Results 41 to 50 of about 129,991 (344)

Limited post-operative narcotic use in elective laparoscopic cholecystectomy [PDF]

open access: yes, 2017
Purpose: To limit narcotics use Cochrane review: multiple studies have shown postoperative pain can be managed with non-narcotic meds with good outcome Less medication related side effects:N/V, constipation, disorientation Prevents substance addiction ...
Josloff, MD, Robert   +3 more
core   +1 more source

Gabapentin for pain management after osmotic dilator insertion and prior to dilation and evacuation: A randomized controlled trial. [PDF]

open access: yes, 2020
ObjectiveTo evaluate if gabapentin 600 mg reduces pain after osmotic dilator placement the day before a dilation and evacuation (D&E) procedure.Study designWe conducted a double-blind, placebo-controlled, randomized (stratified by vaginal parity ...
Chen, Melissa J   +5 more
core   +3 more sources

Tourniquetless Total Knee Arthroplasty With Modern Perioperative Protocols Decreases Pain and Opioid Consumption in Women [PDF]

open access: yes, 2018
Background This study examined whether a modern total knee arthroplasty (TKA) protocol without a tourniquet results in less patient-reported pain and in-hospital opioid consumption compared to TKA with a tourniquet.
Dilley, Julian E.   +4 more
core   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

open access: yesAdvanced Science, EarlyView.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li   +8 more
wiley   +1 more source

Density Functional Theory–Spectroscopy Integrated Identification Method Encompassing Experimental and Theoretical Analyses for Designer Drug Stimulants

open access: yesAdvanced Intelligent Systems, EarlyView.
A novel approach integrates gas chromatography‐mass spectrometry with infrared, Raman, and nuclear magnetic resonance spectroscopy plus density functional theory to detect synthetic drugs. Quantum hyperpolarization further boosts NMR sensitivity for low‐concentration samples, improving detection accuracy in complex mixtures and offering promising ...
Keunhong Jeong   +8 more
wiley   +1 more source

Contribution of Addictovigilance data to assess adverse‐events linked to psychoactive substances in children and adolescents

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims We sought to characterize adverse events and deaths associated with the use of psychoactive substances in children and adolescents. Methods Two French Addictovigilance databases were analysed: spontaneous reports and deaths over the period 2016–2021, in subjects aged 10–<18 years. An unsupervised classification was implemented on consumption data (
Hélène Peyrière   +13 more
wiley   +1 more source

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

open access: yesCell Death and Disease
Neuroinflammation is a key factor in the pathogenesis of Parkinson’s disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. However, the role of peripheral
Wei Song   +7 more
doaj   +1 more source

FEATURES OF STORAGE AND TRANSPORTATION OF NARCOTIC ANALGESICS IN CONDITIONS OF EMERGENCY SITUATIONS

open access: yesФармация и фармакология (Пятигорск), 2015
The article performs the analysis of the current state regulatory-legal framework relating to the use of narcotic analgesics in health care institutions in emergencies peace and wartime.There are developed recommendations for adapting the requirements ...
P. V. Oliynyk, B. P. Hromovyk
doaj   +1 more source

Biodegradable polymeric prodrugs of naltrexone [PDF]

open access: yes, 1991
The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the ¿-amino acids N5-(3-hydroxypropyl--glutamine
Adams, N.W.   +5 more
core   +2 more sources

On Narcotics [PDF]

open access: yesThe Boston Medical and Surgical Journal
n ...
openaire   +2 more sources

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