Results 231 to 240 of about 554,314 (294)

A sustained release depot for narcotic antagonists.

Archives of General Psychiatry, 1974
A total of 175 mg of naltrexone monohydrate, suspended in small particles of a polylactide plastic (500 mg), was injected intramuscularly in dogs whose spinal cords had been transected at the T5-10 levels.
W. Martin, V. Sandquist
semanticscholar   +1 more source

Clinical evaluation of naltrexone treatment of opiate-dependent individuals. Report of the National Research Council Committee on Clinical Evaluation of Narcotic Antagonists.

Archives of General Psychiatry, 1978
A multiclinic controlled trial of naltrexone in opiate-dependent persons led to these conclusions: (1) a narcotic antagonist is an acceptable treatment for a small number of patients undergoing treatment for opiate dependence; (2) the group most likely ...

semanticscholar   +1 more source

Clinical Principles for the Narcotic Antagonists

Postgraduate Medicine, 1957
(1957). Clinical Principles for the Narcotic Antagonists. Postgraduate Medicine: Vol. 22, No. 6, pp. 566-571.
Max S. Sadove, M. J. Schiffrin
openaire   +3 more sources

STRUCTURAL FEATURES ASSOCIATED WITH NARCOTICS AND NARCOTIC ANTAGONISTS

Neuropharmacology, 1975
Viminol shares many pharmacological properties of the traditional narcotics, but it differs from the latter because it has an extremely reduced capacity for producing physical dependence. This chapter discusses the types of pharmacological activity related to the structural features of the Viminol stereoisomers.
openaire   +3 more sources

Narcotic antagonists. Synthesis and evaluation of some subsituted 1,2,3,4,5,6-hexahydro-1,4:2,6-dimethano-3-benzazocines.

Journal of Medicinal Chemistry, 1977
A seres of (+/-)-N-substituted 6-ethyl-or -methyl-8-hydroxy-1,2,3,4,5,6-hexahydro-1,4:2,6-dimethano-3-benzazocines has been prepared from 6 hydroxytropinone.
T. A. Montzka, J. Matiskella
semanticscholar   +1 more source

5-allyl-9-oxobenzomorphans. 3. Potent narcotic antagonists and analgesics-antagonists in the series of substituted 2',9beta-dihydroxy-6,7-benzomorphans.

Journal of Medicinal Chemistry, 1977
5-Allyl-2'-methoxy-2-methyl-9-oxo-6,7-benzomorphan methiodide (1) has been converted in a selective two-step process to the corresponding 9beta-hydroxy intermediates 4 and 6, which in turn were transformed via modified von Braun demethylation-acylation ...
M. Saucier, J. Daris, Y. Lambert, Monkovié, A. Pircio   +4 more
semanticscholar   +1 more source

Clinical aspects of the use of narcotic antagonists: the state of the art.

International Journal of the Addictions, 1977
The clinical application of narcotic antagonists would theoretically be of value to several major groups of users. However, while it is clear that supportive services are needed, these services have not been defined by controlled studies.
H. Kleber
semanticscholar   +1 more source

Narcotic Antagonists: A Reasonable Method of Treating Narcotic Dependency

International Journal of the Addictions, 1975
Historically, narcotic dependence has been treated primarily by substituting one narcotic drug for another. One alternative chemical treatment for narcotic dependency is through the use of a narcotic antagonist. The present study involves the observed side effects and outcome results of treating 40 male heroin addicts with the narcotic antagonist ...
Kenneth G. Schooff, Ronald G. Hersch, John Keegan   +2 more
openaire   +3 more sources

On the ability of narcotic antagonists to produce the narcotic cue.

The Journal of Pharmacology and Experimental Therapeutics, 1976
The ability of narcotic antagonists to produce the narcotic cue was investigated in rats trained to discriminate fentanyl (0.04 mg/kg) from solvent. The partial antagonists pentazocine, cyclazocine and nalorphine were found to possess narcotic cuing activity whereas naloxone lacked any such action at doses up to 160 mg/kg.
F C, Colpaert, C J, Niemegeers, P A, Janssen   +2 more
openaire   +2 more sources

Analgesic narcotic antagonists. 2. 8-Alkymorphinan-6-ones.

Journal of Medicinal Chemistry, 1980
A series of 8-alkyl-3-methoxy-17-methylmorphinan-6-ones (3C) and -isomorphinan-6-ones (3T) were prepared by conjugate addition of lithium dialkylcuprates to the corresponding 7,8-didehydro-6-ones 2C and 2T.
J. Polazzi, R. Schut, M. Kotick, J. Howes, P. Osgood, R. Razdan, J. Villarreal   +6 more
semanticscholar   +1 more source