Results 41 to 50 of about 3,781,173 (328)
THE EFFECT OF NARCOTIC AND NARCOTIC-ANTAGONIST DRUGS IN THE NEWBORN RABBIT
British Journal of Anaesthesia, 1976 The newborn rabbit responds to acute anoxia, as a result of breathing nitrogen, with successive periods of dyspnoea, primary apnoea, gasping and terminal apnoea. Pethidine caused an increase in the period of primary apnoea and a decrease in the duration and rate of gasping.
G. W Stephen, L. V Cooper, D Harvey
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Chemistry &Biodiversity, EarlyView.Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper +6 more
wiley +1 more source
Brain Sciences, 2020 New/novel psychoactive substances (NPS) are defined as new narcotic/psychotropic drugs which are not controlled by the United Nations’ 1961 Narcotic Drugs/1971 Psychotropic Substances conventions, but which may pose a public health threat [...]
Fabrizio Schifano
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Clinical Pharmacology &Therapeutics, EarlyView.Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik +7 more
wiley +1 more source
Gut microbes–spinal connection is required for itch sensation
Gut MicrobesThe gut microbiota has been linked to a number of neurological disorders. However, it is unclear whether the gut microbiota is involved in the genesis of chronic itch, a refractory condition that afflicts patients both physically and mentally.
Tong Jin +13 more
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Journal of Pharmacoeconomics and Pharmaceutical Management, 2023 Background: Narcotic drugs are used as an effective analgesic in diseases such as cancers and malignancies after surgery and addiction treatment. The available data show that the burden of addiction in Iranian society is not decreasing despite several ...
Hossein Rastegar +2 more
doaj
Identification of Tetrahydrocannabidiol Metabolites in Human Urine
Drug Testing and Analysis, EarlyView.The detection of Phase I and II metabolites of tetrahydrocannabidiol (H4CBD) in urine after oral ingestion of 25‐mg H4CBD by a volunteer is described. The proposed metabolite structures are based on ESI+ spectra recorded by HPLC‐HRMS and EI spectra after trimethylsilylation recorded by GC–MS.
Willi Schirmer +3 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Throughout 2014–2023, over 20,000 AAS analyses have been conducted at the drug of abuse laboratory, Karolinska University Hospital. Approximately 20% and 2% of the samples have been positive for AAS, with no trends of increase or decrease. Around 50% of the AAS‐positive samples were also positive for narcotics (year 2022–2023), with gender differences;
Kim Petterson Bohlin +4 more
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Infant Mental Health Journal: Infancy and Early Childhood, EarlyView.Abstract Maternal substance use is a pressing public health issue that confers risk for maternal health, the parent‐infant relationship, and child development. Integrated interventions that jointly address maternal substance use and child development have shown promise for enhancing child outcomes.
Sophie Barriault +6 more
wiley +1 more source
Pharmacological ResearchAberrant energy metabolism in the brain is a common pathological feature in the preclinical Alzheimer's Disease (AD). Recent studies have reported the early elevations of glycolysis-involved enzymes in AD brain and cerebrospinal fluid according to a ...
Xiu Yang +7 more
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