Results 51 to 60 of about 722,784 (293)

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats

Nature Communications
Neurobiological alterations seen in addiction amplify during abstinence and compromise relapse prevention. Cocaine use disorder (CUD) exemplifies this phenomenon in which reward regions such as nucleus accumbens (NAc) undergo withdrawal-associated ...
Freddyson J. Martínez-Rivera, Leanne M. Holt, Angélica Minier-Toribio, Molly Estill, Szu-Ying Yeh, Solange Tofani, Rita Futamura, Caleb J. Browne, Philipp Mews, Li Shen, Eric J. Nestler   +10 more
doaj   +1 more source

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Nature Communications, 2019
Early life stress alters behavioural response to adult stress in female mice. Here authors transcriptionally profile three brain regions involved in reward (ventral tegmental area, nucleus accumbens, and prefrontal cortex) in both male and female adult ...
Catherine Jensen Peña, Milo Smith, Aarthi Ramakrishnan, Hannah M. Cates, Rosemary C. Bagot, Hope G. Kronman, Bhakti Patel, Austin B. Chang, Immanuel Purushothaman, Joel Dudley, Hirofumi Morishita, Li Shen, Eric J. Nestler   +12 more
doaj   +1 more source

New species of Parmeliaceae (lichenized Ascomycotina) from South America [PDF]

, 1995
The species Flavoparmelia quichuaensis Elix & T. H. Nash, Hypotrachyna divaricatica Elix & T. H. Nash, Hypotrachyna goiasii Elix & Nash, Hypotrachyna hypoalectorialica Elix & T. H. Nash and Relicina xanthoparmeliformis Elix & T. H.
Elix, John A., Nash III, Thomas H.
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles

Nature Communications
Learned associations between the rewarding effects of drugs and the context in which they are experienced are critical for context-induced relapse. While context re-exposure triggers the recall of such drug-related associative memories it is unclear ...
Marine Salery, Arthur Godino, Yu Qing Xu, John F. Fullard, Romain Durand-de Cuttoli, Alexa R. LaBanca, Leanne M. Holt, Scott J. Russo, Panos Roussos, Eric J. Nestler   +9 more
doaj   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson’s disease

Stem Cell Research & Therapy, 2021
The derivation of human embryonic stem cells followed by the discovery of induced pluripotent stem cells and leaps in genome editing approaches have continuously fueled enthusiasm for the development of new models of neurodegenerative diseases such as ...
Elena Coccia, Tim Ahfeldt
doaj   +1 more source