gernler, Rafael Morand, Julia van der Meer, Markus Schmidt, Stavroula Mougiakakou, Athina Tzovara, Claudio L. A. Bassetti   +8 more
wiley   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

1213 A case of Narcolepsy with Cataplexy in an elderly man treated with Sodium Oxybate [PDF]

, 2017
Kalyan Muppavarapu, K Gozalez, Cory Cross, Viral Doshi   +3 more
openalex   +1 more source

Development of a lower-sodium oxybate formulation for the treatment of patients with narcolepsy and idiopathic hypersomnia [PDF]

, 2021
Gunjan Junnarkar, Clark Allphin, Judi Profant, Teresa L. Steininger, Cuiping Chen, Katie Zomorodi, Roman Skowroński, Jed Black   +7 more
openalex   +1 more source

Validation of OSLER Test Against Maintenance of Wakefulness Test and the Association With Subjective Measures of Sleepiness

Journal of Sleep Research, Volume 35, Issue 3, June 2026.
ABSTRACT The ability to stay awake is crucial in life and can be compromised by insufficient sleep and medical conditions. Measuring alertness is important for evaluating driving ability and the Oxford Sleep Resistance (OSLER) test may provide an easy way for assessment.
Riikka Huhta, Anniina Alakuijala, Markku Partinen   +2 more
wiley   +1 more source

HLA high-resolution typing by next-generation sequencing in Pandemrix-induced narcolepsy

, 2019
A. R. Lind, Omar Akel, Madeleine Wallenius, Anita Ramelius, Marlena Maziarz, Lue Ping Zhao, Daniel E. Geraghty, Lars Palm, Åke Lernmark, Helena Elding Larsson   +9 more
openalex   +2 more sources

When Being in the Minority Feels Threatening: Social Identity and the Reinforcement of Anti‐Vaccination Attitudes

Scandinavian Journal of Psychology, Volume 67, Issue 3, Page 874-890, June 2026.
ABSTRACT The present research aims to contribute to the understanding of anti‐vaccination attitudes. We do this by analyzing the role of social identity and intergroup threat. Drawing on intergroup threat theory, we hypothesize that being informed that the general population is positive toward vaccines may be perceived as threatening to individuals ...
Emma A. Renström, Hanna Bäck, Amanda Remsö   +2 more
wiley   +1 more source

Prevalence and Factors Associated with Rapid Eye Movement-Related Obstructive Sleep Apnea in Patients with Narcolepsy

Nature and Science of Sleep
Hamza O Dhafar,1 Ali A Awadh,2 Salih A Aleissi,1 Galal Eldin Abbas Eltayeb,3 Samar Z Nashwan,1 Ahmed S BaHammam1,4 1The University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2Seha ...
Dhafar HO, Awadh AA, Aleissi SA, Eltayeb GEA, Nashwan SZ, BaHammam AS   +5 more
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