Results 41 to 50 of about 562,340 (252)

Interaction of the Opiate and Neuroendocrine Systems [PDF]

, 2011
Opiates are known to produce various physiological effects. Our understanding of these effects has been greatly increased by the discovery of the opiate receptor and the endogenous opioid peptides.
DeMaria, Jr, MD, Peter
core   +1 more source

Confronting medical grifting: Fraudulent and unproven products and interventions in apheresis, transfusion and biotherapies

British Journal of Haematology, EarlyView.
A basic overview of medical grifting for haematologists with practical guidance in identification and tips for management. Summary Medical scams or grifting has long been a societal issue, though in recent years, the problem has become increasingly mainstream, especially as it relates to transfusion medicine, apheresis and biotherapies.
Brian D. Adkins, Sheharyar Raza, Victoria Costa, Elizabeth S. Allen, Laura D. Stephens, Jennifer S. Woo, Garrett S. Booth, Jeremy W. Jacobs   +7 more
wiley   +1 more source

Does cost sharing really reduce inappropriate prescriptions? [PDF]

, 2010
This paper explores different empirical strategies to examine the effect of cost sharing for prescription drugs in some dimensions of medication-related quality, namely the probability of inappropriate prescription drug use among United States seniors ...
Costa-i-Font, Joan, Gemmill-Toyama, Marin   +1 more
core  

Memantine increases NMDA receptor level in the prefrontal cortex but fails to reverse apomorphine-induced conditioned place preference in rats [PDF]

, 2018
Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective.
Baxter BL, Gluckman MI, Stein L, et al., Bisaga A, Comer SD, Ward AS, et al., Campbell JC, Jeyamohan SB, De LCP, et al., Chen G, Greengard P, Yan Z, Chen SL, Tao PL, Chu CH, et al., Di CP, Everitt BJ, Dos SER, Daval J, Koziel V, et al., El-Bachá RS, Netter P, Minn A, Haleem DJ, Ikram H, Haleem MA, Kelley AE, Kemp JA, Mckernan RM, Overton PG, Clark D, Papp M, Parsons CG, Popik P, Layer RT, Skolnick P, Popik P, Skolnick P, Popik P, Wrobel M, Bisaga A, Sam E, Verbeke N, Sattler R, Tymianski M, Singh N, Pillay V, Choonara YE, Spyraki C, Fibiger HC, Phillips AG, Téllez C, Bustamante ML, Toro P, et al., Uys JD, Lalumiere RT, Van dKD, Swerdlow NR, Koob GF, Volkow ND, Fowler JS, Wang GJ, et al., Wu PH, Mihic SJ, Liu JF, et al., Zweifel LS, Argilli E, Bonci A, et al.   +26 more
core   +2 more sources

Behavioural Effects and Naloxone Effectiveness With New Synthetic Opioids

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The global drug market has seen an emergence of potent synthetic opioids, including benzimidazole‐derived substances known as nitazenes. These compounds have been implicated in fatal and non‐fatal overdoses. This review aims to synthesise current evidence on the pharmacological effects, potency and naloxone responsiveness of new ...
Suzanne Nielsen, João Pedro Silva, Jermaine D. Jones, Alex Krotulski, Dilkushi Poovendran, Deusdedit Muzangizi, Gilles Forte, Jason White, Sandra D. Comer   +8 more
wiley   +1 more source

A closer look at Doleac and Mukherjee (2022) and the effects of naloxone access laws on opioid ER admissions

Economic Inquiry, EarlyView.
Abstract In their 2022 study, ‘The Effects of Naloxone Access Laws on Opioid Abuse, Mortality, and Crime,’ Doleac and Mukherjee conclude that broadening access to a life‐saving drug—naloxone—does not reduce opioid‐related mortality as the drug simultaneously encourages riskier drug use. I show issues with their data, design, and estimation methods. For
Sergey Alexeev
wiley   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

Use of antimigraine medication before pregnancy and in the first trimester: A cross‐sectional study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Migraine is common among women, particularly during their reproductive years. There is limited research on the use of antimigraine medication before and during pregnancy. This study was undertaken to describe the use of antimigraine medication 3 months before pregnancy and in the first trimester among women with migraine ...
Stine Wieland, Marie S. Emborg, Mie G. de Wolff, Peter Damm, Line Buchgreitz, Mona A. Chalmer, Hanne K. Hegaard, Ane L. Rom   +7 more
wiley   +1 more source

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity [PDF]

, 2012
Background: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, and may dissolve in cell ...
Beguin, Cecile Andree, Berry, Loren M, Carlezon, William A., Carroll, F Ivy, Cohen, Bruce Michael, Munro, Thomas A, Van't Veer, Ashlee Victoria, Zhao, Zhiyang   +7 more
core   +1 more source

Uneven Product Diversification: Explaining the Lag of Agricultural Economies

International Economic Review, EarlyView.
ABSTRACT This paper documents that agricultural sectors diversify less than other manufacturing activities. A simple model shows that this difference can contribute to welfare divergence in a way that is qualitatively different to what results when uneven growth happens in the intensive margin.
Guzmán Ourens
wiley   +1 more source