Results 21 to 30 of about 7,581 (224)

New approach to curb the transmission of leprosy

Hansenologia Internationalis, 1989
The effect of local treatment of nose of lepromatous type of patients with different formulations of rifampicin nasal  rops/sprays was investigated in a large number of patients.
M.C. PRABHAKAR, A.V.N. APPA RAO, D.R. KRISHNA, T.V. RAMANAKAR, P.G. RAO, K. NARSIMHA REDDY   +5 more
doaj   +1 more source

Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.

PLoS ONE, 2013
ObjectivesChronic rhinosinusitis (CRS) is a common chronic disease of the upper airways and has considerable impact on quality of life. Topical delivery of drugs to the paranasal sinuses is challenging, therefore the rate of surgery is high.
Winfried Möller, Uwe Schuschnig, Gülnaz Celik, Wolfgang Münzing, Peter Bartenstein, Karl Häussinger, Wolfgang G Kreyling, Martin Knoch, Martin Canis, Sven Becker   +9 more
doaj   +1 more source

A Supine Position and Dual-Dose Applications Enhance Spray Dosing to the Posterior Nose: Paving the Way for Mucosal Immunization

Pharmaceutics, 2023
Delivering vaccines to the posterior nose has been proposed to induce mucosal immunization. However, conventional nasal devices often fail to deliver sufficient doses to the posterior nose.
Amr Seifelnasr, Mohamed Talaat, Pranav Ramaswamy, Xiuhua April Si, Jinxiang Xi   +4 more
doaj   +1 more source

Efficiency of Oral Steroids and Steroidal Nasal Spray in Treatment of Chronic Rhinosinusitis: A Comparative Study

Journal of Pharmacy and Bioallied Sciences
Objective: To assess how well steroidal nasal sprays and oral steroids work for treating CRS. Methods: Two hundred patients with CRS were included in a randomized controlled experiment.
Asma Ahmed, Rajunaik Ajmeera, Mahavir Satishchand Bagrecha, Ganaraj Shetty, D. Mallika, Priyanka Sharma, Raj Kumar Tiwari   +6 more
doaj   +1 more source

Evaluation of rheological and mucoadhesive properties of selected nasal spray preparations with mometasone furoate

Pediatria i Medycyna Rodzinna, 2017
Intranasal preparations with mometasone furoate are recognised to be highly efficient and safe in both adults and children. Commercially available nasal sprays are characterised by thixotropic and mucoadhesive properties – factors ensuring effortless ...
Emilia Szymańska, Katarzyna Winnicka
doaj   +1 more source

Colds, flu and coughing: A review of over-the-counter nasal therapies in general practice

South African Family Practice, 2013
Nasal congestion due to the common cold occurs because of dilation of the blood vessels, leading to swelling of the nasal mucosal epithelium. This narrows nasal passages, which are further blocked by increased mucus production. Nasal sprays and drops are
J. van Schoor
doaj   +1 more source

Nasal Septal Perforation Due to Desmopressin Nasal Spray Use

Ear, Nose & Throat Journal, 2023
Perforations of the nasal septum have many etiologies and occasionally result from intranasal medicated spray use. This case report describes a perforation related to the use of desmopressin nasal spray, which has not been previously reported in the ...
Daniela A. Brake MD, Grant S. Hamilton MD, Stephen F. Bansberg MD   +2 more
doaj   +1 more source

A Fentanyl‐Responsive Microneedle Patch for Harm Reduction

Advanced Science, EarlyView.
A fentanyl‐responsive microneedle patch is developed as a self‐regulating overdose intervention that releases naloxone upon detecting fentanyl. The system employs aptamer‐functionalized nanoparticles embedded in a swellable polymer matrix to enable rapid, on‐demand drug delivery through the skin.
Penghui Zhao, Zerui Zhou, Tyler Wolter, Huanqing Niu, Yuanzhi Bian, Chixia Tian, Chun Xu, Chenming Zhang, Juhong Chen, Matthew W. Buczynski, Wujin Sun   +10 more
wiley   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery

Advanced Science, EarlyView.
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie, Jiahe Liu, Xiangyu Zhao, Siying Yang, Han Sun, Bingqian Jia, Xiaohong Ren, Xintao Chen, Lixin Sun, Li Wu, Caifen Wang, Jiwen Zhang   +11 more
wiley   +1 more source

Premedication Methods in Nasal Endoscopy: A Prospective, Randomized, Double-Blind Study [PDF]

Clinical and Experimental Otorhinolaryngology, 2017
Objectives To identify the optimal pharmacological method of preparing patients for nasal endoscopy. Methods Twenty healthy volunteers were enrolled in this prospective, randomized, double-blind study.
Mehmet İlhan Şahin, Kerem Kökoğlu, Şafak Güleç, İbrahim Ketenci, Yaşar Ünlü   +4 more
doaj   +1 more source