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The Combined Use of Narcotics and Narcotic Antagonists for Premedication [PDF]

Anesthesiology, 1959
Francis F. Foldes, Henry M. Brunn, Ludwig R. Koukal, Pearl G. McNall   +3 more
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Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence.

Journal of Medicinal Chemistry, 1975
The pKa's, partition coefficients, and drug distribution coefficients (apparent partition coefficients) have been investigated for a number of narcotics and, where possible, for their congener narcotic antagonists.
J. J. Kaufman, N. Semo, W. S. Koski
semanticscholar   +1 more source

Narcotic Antagonists as Analgesics

Science, 1962
2-Dimethylallyl-5,9-dimethyl-2′-hydroxybenzomorphan (Win 20,228) was found to be a weak antagonist of morphine and meperidine, whereas 2-allyl-5-ethyl-2′-hydroxy-9-methyl-6,7-benzomorphan (Win 19,362) and 2-allyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan (Win 19,631) were about three times as potent as nalorphine.
Jane Telford, J. G. Bird, Anne K. Pierson, Louis S. Harris, Sydney Archer, Noel F. Albertson, Arthur S. Keats, C. N. Papadopoulos   +7 more
openaire   +3 more sources

Use of narcotic antagonists to modify stereotypic self-licking, self-chewing, and scratching behavior in dogs.

Journal of the American Veterinary Medical Association, 1988
We evaluated 2 narcotic antagonists, naltrexone and nalmefene, for treatment of refractory self-licking, self-chewing, and scratching behavior in dogs. Eleven dogs with various irritative or pruritic disorders were medicated with naltrexone (1 mg/kg of ...
N. Dodman, Louis Shuster, Stephen D. White, Michael H. Court, Denise Parker, Ross Dixon   +5 more
semanticscholar   +1 more source

A Research Evaluation OF THE RATIO OF NARCOTIC TO NARCOTIC ANTAGONIST

Anesthesia & Analgesia, 1958
Phillip S. Marcus, Chester W. White, Robert Megirian   +2 more
  +5 more sources

Investigation into the use of narcotic antagonists in the treatment of a stereotypic behavior pattern (crib-biting) in the horse.

American Journal of Veterinary Research, 1987
Crib-biting in horses is a repetitive behavior pattern which may involve the activation of both narcotic receptors and dopamine receptors in the CNS. Crib-biting frequency, determined in 7 nontreated horses under controlled conditions, was usually linear
N. Dodman, Louis Shuster, Michael H. Court, Ross Dixon   +3 more
semanticscholar   +1 more source

Inhibition of ADH release in the rat by narcotic antagonists.

Neuroendocrinology, 1975
The diuretic action of two new narcotic antagonists, oxilorphan and butorphanol, was studied in rats heterozygous for hereditary hypothalmic diabetes insipidus.
M. Miller
semanticscholar   +1 more source

COMPARATIVE STUDIES WITH NARCOTICS AND NARCOTIC ANTAGONISTS IN MAN

Acta Anaesthesiologica Scandinavica, 1964
ZUSAMMENFASSUNGBei 240 oberflächlich anaesthesierten Patienten, die keine Narkotika als Prämedikation erhalten hatten, wurden die Wirkungen auf Atmung und Kreislauf der folgenden Mittel, allein oder in verschiedenen Kombinationen verabreicht, untersucht: Morphin (0,2 oder 0,3 mg/kg), Oxymorphon(20 μ/kg),Levorphan (50μ/kg),Meperidin (1,5 und 2,0 mg/kg ...
T. A. G. Torda, Francis F. Foldes
openaire   +3 more sources

EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES*

Annals of the New York Academy of Sciences, 1976
Multiple and single drug interactions were studied in morphine-dependent monkeys whose dependency was maintained by self-infusion. Naloxone, naltrexone, and cyclazocine precipitated abstinence syndrome which the animals generally controlled with increased morphine intake.
C. A. Robinson, M. J. Brocco, K. F. Killam   +2 more
openaire   +3 more sources

(2-exo-3-endo)-2-Aryltropane-3-carboxylic esters, a new class of narcotic antagonists.

Journal of Medicinal Chemistry, 1978
Tropanes 4 bearing an exo aromatic group on carbon-2, an endo-carbomethoxy group on carbon-3, and either a methyl group or a hydrogen on the nitrogen were found to be narcotic antagonists which were devoid of demonstrable analgesic activity. The activity
R. L. Clarke, A. Gambino, A. Pierson, S. Daum   +3 more
semanticscholar   +1 more source