Results 31 to 40 of about 109,486 (191)

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu   +15 more
wiley   +1 more source

Method of Administering Narcotic Antagonists and Analgesics and Novel Dosage Forms Containing Same [PDF]

open access: yes, 1984
The invention provides a novel method of administering narcotic antagonists, narcotic analgesics and related compounds, and novel dosage forms containing those compounds which are adapted for nasal administration. The nasal dosage forms disclosed include
Hussain, Anwar A.
core  

Application of electronic prescriptions for narcotic drugs in quality control [PDF]

open access: yes, 2022
Objective To investigate the significance of electronic prescriptions on the management of narcotic drugs, so as to constantly optimize the management of narcotic drugs.
BAI Bing, YANG Gen-zhi, ZHANG Yue-lun, TIAN Yuan, SHEN Le, HUANG Yu-guang
core   +1 more source

The Hidden Costs of Coffee Production in the Eastern African Value Chains

open access: yesSustainable Development, EarlyView.
ABSTRACT There is increasing recognition that significant hidden costs associated with agrifood systems are not reflected in market prices. Coffee is among the three most traded agricultural commodities in the world and supports the livelihoods of more than 30 million smallholder households.
Annet Adong   +3 more
wiley   +1 more source

Exposure to Structurally Related Organophosphate Esters Elicits Distinct Metabolomic Perturbations in Daphnia magna

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Organophosphate esters (OPEs) are found ubiquitously in the environment and exposure to these chemicals has induced behavioral, developmental, and morphological impairments in several model organisms. Yet there is still a lack of understanding of how sub‐lethal exposure disrupts organism function at the molecular‐level, especially for Daphnia ...
Salwa Hajir   +4 more
wiley   +1 more source

Masculinity, Prostitution, and the Imaginary Northwest in Chinese Travel Writings About Shanxi and Western Inner Mongolia, 1920–1949

open access: yesGender &History, EarlyView.
ABSTRACT This article considers travel writings by metropolitan men in Republican China about Shanxi and western Inner Mongolia as a case study to further explore the transformations and continuities of Chinese masculinities. Drawing upon a range of popular travel narratives, it shows that so‐called “Worn‐Out Shoes (poxie)” – women perceived as ...
Amanda Zhang
wiley   +1 more source

Apprehending narcotic smugglers in Malta [PDF]

open access: yes, 1992
This is an account of the experience of the radiological department in identifying heroin smugglers coming from the African continent in transit through Malta.
Zammit, Anthony
core  

New Potential Uroselective NO-Donor α1-Antagonists

open access: yes, 2016
A recent uroselective α1-adrenoceptor antagonist, REC15/2739, has been joined with nitrooxy and furoxan NO-donor moieties to give new NO-donor α1-antagonists.
Gianni Motta (2740474)   +7 more
core   +1 more source

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists

open access: yes, 2023
Herein, we report the optimization of a meta-substituted series of selective estrogen receptor degrader (SERD) antagonists for the treatment of ER+ breast cancer.
Darren Stead (2178408)   +42 more
core   +2 more sources

Barriers and facilitators to detoxification from opioid substitution treatment: A mixed‐methods systematic review

open access: yesAddiction, EarlyView.
Abstract Background and aims Despite the well‐documented benefits of opioid substitution treatment (OST) in treating opioid dependence (OD), many people diagnosed with OD desire to live a drug‐free life. The transition to abstinence involves detoxification: a gradual dose reduction of OST to zero milligrams.
Amy Bagshaw   +5 more
wiley   +1 more source

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