Results 1 to 10 of about 176,389 (357)

Dysregulated lipid metabolism links NAFLD to cardiovascular disease

Molecular Metabolism, 2020
Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD patients.
Audrey Deprince, Joel Haas, Bart Staels   +2 more
exaly   +2 more sources

NAFLD and cardiovascular diseases: a clinical review

Clinical Research in Cardiology, 2020
Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in Western countries and affects approximately 25% of the adult population. Since NAFLD is frequently associated with further metabolic comorbidities such as obesity, type
Sonja Lang, Hans-Michael Steffen, Philipp Kasper   +2 more
exaly   +2 more sources

Protective association of Klotho rs495392 gene polymorphism against hepatic steatosis in non-alcoholic fatty liver disease patients [PDF]

Clinical and Molecular Hepatology, 2022
Background/Aims Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic variation acts as important modifiers.
Wen-Yue Liu, Xiaofang Zhang, Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Rafael S. Rios, Kenneth I. Zheng, Hong-Lei Ma, Xiao-Dong Wang, Qiuwei Pan, Robert J. de Knegt, Luca Valenti, Mohsen Ghanbari, Ming-Hua Zheng   +13 more
doaj   +1 more source

The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review

Hepatology, 2023
Background and Aims: NAFLD is a leading cause of liver-related morbidity and mortality. We assessed the global and regional prevalence, incidence, and mortality of NAFLD using an in-depth meta-analytic approach.
Z. Younossi, P. Golabi, James M. Paik, Austin Henry, Catherine Van Dongen, L. Henry   +5 more
semanticscholar   +1 more source

Histological Characteristics of Non-alcoholic Steatohepatitis in NAFLD Patients With Low Degree of Hepatocyte Apoptosis

The Turkish Journal of Gastroenterology, 2021
Background: Caspase-cleaved K18 (cK18) may accurately reflect hepatocyte apoptosis in patients with non-alcoholic steatohepatitis (NASH). However, NASH can also exist within the normal range of cK18.
Hong-Lei Ma, Kenneth I. Zheng, Rafael S. Rios, Liang-Jie Tang, Gang Li, Pei-Wu Zhu, Xiao-Dong Wang, Yong-Ping Chen, Ming-Hua Zheng   +8 more
doaj   +1 more source

Imaging biomarkers of NAFLD, NASH, and fibrosis

Molecular Metabolism, 2021
Background: Non-alcoholic fatty liver disease (NAFLD) is a clinicopathologic entity that requires a liver biopsy assessment to diagnose the progressive form of NAFLD called non-alcoholic steatohepatitis (NASH).
Veeral Ajmera, Rohit Loomba
doaj   +1 more source

Characteristic gene expression in the liver monocyte-macrophage-DC system is associated with the progression of fibrosis in NASH

Frontiers in Immunology, 2023
BackgroundThe monocyte-macrophage-dendritic cell (DC) (MMD) system exerts crucial functions that may modulate fibrogenesis in nonalcoholic steatohepatitis (NASH).
Xiaoxiao Wang, Zilong Wang, Baiyi Liu, Rui Jin, Yuyun Song, Ran Fei, Xu Cong, Rui Huang, Xiaohe Li, Jia Yang, Lai Wei, Huiying Rao, Feng Liu   +12 more
doaj   +1 more source

Collagen co-localized with macrovesicular steatosis better differentiates fibrosis progression in non-alcoholic fatty liver disease mouse models

Frontiers in Medicine, 2023
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a global commonly occurring liver disease. However, its exact pathogenesis is not fully understood.
Xiao-Xiao Wang, Rui Jin, Xiao-He Li, Qiang Yang, Xiao Teng, Fang-Fang Liu, Nan Wu, Hui-Ying Rao, Feng Liu   +8 more
doaj   +1 more source

Factors associated with unrecognized cirrhosis in patients with hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology, 2023
Background/Aims Cirrhosis is the most important risk factor of hepatocellular carcinoma (HCC), and patients with cirrhosis are recommended to receive semiannual surveillance for early HCC detection.
Yi-Te Lee, Mohammad A. Karim, Hye Chung Kum, Sulki Park, Nicole E. Rich, Mazen Noureddin, Amit G. Singal, Ju Dong Yang   +7 more
doaj   +1 more source

Changing epidemiology, global trends and implications for outcomes of NAFLD.

Journal of Hepatology, 2023
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver disease globally, currently estimated to affect 38% of the global population. A minority of patients with NAFLD will progress to cirrhosis or hepatocellular carcinoma, but
Vincent Wai-Sun Wong, M. Ekstedt, Grace Lai-Hung Wong, Hannes Hagström   +3 more
semanticscholar   +1 more source