Results 121 to 130 of about 48,656 (208)

Beneficence‐Based Obligations and Ethics Consultation in Assisted Dying

Bioethics, EarlyView.
ABSTRACT In ethical debates on assisted dying, the principle of respect for autonomy is usually invoked to justify respecting requests for assisted dying. However, there are not only autonomy‐based obligations, but also obligations arising from the principle of beneficence towards persons requesting assisted dying.
Georg Marckmann, Anna Hirsch
wiley   +1 more source

A11 Peptide Enhances Radiosensitivity by Degrading EphA2 in Nasopharyngeal Carcinoma

Cancer Science, EarlyView.
In EphA2‐high‐expressing nasopharyngeal carcinoma cells, radiation triggers RSK‐dependent phosphorylation of EphA2 at Ser897, which in turn activates AKT and promote radioresistance. The A11 peptide breaks this signaling cascade by degrading EphA2 and blocking its S897 phosphorylation, thereby markedly enhancing radiosensitivity.
Ming Zhang, Zhi‐Qiang Xiao, Wei Huang, Shan‐Shan Lu, Hong Yi, Juan Feng   +5 more
wiley   +1 more source

ZNF844 Suppresses Invasion and Metastasis in Nasopharyngeal Carcinoma by Inhibiting the PI3K‐AKT Signaling Pathway

Cancer Science, EarlyView.
ZNF844 functions as a tumor suppressor in NPC by inhibiting invasion and metastasis through regulation of the PI3K‐AKT signaling pathway. It may serve as a promising therapeutic target and prognostic biomarker for NPC. ABSTRACT Epigenetic regulation plays a crucial role in the development of nasopharyngeal carcinoma (NPC).
Jinping Xu, Cancan Chen, Bin Zhang, Shufang Liao, Yunyan Mo, Rongjun Zhang, Xiangyun Kong, Wei Jiang   +7 more
wiley   +1 more source

Oral Health—Head and Neck Cancers: Addressing Confounding Through Negative Control and Quantitative Bias Analyses

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives While there are plausible biological explanations for the association between oral health and head and neck cancers (HNC), existing studies have yielded conflicting results. A key concern is that these associations are influenced by mediators, unmeasured risk factors, and biases. To address this, a negative control exposure was used
P. K. Elango, B. Nicolau, N. Farsi, A. V. Grant, M. C. Rousseau, S. Madathil   +5 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Clinicopathological Analysis and Survival Outcomes of Radiation‐Induced Oral Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Radiotherapy‐induced malignancies are well‐documented, but the clinicopathological profile and prognostic factors of radiation‐induced oral squamous cell carcinoma (R‐OSCC) remain unclear. Methods The present review was conducted in accordance with the PRISMA guidelines and has been registered in the PROSPERO (registration number ...
Anne Evelyn Oliveira Moura, Carla Isabelly Rodrigues‐Fernandes, Ana Gabriela Costa Normando, Danielle Machado Farias, Márcio Ajudarte Lopes, Pablo Agustin Vargas, Alan Roger Santos‐Silva, Fábio de Abreu Alves, Luiz Paulo Kowalski, Danyel Elias da Cruz Perez   +9 more
wiley   +1 more source

Prognostic Significance of the Pretreatment Neutrophil‐to‐Lymphocyte Ratio and Tumor‐Associated Neutrophils in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta‐Analysis

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Objectives The prognostic significance of the neutrophil‐to‐lymphocyte ratio (NLR) and tumor‐associated neutrophils (TANs) in head and neck squamous cell carcinoma (HNSCC) remains a subject of considerable research interest. This systematic review and meta‐analysis aimed to evaluate the relationship between pretreatment NLR and TANs and ...
Ahana Kapuge Dona Varuni Yashodha Ratnayake, Aini Hyytiäinen, Georgia Vasiliki Gkountana, Meri Torri, Ahmed Al‐Samadi   +4 more
wiley   +1 more source

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non‐Smokers and Non‐Drinkers

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Introduction While the prevalence of microsatellite instability (MSI) is low in the whole head and neck squamous cell carcinoma (HNSCC) population, it has been suggested to be more prominent in tumors of non‐smokers. Therefore, the goal of this study was to determine the presence of MSI in a cohort of well‐defined HNSCC of non‐smokers and non ...
F. J. Mulder, T. F. B. Gielgens, E. J. de Ruiter, R. de Bree, M. F. C. M. van den Hout, B. Kremer, S. M. Willems, E. J. M. Speel   +7 more
wiley   +1 more source

PERBEDAAN SKOR GERIATRIC DEPRESSION SCALE PADA PASIEN USIA LANJUT DENGAN KANKER KEPALA DAN LEHER YANG BELUM DAN SEDANG MENJALANI RADIOTERAPI [PDF]

, 2016
Background. There has been a constant rise in the elderly population number throughout the world, more so in the developing countries. This growth is paralleled with rapid increase in disease prevalence, head and neck cancer being one of them.
Saktini, Fanti, Sekarnegari, Gendis, Wardani, Natalia Dewi   +2 more
core  

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source