Results 11 to 20 of about 24,515 (215)

Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases

Frontiers in Pharmacology, 2022
Cav1.2 plays an essential role in learning and memory, drug addiction, and neuronal development. Intracellular calcium homeostasis is disrupted in neurodegenerative diseases because of abnormal Cav1.2 channel activity and modification of downstream Ca2 ...
Yun Li, Hong Yang, Tianhan He, Liang Zhang, Chao Liu   +4 more
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The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice

Frontiers in Molecular Neuroscience, 2022
The role of the Slack (also known as Slo2.2, KNa1.1, or KCNT1) channel in pain-sensing is still in debate on which kind of pain it regulates. In the present study, we found that the Slack–/– mice exhibited decreased mechanical pain threshold but normal ...
Ye Liu, Ye Liu, Ye Liu, Fang-Fang Zhang, Fang-Fang Zhang, Fang-Fang Zhang, Ying Song, Ying Song, Ying Song, Ran Wang, Ran Wang, Qi Zhang, Qi Zhang, Qi Zhang, Zhong-Shan Shen, Zhong-Shan Shen, Zhong-Shan Shen, Fei-Fei Zhang, Fei-Fei Zhang, Fei-Fei Zhang, Dan-Ya Zhong, Dan-Ya Zhong, Dan-Ya Zhong, Xiao-Hui Wang, Xiao-Hui Wang, Xiao-Hui Wang, Qing Guo, Qing Guo, Qing Guo, Qiong-Yao Tang, Qiong-Yao Tang, Qiong-Yao Tang, Zhe Zhang, Zhe Zhang, Zhe Zhang   +34 more
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Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

Frontiers in Neuroscience, 2021
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle.
Weinan Zhao, Weinan Zhao, Weinan Zhao, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Yu Ma, Yu Ma, Yu Ma, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Bingqian Fan, Bingqian Fan, Bingqian Fan, Xiaojing Zhai, Xiaojing Zhai, Xiaojing Zhai, Mengfan Hu, Mengfan Hu, Mengfan Hu, Mengfan Hu, Qing Wang, Qing Wang, Qing Wang, Qing Wang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Yixue Qin, Yixue Qin, Yixue Qin, Yixue Qin, Sha Sha, Sha Sha, Sha Sha, Sha Sha, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Fan Ye, Yihan Xia, Guangchao Zhang, Guangchao Zhang, Guangchao Zhang, Li Yang, Li Yang, Li Yang, Shiya Zou, Shiya Zou, Shiya Zou, Zheng Xu, Zheng Xu, Zheng Xu, Sunhui Xia, Sunhui Xia, Sunhui Xia, Yumei Yu, Yumei Yu, Yumei Yu, Mannan Abdul, Mannan Abdul, Mannan Abdul, Mannan Abdul, Jun-Xia Yang, Jun-Xia Yang, Jun-Xia Yang, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Fang Zhou, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang   +83 more
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The PrLGlu→avBNSTGABA circuit rapidly modulates depression-like behaviors in male mice

iScience, 2023
Summary: Depression is a global disease with a high prevalence. Here, we examine the role of the circuit from prelimbic mPFC (PrL) to the anterior ventral bed nucleus of the stria terminalis (avBNST) in depression-like mice through behavioral tests ...
Jie-ying Chen, Ke Wu, Miao-miao Guo, Wei Song, Si-ting Huang, Yong-mei Zhang   +5 more
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Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

Neurobiology of Stress, 2022
Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji, Qing-Xiang Meng, Ying Wang, Zi-Ming Zhou, Yu Song, Rong Hua, Yong-Mei Zhang   +6 more
doaj   +1 more source

Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice

Frontiers in Aging Neuroscience, 2022
Recent observation demonstrated that prolonged anesthesia modifies brain synaptic architecture in all ages, including adult. Propofol is the most commonly utilized anesthetics at clinic.
Xiaoxuan Yang, Chen Chen, Chen Chen, Dongmei Qu, Yanping Liu, Yanping Liu, Ning Wang, Ning Wang, Haibi Wang, Haibi Wang, Youjia Fan, Yushan Zhou, Buwei Yu, Qingsheng Xue, Yuqing Wu, Yuqing Wu, Han Lu   +16 more
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The Narcotic Drug Problem

The American Journal of the Medical Sciences, 1920
Mode of access: Internet.
openaire   +2 more sources

Protocol to study projection-specific circuits in the basal ganglia of adult mice using viral vector tracing, optogenetics, and patch-clamp technique

STAR Protocols, 2023
Summary: Analysis of synaptic strength and plasticity provides functional insights of complicated neural circuits. Here, we describe steps for cell- and projection-specific optogenetic manipulation of divergent basal ganglia circuits using anterograde ...
Ya-Wei Ji, Xiang-Ying Xu, Cui Yin, Chunyi Zhou, Cheng Xiao   +4 more
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Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

Cell Death and Disease
Neuroinflammation is a key factor in the pathogenesis of Parkinson’s disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. However, the role of peripheral
Wei Song, Zi-ming Zhou, Le-le Zhang, Hai-feng Shu, Jin-ru Xia, Xia Qin, Rong Hua, Yong-mei Zhang   +7 more
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Validation of International Classification of Diseases Code–Based Case Definitions of Immune Checkpoint Inhibitor–Associated Inflammatory Arthritis From Administrative Health Data

Arthritis &Rheumatology, EarlyView.
Objective Immune checkpoint inhibitors (ICIs) for cancer can lead to immune‐related adverse events, including ICI‐associated inflammatory arthritis (ICI‐IA). There are no validated International Classification of Diseases (ICD) code–based case definitions for ICI‐IA.
Manar Elsayed, Zoe Hsu, Finlay A. McAlister, William D. Leslie, Lisa M. Lix, Sasha Bernatsky, Suzanne N. Morin, Michelle M. Graham, Aurore Fifi‐Mah, Shahin Jamal, Janet Roberts, Carrie Ye   +11 more
wiley   +1 more source