Results 51 to 60 of about 2,438,339 (329)

Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure [PDF]

, 2017
Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood.
Hurley, Joyce Harts, Johnson, Philip Lee, Kunkler, Phillip Edward, Oxford, Gerry Stephen, Zhang, LuJuan   +4 more
core   +1 more source

Influence of Immune Status on the Airborne Colonization of Piglets with Methicillin-Resistant Staphylococcus aureus (MRSA) Clonal Complex (CC) 398 [PDF]

, 2020
Colonized vertebrates including humans and pigs are to date the main reservoirs of livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA). Currently, the mechanisms underlying colonization of pigs are not fully understood.
Ebner, Friederike, Friese, Anika, Hartmann, Susanne, Merle, Roswitha, Roesler, Uwe, Rosen, Kerstin, Schmidt, Stefanie   +6 more
core   +1 more source

Treatment of the bone marrow stromal stem cell supernatant by nasal administration—a new approach to EAE therapy

Stem cell research & therapeutics, 2019
Multiple sclerosis (MS) is one of the most common autoimmune diseases of the central nervous system (CNS). CNS has its own unique structural and functional features, while the lack of precision regulatory element with high specificity as therapeutic ...
Xi Wang, Wantong Zhai, Jiahui Zhu, Wei Zhao, Xiaoyi Zou, Siying Qu, Shenyue Wang, Zhongze He, Zhaoying Li, Lingyang Wang, Bo Sun, Hulun Li   +11 more
semanticscholar   +1 more source

Ex vivo propofol permeation across nasal mucosa: A proof-of-concept study for outpatient light sedation via nasal route

ADMET and DMPK
Background and Purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injection.
Michele Domenico Spampinato, Anna Costanzini, Roberto De Giorgio, Angelina Passaro, Nicola Realdon, Fabrizio Bortolotti, Sabrina Banella, Gaia Colombo   +7 more
doaj   +1 more source

Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice

OncoTarget, 2018
Cognitive impairments are a common side effect of chemotherapy that often persists long after treatment completion. There are no FDA-approved interventions to treat these cognitive deficits also called ‘chemobrain’.
G. Chiu, N. Boukelmoune, Angie C A Chiang, Bo Peng, Vikram Rao, C. Kingsley, Ho-Ling Liu, A. Kavelaars, S. Kesler, C. Heijnen   +9 more
semanticscholar   +1 more source

Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration

Pharmaceutics, 2021
We have recently reported Catalytides (Catalytic peptides) JAL-TA9 (YKGSGFRMI) and ANA-TA9 (SKGQAYRMI), which are the first Catalytides found to cleave Aβ42. Although the Catalytides must be delivered to the brain parenchyma to treat Alzheimer’s disease,
Yusuke Hatakawa, Akiko Tanaka, Tomoyuki Furubayashi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sakane   +6 more
doaj   +1 more source

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing [PDF]

, 2007
Airway infection by the Gram-positive pathogen Streptococcus pneumoniae (Sp) leads to recruitment of neutrophils but limited bacterial killing by these cells.
Clarke, Thomas B., Dowson, Christopher G., Lysenko, Elena S., Ratner, Adam J., Roper, David I., Shchepetov, Mikhail, Weiser, Jeffrey N.   +6 more
core   +3 more sources

Nasal decongestants in monotherapy for the common cold [PDF]

, 2016
Background : Many treatments for the common cold exist and are sold over-the-counter. Nevertheless, evidence on the effectiveness and safety of nasal decongestants is limited.
De Sutter, An, Deckx, Laura, Guo, Linda, Mir, Nabiel A, van Driel, Marie   +4 more
core   +2 more sources

Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis

Pharmaceutics, 2019
Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream.
R. Pearson, T. Masud, E. Blackshaw, A. Naylor, M. Hinchcliffe, K. Jeffery, F. Jordan, Anjumn Shabir-Ahmed, Gareth King, A. Lewis, L. Illum, A. Perkins   +11 more
semanticscholar   +1 more source

Recent Advances in Nose-to-Brain Gene Delivery for Central Nervous System Disorders

Pharmaceutics
The nasal route represents a promising non-invasive technique for the direct delivery of nucleic acids to the central nervous system (CNS) disorders, effectively bypassing the blood–brain barrier.
Flávia Nathiely Silveira Fachel, Angélica Salatino-Oliveira, Willian da Silva Carniel, Rafaela Zimmermann, Ursula Matte, Helder Ferreira Teixeira, Guilherme Baldo, Roselena Silvestri Schuh   +7 more
doaj   +1 more source