Results 41 to 50 of about 257,609 (309)

Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats

Nature Communications
Neurobiological alterations seen in addiction amplify during abstinence and compromise relapse prevention. Cocaine use disorder (CUD) exemplifies this phenomenon in which reward regions such as nucleus accumbens (NAc) undergo withdrawal-associated ...
Freddyson J. Martínez-Rivera, Leanne M. Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh, Solange Tofani, Rita Futamura, Caleb J. Browne, Philipp Mews, Li Shen, Eric J. Nestler   +10 more
doaj   +1 more source

Universality of Nash Equilibria [PDF]

Mathematics of Operations Research, 2003
Every real algebraic variety is isomorphic to the set of totally mixed Nash equilibria of some three-person game, and also to the set of totally mixed Nash equilibria of an N-person game in which each player has two pure strategies. From the Nash-Tognoli Theorem it follows that every compact differentiable manifold can be encoded as the set of totally
openaire   +2 more sources

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Fatty liver disease is not associated with increased mortality in the elderly: A prospective cohort study

Hepatology, EarlyView., 2022
Graphical abstract summarizing the study design, main results and key findings Abstract Background and Aims Fatty liver disease (FLD) has been associated with excess mortality. Screening for hepatic steatosis (HS) in patients with metabolic dysfunction is therefore recommended by several guidelines, despite a paucity of evidence on the clinical ...
Laurens A. van Kleef, Milan J. Sonneveld, Maryam Kavousi, M. Arfan Ikram, Robert A. de Man, Robert J. de Knegt   +5 more
wiley   +1 more source

Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles

Nature Communications
Learned associations between the rewarding effects of drugs and the context in which they are experienced are critical for context-induced relapse. While context re-exposure triggers the recall of such drug-related associative memories it is unclear ...
Marine Salery, Arthur Godino, Yu Qing Xu, John F. Fullard, Romain Durand-de Cuttoli, Alexa R. LaBanca, Leanne M. Holt, Scott J. Russo, Panos Roussos, Eric J. Nestler   +9 more
doaj   +1 more source

Equilibrium in Nash’s mind [PDF]

SSRN Electronic Journal, 2020
Donald Capps suggested the hypothesis that “the Nash equilibrium is descriptive of the normal brain, whereas the game theory formulated by John van Neumann, which Nash’s theory challenges, is descriptive of the schizophrenic brain”. The paper offers arguments in its favor. They are from psychiatry, game theory, set theory, philosophy and theology.
openaire   +4 more sources

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Nature Communications, 2019
Early life stress alters behavioural response to adult stress in female mice. Here authors transcriptionally profile three brain regions involved in reward (ventral tegmental area, nucleus accumbens, and prefrontal cortex) in both male and female adult ...
Catherine Jensen Peña, Milo Smith, Aarthi Ramakrishnan, Hannah M. Cates, Rosemary C. Bagot, Hope G. Kronman, Bhakti Patel, Austin B. Chang, Immanuel Purushothaman, Joel Dudley, Hirofumi Morishita, Li Shen, Eric J. Nestler   +12 more
doaj   +1 more source

Nash epidemics

CoRR
Faced with a dangerous epidemic humans will spontaneously social distance to reduce their risk of infection at a socio-economic cost. Compartmentalised epidemic models have been extended to include this endogenous decision making: Individuals choose their behaviour to optimise a utility function, self-consistently giving rise to population behaviour ...
Simon K. Schnyder, John J. Molina, Ryoichi Yamamoto, Matthew S. Turner   +3 more
openaire   +2 more sources