Results 41 to 50 of about 7,581 (224)
Development of a nalmefene formulation suitable for a community‐use auto‐injector
British Journal of Clinical Pharmacology, EarlyView.Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Objectives This paper aims to describe the treatment patterns of contemporary systemic menopausal hormone therapy (MHT) in Denmark. Study design This study is a nationwide drug utilization study including an open cohort of all Danish women aged >40 years between 2000–2024.
Hannah K. Wood‐Kurland +7 more
wiley +1 more source
Septal Release: A Targeted Surgical Strategy for Recurrent Epistaxis
Eye &ENT Research, EarlyView.ABSTRACT Background Recurrent epistaxis is a common pediatric condition that is typically managed with conservative therapies, but a subset of patients require surgical intervention after treatment failure. We seek to describe the efficacy of septal release for refractory pediatric epistaxis patients. Objective To compare outcomes of septal release for
Alexandra Welschmeyer +6 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective We assessed the timing, dosing, and effectiveness of diazepam nasal spray in a large dataset of seizures treated in the out‐of‐hospital setting, using as reference the International League Against Epilepsy criteria for tonic–clonic status epilepticus (SE) and its treatment.
John M. Stern +10 more
wiley +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
JMIR Medical Education, 2020 BackgroundAllergic rhinitis is a common disorder affecting both children and adults. Recommended treatment consists of intranasal corticosteroid spray administration, but only few patients administer the nasal spray in the correct technical manner.
Peters-Geven, Marije M +4 more
doaj +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Streptococcus equi subspecies zooepidemicus is a highly diverse opportunistic pathogen of horses, associated with respiratory disease and endometritis. Objectives To characterise S. zooepidemicus isolates recovered from young ponies during a natural episode of respiratory disease, and to determine if vaccination with Strangvac®, a ...
Romain Paillot +8 more
wiley +1 more source
Pneumocoele sinus: Computed tomographic findings and surgical approach in a 2‐year‐old Cob filly
Equine Veterinary Journal, EarlyView.Abstract Background Pneumosinus dilatans and pneumocoele sinus describe abnormal hyperpneumatisation of paranasal sinuses, with the latter being accompanied by thinning of bony walls. Although recognised in human and equine medicine, to the authors' knowledge, this condition's computed tomography (CT) findings and successful surgical approach in horses
Sarah L. Thompson +3 more
wiley +1 more source