Results 11 to 20 of about 147,468 (308)

Immunotherapy for NAFLD and NAFLD-related hepatocellular carcinoma

Frontiers in Endocrinology, 2023
The progression of non-alcoholic fatty liver disease (NAFLD), the most common liver disease, leads to non-alcoholic steatohepatitis and hepatocellular carcinoma. Despite the increasing incidence and prevalence of NAFLD, its therapeutic and preventive strategies to lower the disease burden is limited.
Seogsong Jeong, Seogsong Jeong, Woo-Young Shin, Yun Hwan Oh   +3 more
openaire   +3 more sources

New targets for NAFLD [PDF]

JHEP Reports, 2021
Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our understanding of its aetiology and pathophysiology.
Parlati, Lucia, Régnier, Marion, Guillou, Hervé, Postic, Catherine   +3 more
openaire   +3 more sources

Current management of NAFLD [PDF]

Medicine and Pharmacy Reports, 2016
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. It affects about 1 billion individuals worldwide. While people with simple steatosis have no higher risk of death than the general population, people with non-alcoholic steatohepatitis are at increased risk of death compared to general ...
MUNTEANU, MIHAI ALEXANDRU, NAGY, GEORGIANA ANCA, MIRCEA, PETRU ADRIAN   +2 more
openaire   +2 more sources

NAFLD/MAFLD: New Evidence

International Journal of Molecular Sciences, 2023
The aim of the second edition of our Special Issue, entitled “Nonalcoholic Fatty Liver Disease/Metabolic Associated Fatty Liver Disease: New Insights 2 [...]
Alessandro Mantovani, Andrea Dalbeni
openaire   +2 more sources

Nonalcoholic fatty liver disease in Brazil. Clinical and histological profile

Annals of Hepatology, 2011
Background. The epidemiology and clinical characteristics of nonalcoholic fatty liver disease (NAFLD) in South America are not well known. Brazil is a largest country in this part of the world and the present study aimed to contribute with this ...
Helma P. Cotrim, Edison R. Parise, Claudia P.M.S. Oliveira, Natalhie Leite, Ana Martinelli, Joào Galizzi, Rita de Càssia Silva, Ângelo Mattos, Leila Pereira, Waldir Amorim, Claúdia Ivantes, Francisco Souza, Marcelo Costa, Lizomar Maia, Màrio Pessoa, Frederico Oliveira   +15 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. [PDF]

, 2014
ObjectiveNonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality.
Behling, Cynthia, Donithan, Michele, Hallinan, Erin K, Newton, Kimberly P, Nonalcoholic Steatohepatitis Clinical Research Network, Schwimmer, Jeffrey B, Tonascia, James, Xanthakos, Stavra A, Zepeda, Anne   +8 more
core   +6 more sources

Evaluation of polygenic determinants of non-alcoholic fatty liver disease (NAFLD) by a candidate genes resequencing strategy [PDF]

, 2018
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 genes ...
Angelico F, Angeloni A, Arca M, Bailetti D, Baratta F, Belardinilli F, Ceci F, D'Erasmo L, De Masi B, Del Ben M, Di Costanzo A, Giannini G, Girelli G, Montali A, Pastori D, Polimeni L, Sponziello M   +16 more
core   +1 more source

Natural History of NAFLD [PDF]

Journal of Clinical Medicine, 2021
The epidemiology and the current burden of chronic liver disease are changing globally, with non-alcoholic fatty liver disease (NAFLD) becoming the most frequent cause of liver disease in close relationship with the global epidemics of obesity, type 2 diabetes and metabolic syndrome.
Pais, Raluca, Maurel, Thomas
openaire   +3 more sources