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Narcolepsy

Journal of Sleep Research, 2022
SummaryThis article addresses the clinical presentation, diagnosis, pathophysiology and management of narcolepsy type 1 and 2, with a focus on recent findings. A low level of hypocretin‐1/orexin‐A in the cerebrospinal fluid is sufficient to diagnose narcolepsy type 1, being a highly specific and sensitive biomarker, and the irreversible loss of ...
Lucie Barateau   +3 more
openaire   +2 more sources

Narcolepsy

Southern Medical Journal, 2003
Narcolepsy is a severely debilitating neurologic disease that is not as rare as many believe, affecting an estimated 140,000 Americans. Despite the sometimes debilitating nature of narcolepsy symptoms, the disease may go undiagnosed without an organized method for evaluating patients with sleep complaints.
Tohru, Kodama, Yasuro, Takahashi
  +6 more sources

NARCOLEPSY

Southern Medical Journal, 1945
An unusual opportunity presented itself for the study of narcolepsy in a combat soldier. This patient began to have symptoms in 1935, and his disorder was not recognized correctly in premilitary life or in the precombat period of his military career. As a result he went through two long campaigns in the Mediterranean Theater of Operations.
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NARCOLEPSY

Neurologic Clinics, 1996
Narcolepsy is among the leading causes of excessive daytime sleepiness and is the most common neurologic cause. Its classic form--narcolepsy with cataplexy--is a distinct neurologic disease with characteristic clinical and paraclinical findings.
C, Bassetti, M S, Aldrich
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Narcolepsy

2010
Narcolepsy is the specific syndrome of daytime sleepiness with cataplexy, where there is a sudden loss of muscle tone—often provoked by the anticipation of emotions—leading to a tendency to fall, mouth opening, dysarthria or mutism, and facial muscle jerking.
openaire   +3 more sources

Narcolepsy

Nursing Clinics of North America, 2002
Narcolepsy is a chronic disorder of EDS. All patients experience EDS. Other symptoms include cataplexy, sleep paralysis, hypnagogic hallucinations, and disrupted nocturnal sleep. Treatment, usually with stimulants and low-doses of antidepressant medications, can dramatically improve the patient's quality of life.
Ann E, Rogers, H Michael, Dreher
openaire   +2 more sources

Pediatric narcolepsy

Brain and Development, 2008
Narcolepsy is a disabling disease with a prevalence of 0.05%. It is characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnogogic hallucinations, automatic behavior, and disrupted nocturnal sleep. The presentation can be very variable, making diagnosis difficult.
Paul C, Peterson, Aatif M, Husain
openaire   +2 more sources

Narcolepsy Update

Mayo Clinic Proceedings, 1990
Narcolepsy, a disorder of excessive daytime sleepiness that affects more than 125,000 people in the United States, is technically defined as a daytime mean sleep latency (time elapsed before falling asleep) of less than 5 minutes in conjunction with verification of rapid eye movement sleep in at least two of five daytime nap periods.
J W, Richardson   +2 more
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Childhood narcolepsy

Neurology, 1998
Narcolepsy may present during childhood and is probably underrecognized and underdiagnosed in this population. The core symptoms of narcolepsy in children are similar to those in adults, but the expression may be different because of maturational factors.
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