Results 91 to 100 of about 133,869 (230)

Epigenetic Activation of ANGPTL4 Drives EBV‐Negative Gastric Cancer via Neutrophil Recruitment and NET Release via Stabilizing ANXA5

Advanced Science, EarlyView.
ANGPTL4 exhibits distinct promoter methylation patterns and expression profiles in EBV‐positive versus EBV‐negative gastric cancer. Secreted C‐terminal ANGPTL4 (cANGPTL4) acts as the dominant functional isoform driving GC proliferation, EMT, and neutrophil infiltration. cANGPTL4 promotes neutrophil recruitment via NF‐κB/CXCL8 axis.
Dandan Li, Xinqi Li, Xiangyin Luo, Jiayi Wang, Yiwei Zha, Zeng Zhou, Yanyan Chen, Qi Wang, Lingyun Xia, Weidong Leng, Shanshan Qin   +10 more
wiley   +1 more source

Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens

Emerging Infectious Diseases, 2021
Among symptomatic outpatients, subgenomic RNA of severe acute respiratory syndrome coronavirus 2 in nasal midturbinate swab specimens was concordant with antigen detection but remained detectable in 13 (82.1%) of 16 nasopharyngeal swab specimens from ...
Katherine Immergluck, Mark D. Gonzalez, Jennifer K. Frediani, Joshua M. Levy, Janet Figueroa, Anna Wood, Beverly B. Rogers, Jared O’Neal, Roger Elias-Marcellin, Allie Suessmith, Julie Sullivan, Raymond F. Schinazi, Ahmed Babiker, Anne Piantadosi, Miriam B. Vos, Greg S. Martin, Wilbur A. Lam, Jesse J. Waggoner   +17 more
doaj   +1 more source

Evaluation of SARS-CoV-2 isolation in cell culture from nasal/nasopharyngeal swabs or saliva specimens of patients with COVID-19

Scientific Reports, 2023
It has been revealed that SARS-CoV-2 can be efficiently isolated from clinical specimens such as nasal/nasopharyngeal swabs or saliva in cultured cells.
Shunsuke Yazawa, Emiko Yamazaki, Yumiko Saga, Masae Itamochi, Noriko Inasaki, Takahisa Shimada, Kazunori Oishi, Hideki Tani   +7 more
doaj   +1 more source

Differences in SARS‐CoV‐2 Antigen Persistence in Individuals With Systemic Autoimmune Rheumatic Diseases Compared to the General Population: A RECOVER‐Adult Cohort Study

Arthritis &Rheumatology, EarlyView.
Objective Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post–acute COVID‐19 outcomes, though whether individuals with SARDs have longer persistence of viral antigens after COVID‐19 has not been studied.
Naomi J. Patel, Zoe Swank, Jiaqi Wang, Xiaosong Wang, Lauren A. O'Keeffe, Madison Negron, Liya S. Getachew, Louise L. Hansen, Grace Qian, Alene A. Saavedra, Kevin T. Mueller, Natalie A. Davis, Kathleen M. M. Vanni, Sandria Savage, Julie S. Lam, Zachary S. Wallace, David R. Walt, Jeffrey A. Sparks, on behalf of RECOVER‐Adult   +18 more
wiley   +1 more source

Safety management of nasopharyngeal specimen collection from suspected cases of coronavirus disease 2019

International Journal of Nursing Sciences, 2020
This article introduces safety management strategies of nasopharyngeal specimen collection from suspected cases of coronavirus disease 2019 in a tertiary designated hospital.
Yan Qian, Tieying Zeng, Hui Wang, Min Xu, Junhua Chen, Na Hu, Daiqi Chen, Yu Liu   +7 more
doaj   +1 more source

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci, Carlotta Bidoli, Marco Gerdol, Charisse Winston, Robert A. Rissman, Giuliana Decorti, Antonella Fabretto, Andrea Taddio, Gabriele Stocco, Erik Roman‐Pognuz, Marianna Lucafò   +10 more
wiley   +1 more source

Comparison of results of direct RT-LAMP assay with RT-LAMP assays obtained from 145 clinical nasopharyngeal swab specimens.

, 2013
aA total of 145 clinical nasopharyngeal swab specimens detected by RT-LAMP included 124 EV71 positive and 21 EV71 negative samples.
Yi Zhang (9093), Kai Nie (293664), Le Luo (277248), Shun-xiang Qi (293666), Qi Li (67548), Yong Zhang (5893), Hongwei Shen (293670), Jin Li (119007), Xue-jun Ma (293672), Yun Xie (293668), Meng-jie Yang (293669)   +10 more
core   +1 more source

Antiviral Activity and Safety of Molnupiravir in Healthy Participants Inoculated With Influenza Virus: A Phase 2a, Randomized, Human Challenge Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Influenza viruses cause substantial global morbidity and mortality. Molnupiravir, an orally administered prodrug of β‐D‐N4‐hydroxycytidine, has broad activity against RNA viruses, including influenza. A phase 2a, randomized, two‐part human challenge trial in healthy adults (NCT05818124) was conducted to evaluate molnupiravir for influenza infection. In
Jesse Nussbaum, Alex J. Mann, Laura E. Liao, Tian Zhao, Melissa Bevan, Gillian Gillespie, Vanessa Levine Weissler, Brian M. Maas, Diane Longo, Andrew Catchpole, David W. Hilbert, Carisa De Anda   +11 more
wiley   +1 more source

Reliability of a single-nostril nasopharyngeal swab for diagnosing SARS-CoV-2 infection

, 2023
In this study we compared the viral load measured after collecting a single nasopharyngeal swab from each nostril to that obtained from the standard recommend double-nostril NOS. The study population consisted of 21 consecutive healthcare workers (median
Giuseppe Lippi, Gian Luca Salvagno, Simone De Nitto, Henry, Brandon M, De Nitto, Simone, Brandon M. Henry, Laura Pighi, Pighi, Laura, Salvagno, Gian Luca, Lippi, Giuseppe   +9 more
core   +1 more source

The prevalence of Streptococcus equi subsp. equi carriers in the Netherlands

Equine Veterinary Journal, EarlyView.
Abstract Background Streptococcus equi subspecies equi (S. equi) carriers are thought to be important drivers for strangles outbreaks. Limited data are available on the prevalence of carriers in European horse husbandry settings. Objectives To estimate the prevalence of S.
R. M. A. C. Houben, E. M. Broens, M. J. Broekhuizen‐Stins, M. M. Sloet van Oldruitenborgh‐Oosterbaan, C. van Maanen, J. A. P. Heesterbeek   +5 more
wiley   +1 more source