Results 171 to 180 of about 10,823 (257)
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu +5 more
wiley +1 more source
Analysis of ~1000 adults shows cytokine gene variants are more strongly associated with hematological and metabolic traits than fitness classification. IL6 and TNF‐α variants link to iron status and aerobic fitness, with exploratory multi‐locus effects involving IL15. ABSTRACT Genetic variation in cytokine genes may influence cytokine‐related signaling,
Kinga Humińska‐Lisowska +6 more
wiley +1 more source
The role of mitochondrial dynamics in metabolic dysfunction-associated steatotic liver disease. [PDF]
Yang N, Hao Y.
europepmc +1 more source
Pharmaceutical Pricing and R&D as a Global Public Good
ABSTRACT This paper examines the international variation in the prices of branded pharmaceuticals. We consider short‐run profits, or quasi‐rents, as representing each country's contribution toward the global public good of therapeutic information embodied in new pharmaceuticals.
H. E. Frech III +3 more
wiley +1 more source
A stochastic framework to assess the optimal allocation of limited vaccine doses in foot-and-mouth disease outbreaks using game theory. [PDF]
Moreno-Torres KI +6 more
europepmc +1 more source
Attribution of Future Water Stress in a Two‐Way Coupled Socioeconomic–Hydrological Framework
We dynamically couple the Global Change Analysis Model (GCAM) with the integrated land simulator (ILS) through exchanges of land use and surface‐water availability, enabling consistent representation of water balance and human water use. Century‐scale simulations (2020–2100) were conducted under four SSP scenarios at 0.5° resolution for ILS and 32 ...
Tetsuya Fukuda +5 more
wiley +1 more source
HyAR-PPO: Hybrid Action Representation Learning for Incentive-Driven Task Offloading in Vehicular Edge Computing. [PDF]
Wang W, Li M, Wu H.
europepmc +1 more source
Macrophage: Biological Functions, Diseases, and Therapeutic Targets
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun +4 more
wiley +1 more source
Model predictive game control for personalized and targeted interactive assistance. [PDF]
Hafs A +5 more
europepmc +1 more source
ABSTRACT This study develops a dynamic game model of intimate relationship conflicts that incorporates emotion regulation mechanisms, translating cognitive reappraisal and expressive suppression into strategic parameters. The model simulates the dynamic evolution of defensive strategies and intervention paths, capturing the continuous interplay between
Yiwen Liu
wiley +1 more source

