Results 1 to 10 of about 257,609 (309)

تخمین جریان زیرسطحی دامنه‌های حوضه آبخیز با استفاده از مدل‌های ناش و SCS [PDF]

open access: yesمهندسی منابع آب, 2021
مقدمه: تخمین جریان زیرسطحی(SUF)  در بسیاری از حوضه­های آبریز با پوشش گیاهی مناسب و نفوذ پذیری خاک بالا حائز اهمیت است و نقش اساسی در تولید رواناب مستقیم حوضه دارد.
حسین فریبرزی   +2 more
doaj   +1 more source

Obesity and binge alcohol intake are deadly combination to induce steatohepatitis: A model of high-fat diet and binge ethanol intake [PDF]

open access: yesClinical and Molecular Hepatology, 2020
Obesity and binge drinking often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. In this mini-review, we briefly summarize clinical evidence of the synergistical effect of obesity and heavy ...
Seonghwan Hwang, Tianyi Ren, Bin Gao
doaj   +1 more source

Pleiotropic effects of ipragliflozin

open access: yesКлинический разбор в общей медицине, 2023
Type 2 diabetes mellitus and its complications is a serious threat to the health and lives of the world's population. Among the causes of death in type 2 diabetes mellitus are both cardiovascular and non-vascular causes. Sodium-glucose cotransporter type
Nina A. Petunina   +5 more
doaj   +1 more source

Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons

open access: yesNature Communications, 2023
Axon regeneration of dorsal root ganglia (DRG) neurons after peripheral axotomy involves reconfiguration of gene regulatory circuits to establish regenerative gene programs. However, the underlying mechanisms remain unclear.
Dalia Halawani   +7 more
doaj   +1 more source

Scramblases as Regulators of Autophagy and Lipid Homeostasis: Implications for NAFLD

open access: yesAutophagy Reports, 2022
Equilibration of phospholipids between the two monolayers of the lipid bilayer of cellular membranes is mediated by scramblases acting as phospholipid shuttling proteins that are critical for cellular function, particularly during inter-organelle contact.
Allen Chen, Wen-Xing Ding, Hong-Min Ni
doaj   +1 more source

Effect of ipragliflozin on metabolic syndrome components and non-alcoholic fatty liver disease

open access: yesМедицинский совет, 2021
Sodium-glucose cotransporter-2 inhibitors are the new drugs for the treatment of type 2 diabetes mellitus. Its mechanism of action is to increase the excretion of glucose in the urine due to inhibition of reabsorption in the proximal renal tubules, which
N. A. Petunina   +2 more
doaj   +1 more source

Minian, an open-source miniscope analysis pipeline

open access: yeseLife, 2022
Miniature microscopes have gained considerable traction for in vivo calcium imaging in freely behaving animals. However, extracting calcium signals from raw videos is a computationally complex problem and remains a bottleneck for many researchers ...
Zhe Dong   +9 more
doaj   +1 more source

Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes: Evaluation of Hepatic Fibrosis and Steatosis Using Fibroscan

open access: yesDiagnostics, 2020
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of non-alcoholic fatty liver disease (NAFLD) and might eventually progress to advanced fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Tran Thi Khanh Tuong   +5 more
doaj   +1 more source

Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions

open access: yesNature Communications, 2021
New instrumental learning occurs through an unexpected delivery of a rewarding stimulus or the withdrawal of a punishing stimulus. The authors show that D1 receptor-expressing medium spiny neurons (MSNs) in the anterior dorsolateral striatum encode newly
Alexander C. W. Smith   +7 more
doaj   +1 more source

Developing nondestructive techniques for managing conflicts between fisheries and double‐crested cormorant colonies

open access: yesWildlife Society Bulletin, 2015
Double‐crested cormorants (Phalacrocorax auritus) have been identified as the source of significant mortality to juvenile salmonids (Oncorhynchus spp.) in the Columbia River Basin.
Yasuko Suzuki   +4 more
doaj   +1 more source

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