Results 171 to 180 of about 10,823 (257)

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

open access: yesAdvanced Science, Volume 13, Issue 44, 7 August 2026.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu   +5 more
wiley   +1 more source

Cytokine Gene Variants Are Associated With Aerobic Fitness‐Related, Hematological, and Metabolic Traits in Healthy Adults

open access: yesComprehensive Physiology, Volume 16, Issue 4, August 2026.
Analysis of ~1000 adults shows cytokine gene variants are more strongly associated with hematological and metabolic traits than fitness classification. IL6 and TNF‐α variants link to iron status and aerobic fitness, with exploratory multi‐locus effects involving IL15. ABSTRACT Genetic variation in cytokine genes may influence cytokine‐related signaling,
Kinga Humińska‐Lisowska   +6 more
wiley   +1 more source

Pharmaceutical Pricing and R&D as a Global Public Good

open access: yesHealth Economics, Volume 35, Issue 8, Page 1158-1174, August 2026.
ABSTRACT This paper examines the international variation in the prices of branded pharmaceuticals. We consider short‐run profits, or quasi‐rents, as representing each country's contribution toward the global public good of therapeutic information embodied in new pharmaceuticals.
H. E. Frech III   +3 more
wiley   +1 more source

A stochastic framework to assess the optimal allocation of limited vaccine doses in foot-and-mouth disease outbreaks using game theory. [PDF]

open access: yesFront Vet Sci
Moreno-Torres KI   +6 more
europepmc   +1 more source

Attribution of Future Water Stress in a Two‐Way Coupled Socioeconomic–Hydrological Framework

open access: yesHydrological Processes, Volume 40, Issue 8, August 2026.
We dynamically couple the Global Change Analysis Model (GCAM) with the integrated land simulator (ILS) through exchanges of land use and surface‐water availability, enabling consistent representation of water balance and human water use. Century‐scale simulations (2020–2100) were conducted under four SSP scenarios at 0.5° resolution for ILS and 32 ...
Tetsuya Fukuda   +5 more
wiley   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun   +4 more
wiley   +1 more source

Model predictive game control for personalized and targeted interactive assistance. [PDF]

open access: yesCommun Eng
Hafs A   +5 more
europepmc   +1 more source

Defensive Strategies and Handling Paths in Intimate Relationship Conflicts: A Dynamic Game Model From the Perspective of Emotional Regulation

open access: yesPsyCh Journal, Volume 15, Issue 4, August 2026.
ABSTRACT This study develops a dynamic game model of intimate relationship conflicts that incorporates emotion regulation mechanisms, translating cognitive reappraisal and expressive suppression into strategic parameters. The model simulates the dynamic evolution of defensive strategies and intervention paths, capturing the continuous interplay between
Yiwen Liu
wiley   +1 more source

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