Results 41 to 50 of about 25,223 (258)

Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

open access: yesNeurobiology of Stress, 2022
Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji   +6 more
doaj  

Narcotic Drugs and Crime

open access: yesJournal of the American Institute of Criminal Law and Criminology, 1921
With prohibition in full force it was expected that many would seek other outlet for vice, and naturally the one most prominent, and which was considered next in importance was that of narcotic drug addiction. This problem has been a source of worry to the medical and legal profession as well as the social workers and investigators for many years, but ...
openaire   +2 more sources

Toward a Cannabis Terroir: Untargeted Metabolomic Profiling of Authentic Samples Using Gas Chromatography–High‐Resolution Mass Spectrometry (GC‐HRMS) and Liquid Chromatography–High‐Resolution Tandem Mass Spectrometry (LC‐HRMS/MS)

open access: yesDrug Testing and Analysis, EarlyView.
This study developed a comprehensive metabolomics workflow using GC‐HRMS and LC‐HRMS/MS and analyzed 35 CBD‐type cannabis flowers grown under varying conditions. Key discriminative compounds enabled classification by chemical phenotype and cultivation environment. The results showed that environmental factors influence chemical profiles, supporting the
Sandra N. Poetzsch   +3 more
wiley   +1 more source

Post‐Thyroidectomy Opioid Prescription and Risk of Persistent Opioid Use: A Propensity Matched Cohort Study

open access: yesHead &Neck, EarlyView.
ABSTRACT Background This study evaluates the risk of persistent opioid use (POU) among thyroidectomy patients given postoperative opioids. Methods Patients undergoing thyroidectomy were identified using the TriNetX Research Platform (2010–2024). Cohorts were divided based on opioid prescriptions on the day of surgery.
Oluwatobiloba Ayo‐Ajibola   +4 more
wiley   +1 more source

Effects of integrated programs for substance‐involved mothers on infant and child development outcomes: A systematic review and meta‐analysis

open access: yesInfant Mental Health Journal: Infancy and Early Childhood, EarlyView.
Abstract Maternal substance use is a pressing public health issue that confers risk for maternal health, the parent‐infant relationship, and child development. Integrated interventions that jointly address maternal substance use and child development have shown promise for enhancing child outcomes.
Sophie Barriault   +6 more
wiley   +1 more source

Protocol to study projection-specific circuits in the basal ganglia of adult mice using viral vector tracing, optogenetics, and patch-clamp technique

open access: yesSTAR Protocols, 2023
Summary: Analysis of synaptic strength and plasticity provides functional insights of complicated neural circuits. Here, we describe steps for cell- and projection-specific optogenetic manipulation of divergent basal ganglia circuits using anterograde ...
Ya-Wei Ji   +4 more
doaj  

Unemployed Black/African Americans With Disabilities’ Treatment Acquisition for Substance Use Disorder and Serious Mental Illness

open access: yesJournal of Multicultural Counseling and Development, EarlyView.
ABSTRACT Black/African Americans with disabilities who live with substance use disorder and/or serious mental illness are an underserved population in mental health treatment. We conducted a quantitative analysis using the 2022 National Survey on Drug Use and Health (N = 317) to identify treatment trends and interpreted results using DisCrit and the ...
Jennifer M. Cook   +4 more
wiley   +1 more source

Immediate postoperative anesthesia with either lidocaine or bupivacaine: A short‐term clinical response

open access: yesJournal of Periodontology, EarlyView.
Abstract Background The purpose of this randomized, three‐armed clinical trial is to determine if a postoperative injection of 0.5% bupivacaine is more effective than 2% lidocaine in controlling pain after periodontal flap surgery. Methods Seventy‐six patients planned for similar periodontal surgeries were included.
Jessica D. Koster   +4 more
wiley   +1 more source

Risk of colorectal cancer and cancer‐related mortality in type 2 diabetes patients treated with metformin, SGLT‐2 inhibitors, or their combination

open access: yes
Cancer Communications, EarlyView.
Xianhua Mao   +11 more
wiley   +1 more source

Polymer type effect on microparticle blend of ethyl cellulose, poly(lactic‐co‐glycolic acid) and poly(ε‐caprolactone) for controlled drug delivery with varying solubility

open access: yesPolymer International, EarlyView.
Preparation, possible microparticles formed, morphology of microparticles and drug release profile from polymeric microparticles. Abstract The objective of this study was to investigate the impact of polymer type on polymeric microparticle blends designed for controlled drug delivery. Microparticle blends containing a single drug (propranolol HCl [Pro]
Muhaimin Muhaimin, Roland Bodmeier
wiley   +1 more source

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