Results 41 to 50 of about 109,486 (191)

Prescribed pharmaceutical alternatives initiative coinciding with reductions in unregulated street opioid use among young people who use drugs: An interrupted time series analysis

Addiction, EarlyView.
Abstract Background and aims In British Columbia, Canada, an initiative was implemented in 2020 to reduce overdose mortality by prescribing pharmaceutical opioids (primarily hydromorphone) as a substitute for the toxic unregulated drug supply. This study estimated changes in the level and trend of unregulated opioid use and non‐prescribed hydromorphone
Erica McAdam, Mohammad Karamouzian, Michael John Milloy, Carmen Verdicchio, Eric C. Sayre, Kanna Hayashi, Thomas Kerr, Kora DeBeck   +7 more
wiley   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Protective effects of extracellular vesicle‐like nanoparticles derived from Cannabis sativa adventitious roots against UVB‐induced damage in human keratinocytes

International Journal of Cosmetic Science, EarlyView.
Cannabis sativa root‐derived extracellular vesicle‐like nanoparticles (CA‐NPs) were isolated from adventitious root cultures and subjected to physicochemical characterization. Upon UVB exposure, keratinocytes exhibited increased ROS generation, apoptosis and MAPK activation, leading to oxidative stress and skin damage.
Dong Ho Bak, Su Hyun Park, Young Bae Ryu, Cha Young Kim, Jae Cheol Jeong, Woo Sik Kim   +5 more
wiley   +1 more source

Equity–Equality Tensions in Police Social Media Communication With Socially Disadvantaged Neighbourhoods: The Case of Instagram

Information Systems Journal, EarlyView.
ABSTRACT This study draws on Instagram‐related data to examine how and why the equity and equality principles of fairness govern police communication with socially disadvantaged neighbourhoods on social media. Using the computationally intensive theory construction methodology and drawing on institutional theory and the framework for the interplay of ...
Nataliya Berbyuk Lindström, Hamid Khobzi, Ofir Turel   +2 more
wiley   +1 more source

Negotiated Ventilation: Conceptualising Interprofessional Decision Work in Intensive Care—An Ethnographic Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To conceptualise how ventilation‐related decisions are accomplished as interprofessional work in intensive care practice, moving beyond approaches that treat decision‐making as discrete events. Design Ethnography. Methods Data were generated through 97 h of participant observation and 17 episodic interviews with nurses (n = 12) and ...
Andreas Küpper, Marcel Schmucker, Laura Hahn, Astrid Elsbernd, Simon Kitto, Cornelia Mahler   +5 more
wiley   +1 more source

Polizieren, Sexualität und Gender - Feminismus zwischen Machtkritik und Punitivität

, 2021
Governing the narcotic city. Imaginaries, practices and discourses of public drug in European citiesGoverning the narcotic city. Imaginaries, practices and discourses of public drug in European cities (HERA Public Spaces: Culture and Integration in ...
Künkel, Jenny
core  

Optimising Asparaginase Use and Managing Hypersensitivity in Australasia—A Clinical Practice Guideline From the Australian and New Zealand Children's Haematology/Oncology Group

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Asparaginase is a critical component of modern multi‐agent chemotherapy regimens for paediatric acute lymphoblastic leukaemia and lymphoblastic lymphoma, with inadequate exposure leading to inferior patient outcomes. Objectives To develop a clinical practice guideline for the use of asparaginase products in the Australasian context.
Matthew J. O'Connor, Michelle Martin, Sarah M. Trinder, Draga Barbaric, Diane Hanna, Chow Y. Lai, Michael P. Osborn, Tim Prestige, Bryony Ross, Leanne Super, Thomas Walwyn, Stacie S. Wang, Andrew Wood, Andrew S. Moore, Rishi S. Kotecha, Siobhan Cross   +15 more
wiley   +1 more source

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo [PDF]

, 2012
We have previously shown that peroxisome proliferator activating receptor ß/d (PPAR ß/d is overexpressed in psoriasis. PPAR ß/d is not present in adult epidermis of mice.
Kevin D. Read (165019), Palmer Colin, Kally Booth, Katrin Hack, Booth Kally, Colin Palmer (165015), Suzanne Norval, Read, Kevin D, Hack Katrin, John Foerster (165047), Robert Kime, Kevin D Read, John Foerster, Kally Booth (165039), Louise Reilly, Suzanne Norval (165024), Read Kevin D., Palmer, Colin; id_orcid, Norval, Suzanne, Reilly, Louise, Louise Reilly (165006), Reilly Louise, Read, Kevin, Palmer, Colin, Hack, Katrin, Robert Kime (165030), Colin Palmer, Kime Robert, Foerster John, Foerster, John, Katrin Hack (165002), Kime, Robert, Norval Suzanne, Booth, Kally   +33 more
core   +1 more source

Planned Approach and Implementation of Pharmacology Teaching in the Bachelor's Veterinary Nursing Programme in Sweden

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Veterinary Nurses play a key role in handling drugs and perform medication treatments, thus pharmacological knowledge is essential. The veterinary nurses' role varies widely worldwide but does not include the prescription of drugs. Nevertheless, pharmacology is a complex subject within veterinary nursing education and for the registered ...
Lena Olsén, Ann‐Christin Blomkvist
wiley   +1 more source

Impact of Novel Tools for Blended and Competency‐Based Learning in Veterinary Compounding and Prescribing

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT According to the European Association of Establishments for Veterinary Education (EAEVE), a graduate of veterinary medicine should be able to prescribe and dispense “medicines correctly and responsibly in accordance with legislation and latest guidance” (2019). In Germany, veterinarians can dispense drugs from their in‐practice pharmacy, which
Sonja Bröer, Viviane Filor, Wolfgang Bäumer   +2 more
wiley   +1 more source