Results 201 to 210 of about 560,117 (294)

Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists.

Journal of Medicinal Chemistry, 1975
A series of new narcotic antagonists has been synthesized by modifying the C-6 carbonyl group in naloxone (Ia) and naltrexone (Ib). New functional units were introduced by reaction with various phosphorus and sulfur ylides and alkyllithium reagents.
E. Hahn, J. Fishman, R. Heilman
semanticscholar   +4 more sources

Discriminative properties of narcotic antagonists.

Psychopharmacology communications, 1976
There have been many recent reports characterizing the discriminative properties of morphine and related narcotic analgesics in a variety of experimental paradigms, predominantly in the rat (see preceding chapter). It is becoming increasingly evident that a strong association exists between the discriminative properties of these drugs in animals and ...
S. Holtzman, H. Shannon, G. J. Schaefer
semanticscholar   +4 more sources

Aftercare on narcotic antagonists: prospects and problems.

International Journal of the Addictions, 1976
This study examines the problems and prospects of aftercare of the multiple treatment failure opiate addict who is being treated with narcotic antagonists (primarily naltrexone). At the time of this paper, 21 patients had been admitted to the Drug Addiction Research Project at McLean Hospital, with a retention rate of 42%. "Completers," "noncompleters,"
M. Rawlins, M. Randall
semanticscholar   +4 more sources

DISPOSITION OF NARCOTICS AND NARCOTIC ANTAGONISTS *

Annals of the New York Academy of Sciences, 1976
C. Inturrisi
semanticscholar   +4 more sources

Narcotic Antagonists as Analgesics

Science, 1962
2-Dimethylallyl-5,9-dimethyl-2′-hydroxybenzomorphan (Win 20,228) was found to be a weak antagonist of morphine and meperidine, whereas 2-allyl-5-ethyl-2′-hydroxy-9-methyl-6,7-benzomorphan (Win 19,362) and 2-allyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan (Win 19,631) were about three times as potent as nalorphine.
Jane Telford, J. G. Bird, Anne K. Pierson, Louis S. Harris, Sydney Archer, Noel F. Albertson, Arthur S. Keats, C. N. Papadopoulos   +7 more
openaire   +3 more sources

Use of narcotic antagonists to modify stereotypic self-licking, self-chewing, and scratching behavior in dogs.

Journal of the American Veterinary Medical Association, 1988
We evaluated 2 narcotic antagonists, naltrexone and nalmefene, for treatment of refractory self-licking, self-chewing, and scratching behavior in dogs. Eleven dogs with various irritative or pruritic disorders were medicated with naltrexone (1 mg/kg of ...
N. Dodman, Louis Shuster, Stephen D. White, Michael H. Court, Denise Parker, Ross Dixon   +5 more
semanticscholar   +1 more source

Investigation into the use of narcotic antagonists in the treatment of a stereotypic behavior pattern (crib-biting) in the horse.

American Journal of Veterinary Research, 1987
Crib-biting in horses is a repetitive behavior pattern which may involve the activation of both narcotic receptors and dopamine receptors in the CNS. Crib-biting frequency, determined in 7 nontreated horses under controlled conditions, was usually linear
N. Dodman, Louis Shuster, Michael H. Court, Ross Dixon   +3 more
semanticscholar   +1 more source

COMPARATIVE STUDIES WITH NARCOTICS AND NARCOTIC ANTAGONISTS IN MAN

Acta Anaesthesiologica Scandinavica, 1964
ZUSAMMENFASSUNGBei 240 oberflächlich anaesthesierten Patienten, die keine Narkotika als Prämedikation erhalten hatten, wurden die Wirkungen auf Atmung und Kreislauf der folgenden Mittel, allein oder in verschiedenen Kombinationen verabreicht, untersucht: Morphin (0,2 oder 0,3 mg/kg), Oxymorphon(20 μ/kg),Levorphan (50μ/kg),Meperidin (1,5 und 2,0 mg/kg ...
T. A. G. Torda, Francis F. Foldes
openaire   +3 more sources

EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES*

Annals of the New York Academy of Sciences, 1976
Multiple and single drug interactions were studied in morphine-dependent monkeys whose dependency was maintained by self-infusion. Naloxone, naltrexone, and cyclazocine precipitated abstinence syndrome which the animals generally controlled with increased morphine intake.
C. A. Robinson, M. J. Brocco, K. F. Killam   +2 more
openaire   +3 more sources

Clinical Principles for the Narcotic Antagonists

Postgraduate Medicine, 1957
(1957). Clinical Principles for the Narcotic Antagonists. Postgraduate Medicine: Vol. 22, No. 6, pp. 566-571.
Max S. Sadove, M. J. Schiffrin
openaire   +3 more sources