Results 211 to 220 of about 129,288 (306)

AARS1‐mediated AKR1B10 lactylation stabilizes an aerobic glycolysis‐positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
AKR1B10 confers lenvatinib resistance by enhancing aerobic glycolysis in HCC cells. AKR1B10 undergoes AARS1‐mediated lactylation at K173, stabilizing it by antagonizing ubiquitin‐proteasomal degradation. AKR1B10 promotes LDHA Y10 phosphorylation, boosting lactate production, which drives H3K18la‐mediated transcriptional upregulation of LDHA, creating a
Zijian Liu   +7 more
wiley   +1 more source

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan   +6 more
wiley   +1 more source

Analysis of the application of 3D-printed personalized positioning fixation in nasopharyngeal carcinoma radiotherapy. [PDF]

open access: yesJ Appl Clin Med Phys
Ding Z   +10 more
europepmc   +1 more source

Targeting neutrophil‐driven immunosuppression: A strategy to overcome immune checkpoint inhibitor resistance

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TANs drive ICI resistance via antitumour immune remodelling, angiogenesis promotion, and elevation of tumour mutation burden Neutrophil biomarkers (e.g., NLR, TAN abundance) show strong predictive value for ICI response and prognosis. Targeting TAN recruitment, polarization, function and NETosis represents a promising strategy to overcome ICI ...
Ying Ning   +7 more
wiley   +1 more source

OC-0535: A prospective multi-center study of plasma EBV DNA monitoring in nasopharyngeal carcinoma

open access: bronze, 2015
Jian Lin   +5 more
openalex   +1 more source

The suffering experiences of patients with nasopharyngeal carcinoma in China: a qualitative study. [PDF]

open access: yesBMJ Open
Song S   +8 more
europepmc   +1 more source

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