Results 81 to 90 of about 15,506 (210)

Differences in Sleep Spindle Characteristics Between Children With Narcolepsy and Those With Other Causes of Subjective Sleepiness

Journal of Sleep Research, EarlyView.
ABSTRACT Central disorders of hypersomnolence are characterised by excessive daytime sleepiness. There has been growing interest in analysing sleep micro‐architecture, to further understand how sleep is affected by these conditions. We investigated if sleep spindle activity differed between children with narcolepsy, idiopathic hypersomnolence (IH) and ...
Marisha Shetty, Nushrika Kadam Kishore, Georgina Plunkett, Lauren C. Nisbet, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne   +7 more
wiley   +1 more source

Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life

Journal of Sleep Research, EarlyView.
Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life. ABSTRACT In the central disorders of hypersomnolence (CDH) narcolepsy types 1 and 2 (NT1, NT2) and idiopathic hypersomnia (IH), mental health problems are highly prevalent, and quality of life is decreased.
Denise Bijlenga, Tessa F. Blanken, Josephine J. de Boer, Rolf Fronczek, Gert Jan Lammers   +4 more
wiley   +1 more source

Impaired Alertness Correlates With Chronic Anxiety: A Prospective Tertiary University Centre Cohort

Journal of Sleep Research, EarlyView.
ABSTRACT The Maintenance of Wakefulness Test (MWT) is a widely used objective measure of daytime alertness, especially in patients with sleep disorders at increased risk of accidents. Anxiety and depression are common in this population and may influence subjective sleepiness and objective alertness.
Anice Borjon, Lucie Bobin, François Ricordeau, Lucas Marces, Hugo Fornelli, Thierry Petitjean, Amandine Viccica, Elena Charbonnier, Emeric Stauffer, Barbara Charbotel, Jacques Taillard, Renaud Tamisier, Laure Peter‐Derex, Pierre Tankéré   +13 more
wiley   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Plant‐Based Production of Human Major Histocompatibility Complex Class II Molecules

Plant Biotechnology Journal, EarlyView.
ABSTRACT Major histocompatibility complex class II (MHC II) protein triggers adaptive immune responses by presenting antigens on antigen‐presenting cells (APCs) to be recognised by CD4+ T cells. Recombinant MHC II proteins are effective for the analysis of peptide‐binding interaction, detection of antigen‐specific T‐cells and clinical testing for donor‐
Abdelaziz Ramadan, Hiroko Miyadera, Kaho Oka, Kohei Ishikawa, Toshiya Kobayashi, Misaki Kobayashi, Mitsunori Shiroishi, Emiko Noguchi, Kenji Miura   +8 more
wiley   +1 more source

Using an Adapted Job Demands–Resources Model to Examine the Use of Legal, Prescription, and Illegal Drugs for Cognitive Enhancement in the Working Population in Germany

Sociological Inquiry, EarlyView.
Chronic stress is a global issue with detrimental effects on health and productivity, often leading individuals to adopt health‐related coping strategies. This study uses an adapted Job Demands–Resources model to examine how various job demands and resources impact perceived stress and, consequently, the use of legal, prescription, and illegal drugs ...
Sebastian Sattler, Mareike Reimann, Myriam Baum, Nina Hänel   +3 more
wiley   +1 more source

Salivary biomarkers in sleep‐related disorders

Sleep Research, Volume 3, Issue 3, Page 272-285, September 2026.
Abstract The exploration of salivary biomarkers has emerged as a promising avenue in the diagnosis and management of sleep‐related disorders, such as obstructive sleep apnea (OSA), insomnia, and sleep deprivation. Saliva is a noninvasive biofluid that contains a wealth of biological markers, reflecting both local and systemic physiological changes ...
Chuan Xiang Li, Yi Wang, Ying Ni Lin, Jun Qi Lin, Ya Ru Yan, Xian wen Sun, Liu Zhang, Shi Qi Li, Ning Li, Qing Yun Li   +9 more
wiley   +1 more source

Comparative potential for generating spontaneous signals for abuse and dependence among drugs used for attention deficit hyperactivity disorder: A disproportionality analysis in VigiBase®

General Psychiatry, Volume 39, Issue 4, August 2026.
ABSTRACT Background The comparative liability for abuse and dependence of drugs used for attention deficit hyperactivity disorder (ADHD) has been poorly explored so far. Aims To evaluate the relative potential of medications used for ADHD for generating spontaneous reports of abuse and dependence in international pharmacovigilance data.
Emilie Jouanjus, Tiffanie Grime, Constance Bordet, Maryse Lapeyre‐Mestre, Benjamin Rolland   +4 more
wiley   +1 more source

Narcolepsy Is Associated With Subclinical Cardiovascular Disease as Early as Childhood: A Big Data Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Narcolepsy is linked to adverse cardiovascular disease (CVD) outcomes, but few studies have examined its associations with subclinical CVD, including in children.
Christopher N. Kaufmann, Munaza Riaz, Haesuk Park, Wei‐Hsuan Lo‐Ciganic, Debbie Wilson, Emerson M. Wickwire, Atul Malhotra, Rakesh Bhattacharjee   +7 more
doaj   +1 more source

A randomized trial of I‐SLEEP: A patient education and empowerment intervention on inpatient sleep duration and medical sleep disruptions

Journal of Hospital Medicine, Volume 21, Issue 8, Page 881-889, August 2026.
Visual Abstract Abstract Background Sleep is essential for recovery in hospitalized patients, yet frequent disruptions from medical care make rest difficult. Most prior efforts have focused on environmental modifications, often overlooking patients' role in advocating for their sleep.
Aashna Sunderrajan, John Cursio, Noah Mason, Maxx Byron, Maylyn Martinez, Nicola Orlov, Kristen L. Knutson, Babak Mokhlesi, Valerie G. Press, David O. Meltzer, Vineet M. Arora   +10 more
wiley   +1 more source