Results 201 to 210 of about 372,044 (296)

AARS1‐mediated AKR1B10 lactylation stabilizes an aerobic glycolysis‐positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
AKR1B10 confers lenvatinib resistance by enhancing aerobic glycolysis in HCC cells. AKR1B10 undergoes AARS1‐mediated lactylation at K173, stabilizing it by antagonizing ubiquitin‐proteasomal degradation. AKR1B10 promotes LDHA Y10 phosphorylation, boosting lactate production, which drives H3K18la‐mediated transcriptional upregulation of LDHA, creating a
Zijian Liu, Jingsheng Yuan, Shitong Su, Jiaqi Han, Ni Zeng, Yuhan Ma, Nianyong Chen, Tao Lv   +7 more
wiley   +1 more source

Tertiary lymphoid structures: Defining immune subtypes and enabling precision immunotherapy in nasopharyngeal carcinoma

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Fan Liu, Lei Xiong, Xia Yu, Mingfang Ji
wiley   +1 more source

Pan‐cancer multi‐omics reveals DCAF7 as an immune‐modulating prognostic driver and Wnt/β‐catenin activator in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DCAF7 is up‐regulated in various tumours and correlates with poor prognosis, particularly in LIHC. High DCAF7 expression is linked to CD4+ T cell infiltration, up‐regulation of immune checkpoint genes and increased tumour mutational burden, suggesting a role in tumour immune escape.
Ruina Luan, Hanbin Lin, Xin Zhao, Jianpeng Li, Maohe Chen, Shiping Luo, Xinjian Lin   +6 more
wiley   +1 more source

Natural Dietary Compounds Targeting NF‐κB Signaling in Cancer: Implications for Nutrition‐Based Prevention and Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dysregulation of the nuclear factor kappa B (NF‐κB) signaling pathway is closely associated with inflammation‐driven carcinogenesis, tumor progression and resistance to conventional therapies. Sustained NF‐κB activation enhances malignant cell survival, proliferation and immune evasion by promoting proinflammatory and antiapoptotic gene ...
Maria Sharif, Iqra Mutiullah, Kafila Kausar, Rashid Khan, Muhammad Irfan, Solomon Habtemariam, Khushbukhat Khan, Cristina Quispe, William C. Cho, Javad Sharifi‐Rad, Daniela Calina   +10 more
wiley   +1 more source

Metagenomic analysis of DNA viruses from posttransplant lymphoproliferative disorders [PDF]

, 2019
Chen, Chun-Cheng, Dharnidharka, Vikas R, Goss, Charles W, Gu, Hongjie, O\u27Gorman, Harry, Parameswaran, Priyanka, Ruzinova, Marianna B, Storch, Gregory A, Wylie, Kristine   +8 more
core   +2 more sources

Artificial Intelligence‐Based In Silico Evaluation of the Pharmacological Potential and In Vitro Anti‐Malignancy Effect in the Human Glioblastoma Cell Line of the Hydrate of the Coumarin Compound Meranzin Originating From the Edible Macroalga (Bangia fuscopurpurea)

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
In U87 cells, meranzin hydrate showed cytotoxicity (MIC = 50 μM) and anti‐invasion activity (IC50 = 33.12 μM) but had no inhibitory effect on colony formation. It also suppressed the cancer stem cell property of sphere formation (IC50 = 21.43 μM). In silico analysis indicated that meranzin hydrate may downregulate the protein expression of ALDH1A1 and ...
Shi‐Ying Huang, Yi‐Chen Chang, Charles Chien‐Chih Chiu, Chang‐Wei Hsieh, Chien‐Wei Feng, Zhi‐Cheng Chen, Nan‐Fu Chen, Yung‐Kuo Lee, Tian‐Huei Chu, Cheng‐Chieh Fang, Nan‐Chieh Huang   +10 more
wiley   +1 more source

Nasopharyngeal Endoscopic Resection Extended to the Internal Carotid Artery (Type 4): Technical Notes, Indications, and Outcomes

Head &Neck, Volume 48, Issue 1, Page 148-159, January 2026.
ABSTRACT Background Endoscopic surgical approaches for nasopharyngeal malignancies, including recurrent nasopharyngeal carcinoma (rNPC) and nasopharyngeal salivary gland tumors (NSGT), have seen significant development over the last decades. Our groups have expanded the classification of nasopharyngeal endoscopic resections (NER) from type 1 to 3 to ...
Francesco Boaria, Alessandro Vinciguerra, Stefano Taboni, Martina Conti, Paola Costantino, Vittorio Rampinelli, Marco Valentini, Francesca Gennarini, Benjamin Verillaud, Elisabetta Zanoletti, Davide Mattavelli, Alberto Schreiber, Mario Turri‐Zanoni, Alberto Daniele Arosio, Piergiorgio Gaudioso, Paolo Battaglia, Maurizio Bignami, Paolo Castelnuovo, Philippe Herman, Piero Nicolai, Marco Ferrari   +20 more
wiley   +1 more source

Safety and Efficacy Findings From a Phase Ib/II Study of ASP‐1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Head &Neck, Volume 48, Issue 1, Page 160-174, January 2026.
ABSTRACT Background ASP‐1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing. Methods This phase Ib/II open‐label study evaluated ASP‐1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD‐L1 ...
David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne M. Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater   +17 more
wiley   +1 more source

Effects of intraduodenally applied bile salts on pancreatic secretion [PDF]

, 1993
Lehnert, Peter, Riepl, Rudolf L.
core   +1 more source

Management of Retropharyngeal Lymph Node Metastases in Thyroid Cancer

Head &Neck, Volume 48, Issue 1, Page 237-245, January 2026.
ABSTRACT Background Retropharyngeal lymph node (RPLN) metastases in thyroid cancer are rare, with optimal management underreported. Methods Retrospective study of consecutive thyroid cancer patients with RPLN metastases treated at MD Anderson Cancer Center between 2000 and 2024.
Isabelle Fournier, Ashwini Venkata Bandi, Sarah Hamidi, Priyanka Iyer, Naifa L. Busaidy, Maria E. Cabanillas, Ramona Dadu, Mimi I. Hu, Steven G. Waguespack, Ugur Nur Basmaci, Michelle D. Williams, Mena Mansour, Maria Gule Monroe, Neil D. Gross, Ryan P. Goepfert, Nancy D. Perrier, Victoria Banuchi, Jennifer R. Wang, Anastasios Maniakas, Mark E. Zafereo   +19 more
wiley   +1 more source