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GnRH Peptide Antagonist: Comparative Analysis of Chemistry and Formulation with Implications for Clinical Safety and Efficacy. [PDF]
Patel S, Saxena B, Mehta P, Niazi SK.
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Defining Discontinuation for Buprenorphine Treatment: Implications for Quality Measurement. [PDF]
Williams AR+6 more
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Treatment Approaches for Opioid Use Disorder Offered in US Substance Use Treatment Facilities.
Park TW+4 more
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Trends in Naloxone Dispensing From Retail Pharmacies in the US.
Rikard SM+3 more
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Studies on the Specificity of Narcotic Antagonists [PDF]
Experiments with five narcotics, (morphine 0.3 mg./kg., oxymorphone 20 μg./kg., levorphan 50 μg./kg., meperidine 1.5 μg./kg. and fentanyl 1.5 μ./kg.) and three narcotic antagonists (nalorphine 150 μg./kg., naloxone 5 μg./kg., and levallorphan 20 μg./kg.
Hans P. Shiffman+4 more
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CLINICAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS*
Annals of the New York Academy of Sciences, 1978Both naloxone and naltrexone are effective narcotic antagonists with minimal agonistic effects and a wide margin of safety. Naloxone is useful in the treatment of narcotic overdose and it is helpful in the quantification of physical dependence. Naltrexone is pharmacologically successful as an orally effective, long-acting antagonist but its clinical ...
Joseph W. Ternes+3 more
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Journal of Medicinal Chemistry, 1975
A series of new narcotic antagonists has been synthesized by modifying the C-6 carbonyl group in naloxone (Ia) and naltrexone (Ib). New functional units were introduced by reaction with various phosphorus and sulfur ylides and alkyllithium reagents.
Hahn Ef, Fishman J, Heilman Rd
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A series of new narcotic antagonists has been synthesized by modifying the C-6 carbonyl group in naloxone (Ia) and naltrexone (Ib). New functional units were introduced by reaction with various phosphorus and sulfur ylides and alkyllithium reagents.
Hahn Ef, Fishman J, Heilman Rd
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Discriminative Properties of Narcotic Antagonists
Psychopharmacology communications, 1977There have been many recent reports characterizing the discriminative properties of morphine and related narcotic analgesics in a variety of experimental paradigms, predominantly in the rat (see preceding chapter). It is becoming increasingly evident that a strong association exists between the discriminative properties of these drugs in animals and ...
Stephen G. Holtzman+2 more
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NARCOTIC–NARCOTIC ANTAGONIST MIXTURES [PDF]
Jane Telford, Arthur S. Keats
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Aftercare on Narcotic Antagonists: Prospects and Problems
International Journal of the Addictions, 1976This study examines the problems and prospects of aftercare of the multiple treatment failure opiate addict who is being treated with narcotic antagonists (primarily naltrexone). At the time of this paper, 21 patients had been admitted to the Drug Addiction Research Project at McLean Hospital, with a retention rate of 42%. "Completers," "noncompleters,"
Maxine Rawlins+4 more
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