Results 21 to 30 of about 132,140 (136)

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Ultrasound‐Guided Fasciotomy for Chronic Exertional Compartment Syndrome: A Case Report With Long‐Term Sonographic Outcomes

Journal of Clinical Ultrasound, EarlyView.
First report of the long‐term sonographic appearance after ultrasound‐guided fasciotomy for chronic exertional compartment syndrome. Six‐month ultrasound demonstrated persistent fascial separation associated with excellent clinical outcomes. ABSTRACT We report the case of a 38‐year‐old recreational female runner with anterior and lateral chronic ...
Alexandre Lavigne, Brennan J. Boettcher, Michael Khadavi   +2 more
wiley   +1 more source

Comparative analysis of virtual screening approaches in the search for novel EphA2 receptor antagonists [PDF]

, 2015
The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth.
PALA, Daniele, Callegari, Donatella, Scalvini, Laura, Mor, Marco, Lodola, Alessio, Donatella Callegari, Pala, Daniela, Incerti, Matteo, Rivara, Silvia, Daniele Pala, Tognolini, Massimiliano, Marco Mor, Massimiliano Tognolini, Laura Scalvini, Matteo Incerti, Silvia Rivara, Alessio Lodola   +16 more
core   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Opioid antagonists for smoking cessation

, 2006
Background: The reinforcing properties of nicotine may be mediated through release of various neurotransmitters both centrally and systemically. People who smoke report positive effects such as pleasure, arousal, and relaxation as well as relief of ...
Lindsay F Stead, A. Eden Evins, Kate Cahill, Sean P. David, Tim Lancaster   +4 more
core   +1 more source

Regenerative Peripheral Nerve Interface (RPNI) Surgery for Naturalistic Prosthetic Control

Muscle &Nerve, EarlyView.
ABSTRACT Loss of limb function remains a significant public health challenge affecting millions of people worldwide, causing high rates of disability, unemployment, and chronic pain. Current neuroprosthetic devices are limited by unintuitive control and poor long‐term embodiment.
Ahneesh J. Mohanty, Yucheng Tian, Theodore A. Kung, Cynthia A. Chestek, Alex K. Vaskov, Deanna H. Gates, Alison K. Snyder‐Warwick, Paul S. Cederna   +7 more
wiley   +1 more source

Exposure to Structurally Related Organophosphate Esters Elicits Distinct Metabolomic Perturbations in Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Organophosphate esters (OPEs) are found ubiquitously in the environment and exposure to these chemicals has induced behavioral, developmental, and morphological impairments in several model organisms. Yet there is still a lack of understanding of how sub‐lethal exposure disrupts organism function at the molecular‐level, especially for Daphnia ...
Salwa Hajir, Sanam Yousifie, Karl J. Jobst, André J. Simpson, Myrna J. Simpson   +4 more
wiley   +1 more source

A picture worth a thousand words: The effect of murals on crime

Criminology &Public Policy, EarlyView.
Abstract Research Summary Drawing on the tenets of situational crime prevention, several place‐based interventions are both effective in reducing crime and relatively inexpensive. The installation of large exterior murals also fits within the situational crime prevention framework.
Maya Moritz
wiley   +1 more source

Interactions of narcotic antagonists and antagonist-analgesics

, 1968
In the rat the potent narcotic antagonist N-cyclopropylmethyl-6,14-endoethano-7α- (1-hydroxy-1-methylethyl)-tetrahydronororipavine (M5050, Reckitt), which itself lacks analgesic activity, resembled naloxone in its capacity to reverse the antinociceptive ...
D Dugdall, G F Blane
core   +1 more source

Prescribed pharmaceutical alternatives initiative coinciding with reductions in unregulated street opioid use among young people who use drugs: An interrupted time series analysis

Addiction, EarlyView.
Abstract Background and aims In British Columbia, Canada, an initiative was implemented in 2020 to reduce overdose mortality by prescribing pharmaceutical opioids (primarily hydromorphone) as a substitute for the toxic unregulated drug supply. This study estimated changes in the level and trend of unregulated opioid use and non‐prescribed hydromorphone
Erica McAdam, Mohammad Karamouzian, Michael John Milloy, Carmen Verdicchio, Eric C. Sayre, Kanna Hayashi, Thomas Kerr, Kora DeBeck   +7 more
wiley   +1 more source