Results 91 to 100 of about 386,285 (319)

Exploring the long‐term effects of COVID‐19 in patients with epilepsy: A multicenter Italian observational study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Coronavirus disease‐19 (COVID‐19), caused by SARS‐CoV‐2, has led to a global pandemic since December 2019. People with epilepsy (PwE) face higher risks of severe COVID‐19 outcomes and may be more vulnerable to long‐term neurological and psychiatric effects. Methods This multicenter, retrospective cohort study reviewed medical records
Fedele Dono   +8 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

open access: yesExploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang   +20 more
wiley   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

open access: yesExploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu   +5 more
wiley   +1 more source

Multidimensional Prognostic Index as a Predictor of Mortality in Head and Neck Cancer Patients: A Cohort Study

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Head and neck cancer (HNC) significantly impacts older adults, with mortality influenced by multiple factors. The Multidimensional Prognostic Index (MPI), derived from comprehensive geriatric assessment (CGA), may improve risk stratification and clinical decision making. Methods An observational cohort study was conducted at Erasmus
Ajay T. Bakas   +5 more
wiley   +1 more source

Deep Learning Pipeline for Automated Assessment of Distances Between Tonsillar Tumors and the Internal Carotid Artery

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Evaluating the minimum distance (dTICA) between the internal carotid artery (ICA) and tonsillar tumors (TT) on imaging is essential for preoperative planning; we propose a tool to automatically extract dTICA. Methods CT scans of 96 patients with TT were selected from the cancer imaging archive.
Aseem Jain   +4 more
wiley   +1 more source

Quad Shot—A Tertiary Hospital Experience With a Palliative Radiotherapy Regimen for Head and Neck Cancer

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Head and neck cancer patients often present with locally advanced disease. For some patients, palliative treatment schedules focused on symptom control are often preferred. Perhaps the most widely used of these is the so‐called Quad Shot (QS) regimen.
Eirini Nikolaidou   +5 more
wiley   +1 more source

Geographic and Socioeconomic Landscape of Veterans With Head and Neck Cancer

open access: yesHead &Neck, EarlyView.
ABSTRACT Background US Veterans experience higher rates and worse outcomes for head and neck squamous cell carcinoma (HNSCC) compared to civilians. Geographic and socioeconomic barriers remain unclear. Methods This retrospective descriptive study analyzed VA data nationwide (2012–2022), identifying Veterans with HNSCC using ICD codes. Subsites included
Kristen L. Zayan   +8 more
wiley   +1 more source

Central nervous system changes complicating the use of radiotherapy for the treatment of a nasopharyngeal neoplasm in a diabetic patient [PDF]

open access: bronze, 1979
Bruce A. Smith   +3 more
openalex   +1 more source

The Management of Head and Neck Lymphoedema: A 2025 Systematic Review

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Head and Neck Lymphoedema (HNL) is debilitating to many domains of patients' structure and function, yet it is the most poorly researched form of lymphoedema. This is due to the variety of signs and symptoms experienced by HNL patients, and this makes it difficult to formulate standardized staging classifications and treatment ...
Rohan Rajaram   +4 more
wiley   +1 more source

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