Results 41 to 50 of about 2,438,339 (329)

Implications of nasal delivery of bromelain on its pharmacokinetics, tissue distribution and pharmacodynamic profile-A preclinical study.

PLoS ONE, 2022
Asthma is a polygenic chronic inflammatory respiratory disease devastating the quality of life and state economies. Therefore, utilization of natural products as a therapeutic approach has attained wider consideration for development of novel drugs for ...
Manu Sharma, Namita Gupta, Easha Pandey
doaj   +1 more source

Nano-Spray-Dried Levocetirizine Dihydrochloride with Mucoadhesive Carriers and Cyclodextrins for Nasal Administration

Pharmaceutics, 2023
Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form ...
Mirella Mirankó, Judit Tóth, Csilla Bartos, Rita Ambrus, Tivadar Feczkó   +4 more
doaj   +1 more source

Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]

, 2016
Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana, Kitazawa, Haruki, Villena, Julio Cesar, Zelaya, María Hortensia del Rosario   +3 more
core   +1 more source

Safety and biodistribution of exosomes derived from human induced pluripotent stem cells

Frontiers in Bioengineering and Biotechnology, 2022
As a new cell-free therapy, exosomes have provided new ideas for the treatment of various diseases. Human induced pluripotent stem cells (hiPSCs) cannot be used in clinical trials because of tumorigenicity, but the exosomes derived from hiPSCs may ...
Zhewei Gu, Zhiyu Yin, Pengbo Song, Ying Wu, Ying He, Maoshu Zhu, Zhengxin Wu, Sicheng Zhao, Hongri Huang, Huihuang Wang, Cailing Tong, Zhongquan Qi   +11 more
doaj   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Amin R, Andrea Venerando, Angela Sepe, Anil Mehta, Anna Bossi, Anna Zolin, Antonella Tosco, Boyle MP BS, Carlo A Leone, Daniela De Stefano, Donaldson S., Fabiola De Gregorio, Fischer H, Gianni Bona, Gibson LE, Giuseppe De Rosa, Guido Kroemer, Illek B, Jayaraman S, Kerem B, Kerem Eithan HMO, Laura Salvadori, Legssyer R, Lorenzo A Pinna, Luigi Maiuri, Lukacs G, Maria C Maiuri, Massimo Pettoello-Mantovani, Masvidal L, Pharmaceuticals Cylene, Pharmaceuticals Cylene, Rosa Grassia, Speranza Esposito, Standardization of Spirometry, Stefano Guido, Stern M, Valeria R Villella, Valeria Raia, van Doorninck JH, Villella VR   +39 more
core   +4 more sources

A Randomized, Double-Blinded, Placebo-Controlled, Cross Over Study Evaluating the Efficacy and Safety of Timolol Ophthalmic Solution as an Acute Treatment of Migraine [PDF]

, 2020
Introduction. Daily oral beta-adrenoreceptor antagonist has been shown to be effective in preventing migraine headaches. Timolol 0.5% ophthalmic solution is a non-selective beta-adrenoreceptor antago- nist, where the primary use is for glaucoma.
Aggarwal, Dipika, Barohn, Richard J., Bittel, Brennen, Dubinsky, Richard, Ford, Deetra, Gronseth, Gary, Hairston, Vernita, Heim, Andrew J., Herbelin, Laura, Landazuri, Patrick, Sachen, Fred   +10 more
core   +2 more sources

Improved Efficiency of Pomegranate Seed Oil Administrated Nasally

Pharmaceutics, 2022
Pomegranate seed oil (PSO) is currently administrated orally as a food supplement for improving memory. However, the efficiency of the oral dosage forms for such purposes is low, mainly due to the blood brain barrier impeding a good delivery to brain. In this work, we designed and characterized a PSO phospholipid oily gel for nasal administration.
Hiba Natsheh, Elka Touitou
openaire   +3 more sources

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules.

Nanomedicine, 2019
Aim: To determine whether a p38 MAPK inhibitor incorporated into nanoemulsion-based chitosan nanocapsules can reduce the activity of this kinase in the brain through their nasal administration in mice.
Álvaro Casadomé-Perales, L. Matteis, M. Alleva, Cristina Infantes-Rodríguez, Irene Palomares-Pérez, T. Saito, T. Saido, J. Esteban, A. Nebreda, J. M. de la Fuente, C. Dotti   +10 more
semanticscholar   +1 more source

Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]

, 2012
Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed, Shivangi Jaiswal, Shruti Mishra, Sweta Kumari   +3 more
core   +2 more sources

Nasal administration of gonadotropin releasing hormone (GnRH) elicits sperm production in Fowler’s toads (Anaxyrus fowleri)

BMC Zoology, 2019
BackgroundDeclining amphibian populations around the world necessitate the establishment of captive assurance colonies as a hedge against extinction.
A. Julien, A. Kouba, David Kabelik, J. Feugang, S. Willard, C. Kouba   +5 more
semanticscholar   +1 more source