Results 21 to 30 of about 24,515 (215)

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Low back pain is the leading cause of disability worldwide and one of the most common reasons for seeking healthcare. Despite numerous care strategies, patients with low back pain continue to exhibit poor outcomes. Spinal cord stimulation (SCS) is an evidence‐based therapeutic modality for patients with failed back surgery syndrome ...
Jan M. Eckermann, Julie G. Pilitsis, Christopher Vannaboutathong, Belinda J. Wagner, Rose Province‐Azalde, Markus A. Bendel   +5 more
wiley   +1 more source

Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction

Cellular & Molecular Biology Letters
Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses a significant threat to their postoperative quality of life and overall well-being.
Wei-Feng Wu, Chen Chen, Jia-Tao Lin, Xin-Hao Jiao, Wei Dong, Jie Wan, Qiang Liu, Yong-Kang Qiu, Ao Sun, Yi-Qi Liu, Chun-Hui Jin, He Huang, Hui Zheng, Cheng-Hua Zhou, Yu-Qing Wu   +14 more
doaj   +1 more source

Analyzing the Open/Deep Web to Better Understand the New/Novel Psychoactive Substances (NPS) Scenarios: Suggestions from CASSANDRA and NPS.Finder Research Projects

Brain Sciences, 2020
New/novel psychoactive substances (NPS) are defined as new narcotic/psychotropic drugs which are not controlled by the United Nations’ 1961 Narcotic Drugs/1971 Psychotropic Substances conventions, but which may pose a public health threat [...]
Fabrizio Schifano
doaj   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science
Postoperative cognitive dysfunction (POCD) negatively impacts prognosis; however, the underlying mechanisms remain unclear. We demonstrated that tibial fracture surgery led to cognitive dysfunction in 18‐month‐old mice, concomitant with a reduction in ...
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
doaj   +1 more source

Updated ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease 2025

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To revise the 2018 European Reference Network for rare Inherited and Congenital Digestive and Gastrointestinal Anomalies (ERNICA) clinical guideline for the management of rectosigmoid Hirschsprung's disease (HSCR) based on new evidence and evolving clinical priorities, ensuring continued relevance, trustworthiness, and consistency ...
Daniel Rossi, Willemijn Irvine, Anna Löf Granström, Annika Mutanen, Roel Bakx, Kristin Bjørnland, Duccio Cavalieri, Piotr Czauderna, Anne Dariel, Mark Ellebæk, Francesco Fascetti Leon, Fabio Fusaro, Dirk‐Jan Gloudemans, Marietta Jank, Peter Kolja Kvist, Martin Lacher, Annette Lemli, Lucas Matthyssens, Louise Montalva, Pedro Palazon, Alessio Pini Prato, Lucie Pos, Roxana Rassouli‐Kirchmeier, Konrad Reinshagen, Nagoud Schukfeh, Rony Sfeir, Olivia Spivack, Pernilla Stenström, Lovisa Telborn, Eelke Toxopeus, Alejandra Vilanova, Miriam Wilms, Rene Wijnen, Cornelius E. J. Sloots, Mikko Pakarinen, Tomas Wester   +35 more
wiley   +1 more source

GABAB receptor activation contributes to post-surgery cognitive impairments in mice by inducing hippocampal BDNF hypermethylation

Annals of Medicine
Background Clinical observations have shown that brain-derived neurotrophic factor (BDNF) expression is reduced in patients with impaired cognitive function after anaesthesia and surgery. Abnormal epigenetic changes may contribute to this condition.
Tong Wu, Xiao-Yu Sun, Jing Cao, Kun Tong, Jing-Ru Hao, Nan Sun, Can Gao   +6 more
doaj   +1 more source

THE EFFECT OF NARCOTIC AND NARCOTIC-ANTAGONIST DRUGS IN THE NEWBORN RABBIT

British Journal of Anaesthesia, 1976
The newborn rabbit responds to acute anoxia, as a result of breathing nitrogen, with successive periods of dyspnoea, primary apnoea, gasping and terminal apnoea. Pethidine caused an increase in the period of primary apnoea and a decrease in the duration and rate of gasping.
G W, Stephen, L V, Cooper, D, Harvey
openaire   +2 more sources

Preoperative expectations and 2‐year outcomes after primary anterior cruciate ligament reconstruction

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose A growing emphasis on patient‐centered care, paired with a steady rise in anterior cruciate ligament reconstructions (ACLRs), has led to greater interest in identifying predictors of patient‐reported outcomes (PROs) after ACLR. Patient expectations are one factor previously identified as potentially impacting post‐operative PROs in ...
Prateek Swamykumar, Michael A. McCurdy, Dominic J. Ventimiglia, Matthew T. Chrencik, Cameron C. Lingenfelter, Joseph M. Blommer, Natalie L. Leong, Sean J. Meredith, R. Frank Henn III, Jonathan D. Packer   +9 more
wiley   +1 more source

Postoperative Effects of Celecoxib on Opioid Use and Pain Control After Benign Oropharyngeal Surgery

The Laryngoscope, EarlyView.
This study evaluated how the addition of celecoxib to a multimodal pain regimen following tonsillectomy + adenoidectomy, or uvulopalatopharyngoplasty (UPPP) + tonsillectomy affects postoperative opioid use and pain control. Patients who received celecoxib consumed significantly fewer opioids compared to the historic control group, with similar ...
Alana Platukus, Praneet Kaki, Anastasia Kaffenes, Udeerna Tippabhatla, Jared Robinson, Jaehee Kim, Erin Creighton, Meghan Crippen, Maurits Boon, Colin Huntley   +9 more
wiley   +1 more source