Results 141 to 150 of about 558,994 (238)

Narcotic Antagonists as Analgesics

Science, 1962
2-Dimethylallyl-5,9-dimethyl-2′-hydroxybenzomorphan (Win 20,228) was found to be a weak antagonist of morphine and meperidine, whereas 2-allyl-5-ethyl-2′-hydroxy-9-methyl-6,7-benzomorphan (Win 19,362) and 2-allyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan (Win 19,631) were about three times as potent as nalorphine.
S, ARCHER, N F, ALBERTSON, L S, HARRIS, A K, PIERSON, J G, BIRD, A S, KEATS, J, TELFORD, C N, PAPADOPOULOS   +7 more
openaire   +2 more sources

CLINICAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS*

Annals of the New York Academy of Sciences, 1978
Both naloxone and naltrexone are effective narcotic antagonists with minimal agonistic effects and a wide margin of safety. Naloxone is useful in the treatment of narcotic overdose and it is helpful in the quantification of physical dependence. Naltrexone is pharmacologically successful as an orally effective, long-acting antagonist but its clinical ...
C P, O'Brien, R, Greenstein, J, Ternes, G E, Woody   +3 more
openaire   +2 more sources

COMPARATIVE STUDIES WITH NARCOTICS AND NARCOTIC ANTAGONISTS IN MAN

Acta Anaesthesiologica Scandinavica, 1964
ZUSAMMENFASSUNGBei 240 oberflächlich anaesthesierten Patienten, die keine Narkotika als Prämedikation erhalten hatten, wurden die Wirkungen auf Atmung und Kreislauf der folgenden Mittel, allein oder in verschiedenen Kombinationen verabreicht, untersucht: Morphin (0,2 oder 0,3 mg/kg), Oxymorphon(20 μ/kg),Levorphan (50μ/kg),Meperidin (1,5 und 2,0 mg/kg ...
F F, FOLDES, T A, TORDA
openaire   +2 more sources

Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists

Journal of Medicinal Chemistry, 1975
A series of new narcotic antagonists has been synthesized by modifying the C-6 carbonyl group in naloxone (Ia) and naltrexone (Ib). New functional units were introduced by reaction with various phosphorus and sulfur ylides and alkyllithium reagents.
R D, Heilman, E F, Hahn, J, Fishman
openaire   +2 more sources

EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES*

Annals of the New York Academy of Sciences, 1976
Multiple and single drug interactions were studied in morphine-dependent monkeys whose dependency was maintained by self-infusion. Naloxone, naltrexone, and cyclazocine precipitated abstinence syndrome which the animals generally controlled with increased morphine intake.
K F, Killam, M J, Brocco, C A, Robinson
openaire   +2 more sources

Narcotic Antagonists: A Reasonable Method of Treating Narcotic Dependency

International Journal of the Addictions, 1975
Historically, narcotic dependence has been treated primarily by substituting one narcotic drug for another. One alternative chemical treatment for narcotic dependency is through the use of a narcotic antagonist. The present study involves the observed side effects and outcome results of treating 40 male heroin addicts with the narcotic antagonist ...
K G, Schooff, R G, Hersch, J F, Keegan
openaire   +2 more sources

STRUCTURAL FEATURES ASSOCIATED WITH NARCOTICS AND NARCOTIC ANTAGONISTS

Neuropharmacology, 1975
Viminol shares many pharmacological properties of the traditional narcotics, but it differs from the latter because it has an extremely reduced capacity for producing physical dependence. This chapter discusses the types of pharmacological activity related to the structural features of the Viminol stereoisomers.
openaire   +2 more sources

Discriminative Properties of Narcotic Antagonists

1977
There have been many recent reports characterizing the discriminative properties of morphine and related narcotic analgesics in a variety of experimental paradigms, predominantly in the rat (see preceding chapter). It is becoming increasingly evident that a strong association exists between the discriminative properties of these drugs in animals and ...
S G, Holtzman, H E, Shannon, G J, Schaefer   +2 more
openaire   +2 more sources

Clinical Principles for the Narcotic Antagonists

Postgraduate Medicine, 1957
(1957). Clinical Principles for the Narcotic Antagonists. Postgraduate Medicine: Vol. 22, No. 6, pp. 566-571.
M S, SADOVE, M J, SCHIFFRIN
openaire   +2 more sources

Studies of EN-1639A (naltrexone): a new narcotic antagonist.

American Journal of Psychiatry, 2015
R. Resnick, J. Volavka, A. Freedman, M. Thomas   +3 more
semanticscholar   +1 more source