Results 101 to 110 of about 38,442 (298)

Respiratory safety of lemborexant in adult and elderly subjects with moderate‐to‐severe chronic obstructive pulmonary disease

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Lemborexant 10 mg, a dual orexin‐receptor antagonist (DORA), did not elicit respiratory depressant effects, as measured by peripheral oxygen saturation (SpO2) or apnea–hypopnea index (AHI), in subjects with moderate‐to‐severe chronic obstructive pulmonary disease (COPD).
Jocelyn Y. Cheng, Daniel Lorch, Nancy Hall, Margaret Moline   +3 more
wiley   +1 more source

Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. [PDF]

, 2014
Narcolepsy is a chronic sleep disorder, likely with an autoimmune component. During 2009 and 2010, a link between A(H1N1)pdm09 Pandemrix vaccination and onset of narcolepsy was suggested in Scandinavia.
A. Cederlund, A. Huutoniemi, Adamantidis, Ahnaou, Aran, B. Agerberth, B. Horvath, Beuckmann, Bittencourt, C. Adori, Chastrette, Conzelmann, Cvetkovic-Lopes, D. Kostyalik, Dauvilliers, David, de Lecea, Diniz Behn, Frisullo, G. Bagdy, Gao, Geis, Gonzalez-Albo, Hallmayer, Han, Hara, Hublin, I. Julkunen, Israeli, Kantor, Kitka, Konadhode, Koo, Kornum, L. Kalmar, Li, Longstreth, M. Partinen, Maulon-Feraille, Mignot, NAHON, Overeem, P. Bergman, Panskepp, Partinen, Peyron, Peyron, Qiu, Rao, Rovere, S. Vas, Sakurai, Saper, Saper, Sasaki, Scammell, T. Hokfelt, T. Sarkanen, Tamamaki, Thannickal, Tsunematsu, van den Pol, Verret, Viale, Watson, Y. Kai-Larsen, Zhang   +66 more
core   +1 more source

Narcolepsy initially misdiagnosed as schizophrenia: A case report

Sleep Research, EarlyView.
Feng Daoyi, Liu Xin, Xu Rui, He Lihua
wiley   +1 more source

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Relationship between T-cell receptor α gene polymorphisms and symptomatic differences in patients with narcolepsy type 1

Chinese Medical Journal, 2019
. Background:. Recent genome-wide association studies have identified an important role of T-cell receptor α (TRA) gene in the development of narcolepsy type 1.
Hui Ouyang, Fang Han, Ze-Chen Zhou, Qi-Wen Zheng, Yang-Yang Wang, Jun Zhang, Qiang Shi   +6 more
doaj   +1 more source

Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy [PDF]

, 2014
Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. The exact cause remains unknown, but there is significant evidence that hypocretin deficiency plays an ...
Mustafa Gulec, Pinar Guzel Ozdemir, Tezay Cakin Gulec, Yavuz Selvi   +3 more
core   +1 more source

Validation of OSLER Test Against Maintenance of Wakefulness Test and the Association With Subjective Measures of Sleepiness

Journal of Sleep Research, EarlyView.
ABSTRACT The ability to stay awake is crucial in life and can be compromised by insufficient sleep and medical conditions. Measuring alertness is important for evaluating driving ability and the Oxford Sleep Resistance (OSLER) test may provide an easy way for assessment.
Riikka Huhta, Anniina Alakuijala, Markku Partinen   +2 more
wiley   +1 more source

Pituitary Macrotumor Causing Narcolepsy‐Cataplexy in a Dachshund

Journal of Veterinary Internal Medicine, 2017
Familial narcolepsy secondary to breed‐specific mutations in the hypocretin receptor 2 gene and sporadic narcolepsy associated with hypocretin ligand deficiencies occur in dogs.
S. Schmid, A. Hodshon, S. Olin, I. Pfeiffer, S. Hecht   +4 more
doaj   +1 more source

Pandemic influenza vaccine & narcolepsy: Simulations on the potential impact of bias [PDF]

, 2016
Several studies have identified an association between PandemrixTM, an AS03 adjuvanted pandemic influenza A(H1N1) vaccine, and narcolepsy, a rare and under-diagnosed sleep disorder with a median onset-to-diagnosis interval of ten years.
Black, S. (Steve), Bonhoeffer, J. (Jan), Dodd, C.N. (Caitlin), Lammers, G.J. (Gert Jan), Overeem, S. (Sebastiaan), Ridder, M.A.J. (Maria) de, Romio, S.A. (Silvana), Sturkenboom, M.C.J.M. (Miriam), Weibel, D.M. (Daniel), Wijnans, E.G. (Leonoor)   +9 more
core   +1 more source

Cyclic hypersomnolence with symptoms of narcolepsy with cataplexy: An unusual presentation of probable immune-mediated encephalitis

eNeurologicalSci, 2018
We report a case of probable encephalitis presenting as narcolepsy with cataplexy, but with cyclical exacerbation and cognitive difficulties. Our patient continued to worsen despite treatment for narcolepsy and later was thought to have an immune ...
Rafer Willenberg, Jonathan D. Bui
doaj   +1 more source