Results 131 to 140 of about 43,002 (287)

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Robots, drugs, reality and education: how the future will change how we think [PDF]

, 2009
Emerging technologies for learning report - Article exploring various future trends and their potential impact on ...
Sandford, Richard
core  

Relato de dois casos de pacientes com narcolepsia com melhora dos sintomas após uso de prednisona [PDF]

, 2007
This article focuses on 2 clinical case reports of narcoleptic patients who experienced an absence of excessive sleepiness during treatment of other illnesses with 40 mg daily intake of prednisone.Este artigo refere-se à discussão de 2 casos de pacientes
Alves, Gabriela Rodrigues, Bittencourt, Lia Rita Azeredo, Coelho, Fernando Morgadinho Santos, Pradella-Hallinan, Márcia Lurdes de Cássia, Tufik, Sergio   +4 more
core   +2 more sources

Validation of OSLER Test Against Maintenance of Wakefulness Test and the Association With Subjective Measures of Sleepiness

Journal of Sleep Research, EarlyView.
ABSTRACT The ability to stay awake is crucial in life and can be compromised by insufficient sleep and medical conditions. Measuring alertness is important for evaluating driving ability and the Oxford Sleep Resistance (OSLER) test may provide an easy way for assessment.
Riikka Huhta, Anniina Alakuijala, Markku Partinen   +2 more
wiley   +1 more source

Narcolepsy: a review

Neuropsychiatric Disease and Treatment, 2011
Gbolagade Sunmaila Akintomide1, Hugh Rickards21Department of Neuropsychiatry, University of Birmingham, 2Department of Neuropsychiatry, The Barberry, Edgbaston, Birmingham, UKAbstract: Narcolepsy is a lifelong sleep disorder characterized by a classic ...
Akintomide GS, Rickards H
doaj  

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland

Journal of Sleep Research, EarlyView.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Rafael Morand, Livia Fregolente, Julia van der Meer, Elena S. Wenz, Annina Helmy, Lorenzo Brigato, Jan D. Warncke, Kseniia Zub, Ramin Khatami, Zhongxing Zhang, Sigrid von Manitius, Silvia Miano, Jens Acker, Mathias Strub, Ulf Kallweit, Gert Jan Lammers, Athina Tzovara, Claudio L. A. Bassetti, Stavroula Mougiakakou, Markus H. Schmidt   +19 more
wiley   +1 more source

Estudo dos linfócitos T CD4, CD8 e B em pacientes com narcolepsia [PDF]

, 2007
Narcolepsy is characterized by excessive daytime sleep and cataplexy. Little is known about the possible difference in pathophysiology between patients with or without cataplexy.
Alves, Gabriela Rodrigues, Bittencourt, Lia Rita Azeredo, Coelho, Fernando Morgadinho Santos, Moreira, Fábio, Pedrazzoli, Mario, Pradella-Hallinan, Márcia Lurdes de Cássia, Tufik, Sergio   +6 more
core   +3 more sources

Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non‐Diabetic Hyperglycaemia

Journal of Sleep Research, EarlyView.
ABSTRACT Insomnia may play a causal role in type 2 diabetes (T2D). Addressing insomnia through cognitive behavioural therapy (CBTi) in people with non‐diabetic hyperglycaemia could potentially reduce the risk of progression to T2D. To inform a future randomised trial, we performed a feasibility study of digital CBT (dCBTi) in individuals at increased ...
Rachel Sharman, David Ray, Andrew Farmer, Poppy C. E. Green, Victoria Harris, Fredrik Karpe, Colin A. Espie, Diana Mantripp, Thomas Marjot, Niall M. McGowan, Jeremy W. Tomlinson, Simon D. Kyle   +11 more
wiley   +1 more source

No Evidence for Seasonal Variations in Fatigue, Sleepiness and Insomnia Symptoms: Spring Fatigue Is a Cultural Phenomenon Rather Than a Seasonal Syndrome

Journal of Sleep Research, EarlyView.
ABSTRACT Although not as prominent as in other animals, humans also experience seasonal variations in sleep duration and circadian processes. These variations are likely primarily driven by changes in photoperiod length. Anecdotally, many people report experiencing fatigue and low energy levels, particularly during spring in Germany, Switzerland and ...
Christine Blume, Albrecht Vorster
wiley   +1 more source