Results 71 to 80 of about 38,442 (298)

Narcolepsy: an interface among neurology, immunology, sleep, and genetics

Arquivos de Neuro-Psiquiatria
Narcolepsy is a primary disorder of the central nervous system resulting from genetic, environmental, and immunological interactions defined as excessive daytime sleepiness plus cataplexy, hallucinations, sleep paralysis, and sleep fragmentation.
Fernando Morgadinho Santos Coelho
doaj   +1 more source

Risk of immunotherapy-related narcolepsy in genetically predisposed patients: a case report of narcolepsy after administration of pembrolizumab

Journal for ImmunoTherapy of Cancer, 2020
Background Immune-related adverse events associated with immune checkpoint therapy cause autoimmune disease-like symptoms. People who carry specific genotypes or haplotypes of human leucocyte antigen (HLA) are known to be predisposed to develop ...
Shigehira Saji, Emi Tokuda, Takashi Kanbayashi, Yutaka Natori, Eisaku Sasaki, Shu Soeda, Shigenori Furukawa, Yusuke Azami   +7 more
doaj   +1 more source

Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2". [PDF]

, 2015
Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children, as suggested by Ahmed et al.? Using newly developed mouse models to report and inactivate hypocretin receptor expression, Vassalli et ...
Li, S., Tafti, M., Vassalli, A.
core   +1 more source

Missense Variants in the A Isoform of FGF13 as a Novel Cause of Paroxysmal Dyskinesia

Movement Disorders, EarlyView.
Abstract Background Pathogenic variants within the unique N‐terminal inactivation particle of FGF13 isoform A (FGF13A) have so far been associated only with an X‐linked dominant epileptic encephalopathy (DEE). Objective The aim was to expand the clinical and molecular spectrum of FGF13A‐related disorder.
Cyril Mignot, Matthildi Athina Papathanasiou Terzi, Claudia Ravelli, Elisabeth Bosch, Xueqin Lin, Adeline Trauffler, Roseline Caumes, Andrew E. Fry, Clementine Fort, Gaelle Gauthe, Regina Trollmann, Thomas Wirth, Mathieu Anheim, Aurélie Méneret, Emmanuel Roze, Jean‐Madeleine de Sainte Agathe, Hailan He, Eleni Panagiotakaki, Gaëtan Lesca, André Reis, Diane Doummar, Thomas Smol, Georgia Vasileiou   +22 more
wiley   +1 more source

IgG abnormality in narcolepsy and idiopathic hypersomnia. [PDF]

PLoS ONE, 2010
BACKGROUND: A close association between narcolepsy and the Human Leukocyte Antigen (HLA)-DQB1*0602 allele suggests the involvement of the immune system, or possibly an autoimmune process. We investigated serum IgG levels in narcolepsy.
Susumu Tanaka, Makoto Honda
doaj   +1 more source

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture [PDF]

, 2007
We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to GABA_A receptor agonists due to a ...
Bernard Bettler, Hitomi Takahira, Ken-ichi Yagami, Masashi Yanagisawa, Mika Nomiyama, Noriko Hirashima, Satoru Takahashi, Satoshi Kunita, Taizo Matsuki, Takeshi Sakurai, Thomas Kilduff   +10 more
core   +1 more source

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. [PDF]

, 2013
The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala ...
Behnke, Eric J, Blouin, Ashley M, Fried, Itzhak, Karlsson, Karl Æ, Lam, Hoa A, Lapierre, Jennifer L, Maidment, Nigel T, Siegel, Jerome M, Staba, Richard J, Wilson, Charles L   +9 more
core   +1 more source

Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea (OSA) is a common chronic disorder characterized by abnormal breathing during sleeping. OSA can damage various organs throughout the body and is burdensome, both socially and economically. Moreover, as OSA has been increasingly studied in recent years, new evidence‐based guidelines for its diagnosis and surgical ...
Working Group of Guideline for the Diagnosis and Surgical Treatment of Adult OSA, Subspecialty Group of Laryngopharyngology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association, Subspecialty Group of Voice, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery   +7 more
wiley   +1 more source

Central disorders of hypersomnolence in children and adults: A comparative study from South India

Annals of Indian Academy of Neurology, 2019
Background: Narcolepsy and idiopathic hypersomnolence (IHS) are rare disorders. In Western populations, the reported prevalence of narcolepsy is 0.02%–0.05%. In Indian subcontinent, there are few reports on narcolepsy and none on IHS so far.
Madhukar Trivedi, Sapna Erat Sreedharan, Shana N Nair, C A Anees, J P Unnikrishnan, P S Sarma, Ashalatha Radhakrishnan   +6 more
doaj   +1 more source

Symptomatic Narcolepsy and Generalized Seizures Following Surgery for Rathke’s Cleft Cyst [PDF]

Sleep Medicine Research, 2014
Symptomatic narcolepsy is a rare disorder caused by other underlying neurological disorders. One of the most frequent causes for symptomatic narcolepsy is brain tumors, usually in the region of the third ventricle and the diencephalon.
On-Hwa Ryu, Han Uk Ryu, Sang-Ahm Lee
doaj   +1 more source