Results 51 to 60 of about 13,397 (249)
Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]
, 1995 Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core +1 more source
Orphan crops of archaeology‐based crop history research
PLANTS, PEOPLE, PLANET, EarlyView.Agrobiodiversity is central to sustainable farming worldwide. Cultivation, conservation and reintroduction of diverse plant species, including ‘forgotten’ and ‘underutilized’ crops, contribute to global agrobiodiversity, living ecosystems and sustainable food production.
Daniel Fuks +23 more
wiley +1 more source
Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl [PDF]
, 1990 Morphine typically produces analgesia in a variety of species by acting as an agonist at mu and perhaps delta opioid receptors. Recent research, however, has identified a biological model in which morphine produces a naloxone-reversible, paradoxical ...
Sufka, Kenneth Joseph
core +2 more sources
Sustainable Development, EarlyView.ABSTRACT Operationalizing the indivisibility and integrated nature of the UN 2030 Agenda poses a complex governance challenge. Although research has advanced our understanding of SDG localization and interlinkages, important gaps remain. In this paper, we depart from these two strands of literature by asking how synergies and trade‐offs manifest in ...
Sara Gottenhuber +3 more
wiley +1 more source
Coordination on Time-Varying Antagonistic Networks [PDF]
arXiv, 2021 This paper studies coordination problem for time-varying networks suffering from antagonistic information, quantified by scaling parameters. By such a manner, interacting property of the participating individuals and antagonistic information can be quantified in a fully decoupled perspective, thus benefiting from merely directed spanning tree ...
arxiv
Application and Assessment of Deep Learning for the Generation of Potential NMDA Receptor Antagonists [PDF]
, 2020 Uncompetitive antagonists of the N-methyl D-aspartate receptor (NMDAR) have demonstrated therapeutic benefit in the treatment of neurological diseases such as Parkinson's and Alzheimer's, but some also cause dissociative effects that have led to the synthesis of illicit drugs.
arxiv +1 more source
The antagonism of narcotics by L-3-Hydroxy-N-Allylmorphinan (Levallorphan) L-3-Hydroxy-N-Propargylmorphinan (Propallorophan) and 2,4-Diamino-5-Phenylthiazole (Daptazole) [PDF]
, 1957 Thesis (Ph.D.)--Boston UniversityIn this study, propallorphan (a-3-hydroxy-N-propargylmorphina.n, Ro-1-7780) was found to be a potent alphaprodine to alphaprodine in both dog and man.
Megirian, Robert
core
Identification of a Novel “Almost Neutral” Mu Opioid Receptor Antagonist in CHO Cells Expressing the Cloned Human Mu Opioid Receptor [PDF]
, 2010 The basal (constitutive) activity of G protein-coupled receptors allows for the measurement of inverse agonist activity. Some competitive antagonists turn into inverse agonists under conditions where receptors are constitutively active.
Bilsky, Edward J. +12 more
core +1 more source
Strategic Management Journal, EarlyView.Abstract Research Summary Framing is critical for leaders who must build support for strategic renewal. While research has concentrated on renewal that replaces one set of capabilities with another, we explore a distinctive challenge: how leaders persuade stakeholders to endorse the reprioritization of resources toward a capability set that must ...
Ryan Raffaelli +3 more
wiley +1 more source
Inferring Synergistic and Antagonistic Interactions in Mixtures of Exposures [PDF]
arXiv, 2022 There is abundant interest in assessing the joint effects of multiple exposures on human health. This is often referred to as the mixtures problem in environmental epidemiology and toxicology. Classically, studies have examined the adverse health effects of different chemicals one at a time, but there is concern that certain chemicals may act together ...
arxiv