Results 41 to 50 of about 24,515 (215)

Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer’s disease models

Pharmacological Research
Aberrant energy metabolism in the brain is a common pathological feature in the preclinical Alzheimer's Disease (AD). Recent studies have reported the early elevations of glycolysis-involved enzymes in AD brain and cerebrospinal fluid according to a ...
Xiu Yang, Yuan-Hao Chen, Le Liu, Zheng Gu, Yue You, Jing-Ru Hao, Nan Sun, Can Gao   +7 more
doaj   +1 more source

Insights from a six‐year hair drug analysis compendium in drug‐facilitated crimes involving vulnerable population cases

Journal of Forensic Sciences, EarlyView.
Abstract Hair analysis is a well‐established matrix in forensic toxicology, offering a valuable alternative or complement to traditional matrices in diverse contexts, including drug‐facilitated crimes (DFC), elder abuse, and accidental exposure in children.
Amandine Fort, Coralie Boudin, Hélène Eysseric‐Guerin, Virginie Scolan, François Paysant, Cloé Scherpereel, Mélissa Revet, Françoise Stanke‐Labesque, Théo Willeman   +8 more
wiley   +1 more source

RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer’s disease

Acta Neuropathologica Communications
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder among the elderly, with limited effective treatments available in clinical practice.
Miao-Jin Ji, Yun Li, Jiao Yang, Kangjunjie Wang, Shuning Sang, Hong Yang, Chenhao Tian, Xin Tang, Ji-Heng Cai, Tianhan He, Cheng Zhang, Huanyao Tang, Tiantao Cui, Xinran Meng, Xiang Cao, Jiaqi Zhu, Jie Wang, Jun-Li Cao, Daming Gao, Chao Liu   +19 more
doaj   +1 more source

Cell types and neuronal genetic architecture in the rat CSF-contacting nucleus and the role of 5-HT in this nucleus in mediating morphine addiction through the brain–CSF circuit

Frontiers in Neuroscience
IntroductionTo elucidate the cellular composition of the cerebrospinal fluid-contacting nucleus, establish a comprehensive gene expression database for this nucleus, and investigate its potential functional roles.Methodswe used single-cell sequencing ...
Ying Li, Ying Li, Ying Li, Bin Gui, Bin Gui, Bin Gui, Yijun Zhang, Yijun Zhang, Yijun Zhang, Licai Zhang, Licai Zhang, Licai Zhang   +11 more
doaj   +1 more source

Investigation of eosin Y as a colorimetric sensor for the detection of fentanyl hydrochloride and fentanyl freebase

Journal of Forensic Sciences, EarlyView.
Abstract The increasing prevalence of fentanyl within the illegal global drug market underscores the need for rapid, low‐cost, and straightforward detection methods. Eosin Y demonstrates a measurable color change in the presence of fentanyl, making it a promising candidate for colorimetric sensing and preliminary identification of fentanyl ...
Alan J. Zhou, Melissa M. Dixon, Brady S. Gentle, Genevieve H. Dennison, Kellie L. Tuck   +4 more
wiley   +1 more source

Toronto's drug policy paradox: Harm reduction sites and drug police occurrences in Toronto neighborhoods (1992–2020)

Criminology, EarlyView.
Abstract Discourse around drug policy presents a stark contrast between policing and harm reduction models, sparking debates on the state's regulatory versus protective role. Canada is an ideal case to study drug policy models due to its global recognition as a leader in harm reduction alongside continued reliance on policing of drugs.
Taylor Domingos
wiley   +1 more source

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

eLife
Memory impairment in chronic pain patients is substantial and common, and few therapeutic strategies are available. Chronic pain-related memory impairment has susceptible and unsusceptible features.
Mengqiao Cui, Xiaoyuan Pan, Zhijie Fan, Shulin Wu, Ran Ji, Xianlei Wang, Xiangxi Kong, Zhou Wu, Lingzhen Song, Weiyi Song, Jun-Xia Yang, Hongjie Zhang, Hongxing Zhang, Hai-Lei Ding, Jun-Li Cao   +14 more
doaj   +1 more source

Determinants of case outcomes in Rwanda's postgenocide gacaca courts

Criminology, EarlyView.
Abstract Transitional justice trials have become a central mechanism for addressing mass violence and human rights violations, yet little is known about the determinants of case outcomes within these courts—particularly in domestic contexts. This study examines Rwanda's gacaca courts, a localized transitional justice system that tried people suspected ...
Hollie Nyseth Nzitatira, Jared Edgerton, Anneliese Ward   +2 more
wiley   +1 more source

NAT10 inhibition alleviates astrocyte autophagy by impeding ac4C acetylation of Timp1 mRNA in ischemic stroke

Acta Pharmaceutica Sinica B
Although a single nucleotide polymorphism for N-acetyltransferase 10 (NAT10) has been identified in patients with early-onset stroke, the role of NAT10 in ischemic injury and the related underlying mechanisms remains elusive.
Li Yang, Xiaotong Li, Yaxuan Zhao, Hao Chen, Can Wang, Angrong Wu, Xintong Guo, Yue Huang, Qihui Wang, Lingyun Hao, Xiaowen Li, Ying Ji, Jin Ban, Guangtian Wang, Junli Cao, Zhiqiang Pan   +15 more
doaj   +1 more source

FEATURES OF STORAGE AND TRANSPORTATION OF NARCOTIC ANALGESICS IN CONDITIONS OF EMERGENCY SITUATIONS

Фармация и фармакология (Пятигорск), 2015
The article performs the analysis of the current state regulatory-legal framework relating to the use of narcotic analgesics in health care institutions in emergencies peace and wartime.There are developed recommendations for adapting the requirements ...
P. V. Oliynyk, B. P. Hromovyk
doaj   +1 more source