Results 1 to 10 of about 113,966 (168)

Effects of PPARα, PPARγ, and dual PPARα/γ agonists on liver tissue and biochemical markers in NAFLD-induced Wistar rats [PDF]

open access: yesResearch in Pharmaceutical Sciences
Background and purpose: Non-alcoholic fatty liver disease (NAFLD) is the most common liver-related metabolic disorder worldwide, affecting approximately 25% of the global population.
Elham Khoshbakht   +4 more
doaj   +2 more sources

تخمین جریان زیرسطحی دامنه‌های حوضه آبخیز با استفاده از مدل‌های ناش و SCS [PDF]

open access: yesمهندسی منابع آب, 2021
مقدمه: تخمین جریان زیرسطحی(SUF)  در بسیاری از حوضه­های آبریز با پوشش گیاهی مناسب و نفوذ پذیری خاک بالا حائز اهمیت است و نقش اساسی در تولید رواناب مستقیم حوضه دارد.
حسین فریبرزی   +2 more
doaj   +1 more source

Secret contracting and Nash-in-Nash bargaining

open access: yesSN Business & Economics, 2021
In take-it-or-leave-it vertical contracting, an equilibrium with passive beliefs may fail to exist. We argue that this problem can be alleviated by tackling the contracting stage of the game through a cooperative approach. The outcome of the take-it-or-leave-it game then coincides with the limit of the cooperative solution when the bargaining power of ...
Bacchiega, Emanuele, Bonroy, Olivier
openaire   +3 more sources

Obesity and binge alcohol intake are deadly combination to induce steatohepatitis: A model of high-fat diet and binge ethanol intake [PDF]

open access: yesClinical and Molecular Hepatology, 2020
Obesity and binge drinking often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. In this mini-review, we briefly summarize clinical evidence of the synergistical effect of obesity and heavy ...
Seonghwan Hwang, Tianyi Ren, Bin Gao
doaj   +1 more source

Pleiotropic effects of ipragliflozin

open access: yesКлинический разбор в общей медицине, 2023
Type 2 diabetes mellitus and its complications is a serious threat to the health and lives of the world's population. Among the causes of death in type 2 diabetes mellitus are both cardiovascular and non-vascular causes. Sodium-glucose cotransporter type
Nina A. Petunina   +5 more
doaj   +1 more source

Nash blocks [PDF]

open access: yesInternational Journal of Game Theory, 2021
AbstractA product set of pure strategies is a Nash block if it contains all best replies to the Nash equilibria of the game in which the players are restricted to the strategies in the block. This defines an intermediate block property, between curb (Basu and Weibull, Econ Lett 36(2):141–146, 10.1016/0165-1765(91)90179-O, http://www.sciencedirect.com ...
openaire   +2 more sources

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons

open access: yesNature Communications, 2023
Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves reconfiguration of gene regulatory circuits to establish regenerative gene programs. However, the underlying mechanisms remain unclear.
Dalia Halawani   +7 more
doaj   +1 more source

Scramblases as Regulators of Autophagy and Lipid Homeostasis: Implications for NAFLD

open access: yesAutophagy Reports, 2022
Equilibration of phospholipids between the two monolayers of the lipid bilayer of cellular membranes is mediated by scramblases acting as phospholipid shuttling proteins that are critical for cellular function, particularly during inter-organelle contact.
Allen Chen, Wen-Xing Ding, Hong-Min Ni
doaj   +1 more source

Effect of ipragliflozin on metabolic syndrome components and non-alcoholic fatty liver disease

open access: yesМедицинский совет, 2021
Sodium-glucose cotransporter-2 inhibitors are the new drugs for the treatment of type 2 diabetes mellitus. Its mechanism of action is to increase the excretion of glucose in the urine due to inhibition of reabsorption in the proximal renal tubules, which
N. A. Petunina   +2 more
doaj   +1 more source

Minian, an open-source miniscope analysis pipeline

open access: yeseLife, 2022
Miniature microscopes have gained considerable traction for in vivo calcium imaging in freely behaving animals. However, extracting calcium signals from raw videos is a computationally complex problem and remains a bottleneck for many researchers ...
Zhe Dong   +9 more
doaj   +1 more source

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