Results 91 to 100 of about 846,625 (333)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Histone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior

Nature Communications
Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depressive disorder (MDD), stress-mediated ...
Amni Al-Kachak, Giuseppina Di Salvo, Sasha L. Fulton, Jennifer C Chan, Lorna A. Farrelly, Ashley E. Lepack, Ryan M. Bastle, Lingchun Kong, Flurin Cathomas, Emily L. Newman, Caroline Menard, Aarthi Ramakrishnan, Polina Safovich, Yang Lyu, Herbert E. Covington, Li Shen, Kelly Gleason, Carol A. Tamminga, Scott J. Russo, Ian Maze   +19 more
doaj   +1 more source

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy

Human Vaccines & Immunotherapeutics, 2020
The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor.
Anissa A. Widjaja, Sonia P. Chothani, Stuart A. Cook   +2 more
doaj   +1 more source

The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain

Scientific Reports, 2023
Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the CNS remains unknown.
Maciej J. Lazarczyk, Brett A. Eyford, Merina Varghese, Hitesh Arora, Lonna Munro, Tahia Warda, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Timothy Rumbell, Wilfred A. Jefferies, Dara L. Dickstein   +11 more
doaj   +1 more source

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

Science Translational Medicine, 2021
Increased Jagged1 in pericentral hepatocytes causes liver fibrosis in response to hepatocyte TLR4–NF-κB pathway activation in NASH. A ligand for Notch in NASH Notch activation is known to occur during the development of nonalcoholic steatohepatitis (NASH)
Junjie Yu, Changyu Zhu, Xiaobo Wang, KyeongJin Kim, Alberto Bartolomé, P. Dongiovanni, Katherine P. Yates, Luca Valenti, M. Carrer, T. Sadowski, L. Qiang, I. Tabas, J. Lavine, U. Pajvani   +13 more
semanticscholar   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Equilibria Under the Probabilistic Serial Rule [PDF]

, 2015
The probabilistic serial (PS) rule is a prominent randomized rule for assigning indivisible goods to agents. Although it is well known for its good fairness and welfare properties, it is not strategyproof.
Aziz, Haris, Gaspers, Serge, Mackenzie, Simon, Mattei, Nicholas, Narodytska, Nina, Walsh, Toby   +5 more
core  

A Hydraulic Approach to Equilibria of Resource Selection Games

, 2016
Drawing intuition from a (physical) hydraulic system, we present a novel framework, constructively showing the existence of a strong Nash equilibrium in resource selection games (i.e., asymmetric singleton congestion games) with nonatomic players, the ...
Gonczarowski, Yannai A., Tennenholtz, Moshe   +1 more
core   +1 more source